======= TSC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSC2
  * **<color #00a2e8>Official Name</color>**: TSC complex subunit 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7249|7249]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49815|P49815]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191092|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  Mutations in this gene lead to tuberous sclerosis complex. Its gene product is believed to be a tumor suppressor and is able to stimulate specific GTPases. The protein associates with hamartin in a cytosolic complex, possibly acting as a chaperone for hamartin. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF3384|
|Tuberin|
|Rap GAP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|TSC1-TSC2 complex|
|negative regulation of mitophagy|
|negative regulation of autophagy of mitochondrion|
|anoikis|
|negative regulation of phosphatidylinositol 3-kinase signaling|
|insulin-like growth factor receptor signaling pathway|
|regulation of mitophagy|
|small GTPase binding|
|negative regulation of macroautophagy|
|negative regulation of insulin receptor signaling pathway|
|negative regulation of cellular response to insulin stimulus|
|protein kinase B signaling|
|Hsp90 protein binding|
|regulation of autophagy of mitochondrion|
|negative regulation of protein kinase B signaling|
|positive chemotaxis|
|phosphatase binding|
|negative regulation of TOR signaling|
|negative regulation of mitochondrion organization|
|regulation of insulin receptor signaling pathway|
|positive regulation of macroautophagy|
|regulation of cellular response to insulin stimulus|
|negative regulation of autophagy|
|neural tube closure|
|tube closure|
|protein import into nucleus|
|primary neural tube formation|
|regulation of TOR signaling|
|neural tube formation|
|import into nucleus|
|regulation of phosphatidylinositol 3-kinase signaling|
|positive regulation of autophagy|
|embryonic epithelial tube formation|
|epithelial tube formation|
|protein import|
|morphogenesis of embryonic epithelium|
|tube formation|
|neural tube development|
|protein localization to nucleus|
|regulation of macroautophagy|
|regulation of mitochondrion organization|
|regulation of endocytosis|
|negative regulation of Wnt signaling pathway|
|regulation of protein kinase B signaling|
|negative regulation of protein kinase activity|
|negative regulation of kinase activity|
|lysosome|
|postsynaptic density|
|negative regulation of cellular catabolic process|
|nucleocytoplasmic transport|
|nuclear transport|
|negative regulation of transferase activity|
|GTPase activator activity|
|epithelial tube morphogenesis|
|negative regulation of catabolic process|
|regulation of autophagy|
|regulation of small GTPase mediated signal transduction|
|regulation of Wnt signaling pathway|
|positive regulation of cellular catabolic process|
|negative regulation of organelle organization|
|negative regulation of protein phosphorylation|
|positive regulation of GTPase activity|
|positive regulation of catabolic process|
|morphogenesis of an epithelium|
|establishment of protein localization to organelle|
|negative regulation of phosphorylation|
|regulation of GTPase activity|
|negative regulation of intracellular signal transduction|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|heart development|
|chemotaxis|
|regulation of vesicle-mediated transport|
|taxis|
|endocytosis|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|tissue morphogenesis|
|embryonic morphogenesis|
|negative regulation of protein modification process|
|chordate embryonic development|
|embryo development ending in birth or egg hatching|
|tube morphogenesis|
|negative regulation of cell population proliferation|
|import into cell|
|perinuclear region of cytoplasm|
|viral process|
|negative regulation of cellular component organization|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|positive regulation of hydrolase activity|
|symbiotic process|
|negative regulation of catalytic activity|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|tube development|
|circulatory system development|
|regulation of kinase activity|
|protein homodimerization activity|
|anatomical structure formation involved in morphogenesis|
|apoptotic process|
|embryo development|
|regulation of transferase activity|
|Golgi apparatus|
|regulation of catabolic process|
|intracellular protein transport|
|negative regulation of cellular protein metabolic process|
|programmed cell death|
|cell death|
|negative regulation of protein metabolic process|
|epithelium development|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of signal transduction|
|regulation of hydrolase activity|
|regulation of organelle organization|
|locomotion|
|negative regulation of cell communication|
|negative regulation of signaling|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|intracellular signal transduction|
|tissue development|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
|vesicle-mediated transport|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-3.57|
|[[:results:exp360|Genistein 15μM R07 exp360]]|-3.31|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-3.26|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.7|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.62|
|[[:results:exp24|Nocodazole 0.2μM R00 exp24]]|-2.58|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.56|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.55|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|-2.51|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|-2.48|
|[[:results:exp274|Citral 50μM R06 exp274]]|-2.47|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-2.47|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.45|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|-2.41|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|-2.4|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|-2.39|
|[[:results:exp8|Brefeldin A 0.02μM R00 exp8]]|-2.36|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|-2.34|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|-2.26|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|-2.26|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-2.26|
|[[:results:exp111|R-DABN 8μM R03 exp111]]|-2.25|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|-2.25|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-2.24|
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.23|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|-2.23|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|-2.21|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.17|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|-2.15|
|[[:results:exp80|RO-3307 4.7μM R02 exp80]]|-2.11|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.11|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.1|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.04|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|-2.03|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-2.03|
|[[:results:exp224|CB-839 10μM R05 exp224]]|-2.02|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-2|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.99|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|-1.98|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|-1.95|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.95|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|-1.94|
|[[:results:exp100|NFN1 1μM R03 exp100]]|-1.93|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.92|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.88|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-1.88|
|[[:results:exp538|ZLN024 50μM R08 exp538]]|-1.87|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-1.86|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-1.86|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-1.86|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-1.85|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.83|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-1.82|
|[[:results:exp148|SB202190 10μM R03 exp148]]|-1.81|
|[[:results:exp81|Selumetinib 20μM R02 exp81]]|-1.8|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-1.79|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.79|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|-1.78|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|-1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|-1.76|
|[[:results:exp291|LLY-284 2.6μM R06 exp291]]|-1.75|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.75|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-1.74|
|[[:results:exp462|Cadmium 60μM R08 exp462]]|-1.72|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-1.72|
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.71|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-1.7|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|1.72|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|1.8|
|[[:results:exp463|Caffeine 2600μM R08 exp463]]|1.87|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.87|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|1.91|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|1.94|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.03|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.1|
|[[:results:exp414|Tozasertib 0.1μM R07 exp414]]|2.1|
|[[:results:exp418|Tunicamycin 0.04μM R07 exp418]]|2.1|
|[[:results:exp391|Pomalidomide 20μM R07 exp391]]|2.12|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|2.22|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|2.52|
|[[:results:exp189|Temozolomide 200μM R04 exp189]]|2.52|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|2.67|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|2.95|
|[[:results:exp423|Zebularine 20μM R07 exp423]]|3.1|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|3.16|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|3.5|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|3.62|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|3.7|
|[[:results:exp419|Tunicamycin 0.04 to 0.075μM  on day4 R07 exp419]]|3.73|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|3.81|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|4.03|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|4.47|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|4.68|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|7.07|
|[[:results:exp504|MK2206 4μM R08 exp504]]|8.44|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tsc1|TSC1]]|0.826|
|[[:human genes:n:nprl2|NPRL2]]|0.664|
|[[:human genes:n:nprl3|NPRL3]]|0.653|
|[[:human genes:d:depdc5|DEPDC5]]|0.628|
|[[:human genes:s:szt2|SZT2]]|0.562|
|[[:human genes:k:kptn|KPTN]]|0.556|
|[[:human genes:i:itfg2|ITFG2]]|0.555|
|[[:human genes:c:c12orf66|C12orf66]]|0.543|
|[[:human genes:t:tbc1d7|TBC1D7]]|0.493|
|[[:human genes:f:fam122a|FAM122A]]|0.491|
|[[:human genes:s:sesn2|SESN2]]|0.463|
|[[:human genes:c:cdk8|CDK8]]|0.438|
|[[:human genes:n:naa50|NAA50]]|0.436|
|[[:human genes:g:gsk3b|GSK3B]]|0.434|
|[[:human genes:e:eif4b|EIF4B]]|0.425|
|[[:human genes:c:ctnnbl1|CTNNBL1]]|0.414|
|[[:human genes:c:cnot2|CNOT2]]|0.414|
|[[:human genes:g:gsk3a|GSK3A]]|0.412|
|[[:human genes:n:nans|NANS]]|0.41|
|[[:human genes:y:ypel5|YPEL5]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 18/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|3/28|
|bone|0/26|
|breast|1/33|
|central nervous system|1/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|2/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 2132
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.39 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSC2 Expression in NALM6 Cells: 6.39'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>