======= TSG101 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSG101
  * **<color #00a2e8>Official Name</color>**: tumor susceptibility 101
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7251|7251]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q99816|Q99816]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSG101&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSG101|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601387|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene belongs to a group of apparently inactive homologs of ubiquitin-conjugating enzymes. The gene product contains a coiled-coil domain that interacts with stathmin, a cytosolic phosphoprotein implicated in tumorigenesis. The protein may play a role in cell growth and differentiation and act as a negative growth regulator. In vitro steady-state expression of this tumor susceptibility gene appears to be important for maintenance of genomic stability and cell cycle regulation. Mutations and alternative splicing in this gene occur in high frequency in breast cancer and suggest that defects occur during breast cancer tumorigenesis and/or progression. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Binds to ubiquitinated cargo proteins and is required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies (MVBs). Mediates the association between the ESCRT-0 and ESCRT-I complex. Required for completion of cytokinesis; the function requires CEP55. May be involved in cell growth and differentiation. Acts as a negative growth regulator. Involved in the budding of many viruses through an interaction with viral proteins that contain a late-budding motif P-[ST]-A-P. This interaction is essential for viral particle budding of numerous retroviruses. Required for the exosomal release of SDCBP, CD63 and syndecan (PubMed:22660413). It may also play a role in the extracellular release of microvesicles that differ from the exosomes (PubMed:22315426). {ECO:0000269|PubMed:11916981, ECO:0000269|PubMed:17556548, ECO:0000269|PubMed:17853893, ECO:0000269|PubMed:21070952, ECO:0000269|PubMed:21757351, ECO:0000269|PubMed:22315426, ECO:0000269|PubMed:22660413}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Vps23 core|
|UEV|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|regulation of ubiquitin-dependent endocytosis|
|positive regulation of ubiquitin-dependent endocytosis|
|positive regulation of viral budding via host ESCRT complex|
|regulation of viral budding via host ESCRT complex|
|exosomal secretion|
|extracellular exosome biogenesis|
|regulation of extracellular exosome assembly|
|extracellular vesicle biogenesis|
|ESCRT I complex|
|virion binding|
|negative regulation of epidermal growth factor-activated receptor activity|
|positive regulation of viral release from host cell|
|positive regulation of exosomal secretion|
|regulation of exosomal secretion|
|viral budding via host ESCRT complex|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|viral budding|
|regulation of epidermal growth factor-activated receptor activity|
|Flemming body|
|negative regulation of protein tyrosine kinase activity|
|extracellular transport|
|multivesicular body assembly|
|regulation of viral release from host cell|
|multivesicular body organization|
|multivesicular body|
|autophagosome maturation|
|virion assembly|
|negative regulation of epidermal growth factor receptor signaling pathway|
|negative regulation of peptidyl-tyrosine phosphorylation|
|negative regulation of ERBB signaling pathway|
|endosome to lysosome transport|
|intracellular transport of virus|
|host cell|
|transport of virus|
|negative regulation of signaling receptor activity|
|calcium-dependent protein binding|
|positive regulation of viral life cycle|
|protein monoubiquitination|
|nuclear receptor transcription coactivator activity|
|multi-organism localization|
|multi-organism transport|
|endosome organization|
|ubiquitin binding|
|regulation of epidermal growth factor receptor signaling pathway|
|positive regulation of exocytosis|
|regulation of protein tyrosine kinase activity|
|regulation of ERBB signaling pathway|
|positive regulation of endocytosis|
|lysosomal transport|
|positive regulation of viral process|
|late endosome membrane|
|late endosome|
|vacuolar transport|
|regulation of viral life cycle|
|cell cycle arrest|
|early endosome membrane|
|microtubule organizing center|
|macroautophagy|
|regulation of signaling receptor activity|
|viral life cycle|
|regulation of viral process|
|regulation of endocytosis|
|endosome membrane|
|regulation of organelle assembly|
|regulation of symbiosis, encompassing mutualism through parasitism|
|regulation of exocytosis|
|negative regulation of protein kinase activity|
|endosomal transport|
|protein-containing complex disassembly|
|transcription corepressor activity|
|negative regulation of kinase activity|
|regulation of peptidyl-tyrosine phosphorylation|
|early endosome|
|autophagy|
|process utilizing autophagic mechanism|
|protein-containing complex binding|
|endosome|
|keratinocyte differentiation|
|negative regulation of transferase activity|
|ubiquitin protein ligase binding|
|vesicle organization|
|epidermal cell differentiation|
|positive regulation of cellular protein localization|
|regulation of MAP kinase activity|
|skin development|
|cellular component disassembly|
|positive regulation of secretion by cell|
|negative regulation of protein phosphorylation|
|epidermis development|
|regulation of cell growth|
|endomembrane system organization|
|positive regulation of protein transport|
|positive regulation of secretion|
|negative regulation of phosphorylation|
|positive regulation of establishment of protein localization|
|cell division|
|positive regulation of multi-organism process|
|regulation of protein serine/threonine kinase activity|
|positive regulation of cellular component biogenesis|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|regulation of vesicle-mediated transport|
|positive regulation of locomotion|
|negative regulation of phosphate metabolic process|
|negative regulation of phosphorus metabolic process|
|negative regulation of cell cycle|
|proteolysis involved in cellular protein catabolic process|
|negative regulation of protein modification process|
|cellular protein catabolic process|
|regulation of growth|
|negative regulation of cell population proliferation|
|epithelial cell differentiation|
|protein catabolic process|
|protein ubiquitination|
|viral process|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of MAPK cascade|
|organelle assembly|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|symbiotic process|
|negative regulation of catalytic activity|
|exocytosis|
|regulation of protein kinase activity|
|regulation of secretion|
|interspecies interaction between organisms|
|nucleolus|
|regulation of kinase activity|
|protein homodimerization activity|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|regulation of transferase activity|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|cell cycle process|
|secretion by cell|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|export from cell|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|epithelium development|
|secretion|
|negative regulation of molecular function|
|regulation of cell cycle|
|negative regulation of transcription, DNA-templated|
|positive regulation of cellular component organization|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|regulation of organelle organization|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|negative regulation of biosynthetic process|
|amide transport|
|regulation of phosphorylation|
|establishment of protein localization|
|regulation of cell population proliferation|
|negative regulation of response to stimulus|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|tissue development|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp19|Etoposide 1μM R00 exp19]]|-2.5|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|-2.1|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|-2.03|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|-1.98|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|-1.92|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|-1.87|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-1.83|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|-1.77|
|[[:results:exp476|Dihydrosphingosine 8μM R08 exp476]]|1.71|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb4|PSMB4]]|0.565|
|[[:human genes:c:chd4|CHD4]]|0.553|
|[[:human genes:t:tceb3c|TCEB3C]]|0.52|
|[[:human genes:c:copg1|COPG1]]|0.516|
|[[:human genes:c:ccna2|CCNA2]]|0.511|
|[[:human genes:n:npipb5|NPIPB5]]|0.506|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.503|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.493|
|[[:human genes:d:dhx38|DHX38]]|0.492|
|[[:human genes:k:krt78|KRT78]]|0.492|
|[[:human genes:k:kctd17|KCTD17]]|0.492|
|[[:human genes:r:rrp7a|RRP7A]]|0.49|
|[[:human genes:u:utp3|UTP3]]|0.488|
|[[:human genes:z:znf830|ZNF830]]|0.488|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.485|
|[[:human genes:l:lrr1|LRR1]]|0.483|
|[[:human genes:p:pan3|PAN3]]|0.477|
|[[:human genes:t:tpx2|TPX2]]|0.474|
|[[:human genes:s:supt5h|SUPT5H]]|0.474|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.473|
|[[:human genes:r:rps2|RPS2]]|0.47|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.47|
|[[:human genes:m:mt1e|MT1E]]|0.467|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.465|
|[[:human genes:s:skiv2l2|SKIV2L2]]|0.464|
|[[:human genes:p:paf1|PAF1]]|0.464|
|[[:human genes:n:nupl1|NUPL1]]|0.463|
|[[:human genes:c:cbwd3|CBWD3]]|0.462|
|[[:human genes:n:napa|NAPA]]|0.461|
|[[:human genes:b:brd2|BRD2]]|0.461|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.461|
|[[:human genes:s:slc4a1|SLC4A1]]|0.461|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.46|
|[[:human genes:a:ankle2|ANKLE2]]|0.459|
|[[:human genes:c:ctage4|CTAGE4]]|0.458|
|[[:human genes:p:psmb2|PSMB2]]|0.458|
|[[:human genes:d:ddx56|DDX56]]|0.457|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.457|
|[[:human genes:c:cbwd5|CBWD5]]|0.457|
|[[:human genes:x:xylt2|XYLT2]]|0.457|
|[[:human genes:d:dtl|DTL]]|0.456|
|[[:human genes:p:psmc5|PSMC5]]|0.455|
|[[:human genes:t:timeless|TIMELESS]]|0.454|
|[[:human genes:s:sf3a2|SF3A2]]|0.454|
|[[:human genes:v:vps28|VPS28]]|0.45|
|[[:human genes:p:pole|POLE]]|0.449|
|[[:human genes:g:gid4|GID4]]|0.445|
|[[:human genes:p:psmd3|PSMD3]]|0.445|
|[[:human genes:p:psma6|PSMA6]]|0.445|
|[[:human genes:o:orc6|ORC6]]|0.443|
|[[:human genes:s:sf3a3|SF3A3]]|0.442|
|[[:human genes:c:cactin|CACTIN]]|0.441|
|[[:human genes:u:upf1|UPF1]]|0.441|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.441|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.441|
|[[:human genes:p:psmd8|PSMD8]]|0.44|
|[[:human genes:r:ranbp2|RANBP2]]|0.44|
|[[:human genes:p:prpf19|PRPF19]]|0.44|
|[[:human genes:p:psmd11|PSMD11]]|0.439|
|[[:human genes:c:copa|COPA]]|0.438|
|[[:human genes:a:atp6v1b2|ATP6V1B2]]|0.437|
|[[:human genes:c:chaf1a|CHAF1A]]|0.437|
|[[:human genes:s:sec13|SEC13]]|0.437|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.436|
|[[:human genes:c:cdca3|CDCA3]]|0.436|
|[[:human genes:e:exosc6|EXOSC6]]|0.435|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.435|
|[[:human genes:o:orc1|ORC1]]|0.435|
|[[:human genes:n:nup160|NUP160]]|0.434|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.434|
|[[:human genes:c:cope|COPE]]|0.434|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.433|
|[[:human genes:p:pan2|PAN2]]|0.433|
|[[:human genes:f:fam25b|FAM25B]]|0.432|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.43|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.43|
|[[:human genes:t:trappc5|TRAPPC5]]|0.43|
|[[:human genes:c:ctage9|CTAGE9]]|0.43|
|[[:human genes:e:eftud2|EFTUD2]]|0.429|
|[[:human genes:c:cgb2|CGB2]]|0.429|
|[[:human genes:d:disp2|DISP2]]|0.429|
|[[:human genes:n:narfl|NARFL]]|0.428|
|[[:human genes:p:polr2d|POLR2D]]|0.427|
|[[:human genes:g:golga8o|GOLGA8O]]|0.427|
|[[:human genes:p:ppm1d|PPM1D]]|0.427|
|[[:human genes:c:cbwd6|CBWD6]]|0.427|
|[[:human genes:s:snip1|SNIP1]]|0.426|
|[[:human genes:c:col2a1|COL2A1]]|0.425|
|[[:human genes:r:rps5|RPS5]]|0.424|
|[[:human genes:c:cep192|CEP192]]|0.423|
|[[:human genes:m:mfsd12|MFSD12]]|0.423|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.423|
|[[:human genes:p:polr2f|POLR2F]]|0.422|
|[[:human genes:p:psmd2|PSMD2]]|0.421|
|[[:human genes:s:slc6a17|SLC6A17]]|0.421|
|[[:human genes:c:c14orf93|C14orf93]]|0.421|
|[[:human genes:t:tspy8|TSPY8]]|0.42|
|[[:human genes:f:fbxw9|FBXW9]]|0.419|
|[[:human genes:p:psmc1|PSMC1]]|0.418|
|[[:human genes:p:pdcd7|PDCD7]]|0.418|
|[[:human genes:v:vasn|VASN]]|0.417|
|[[:human genes:s:snrpa1|SNRPA1]]|0.417|
|[[:human genes:c:copz1|COPZ1]]|0.416|
|[[:human genes:r:rfc1|RFC1]]|0.416|
|[[:human genes:e:exosc5|EXOSC5]]|0.415|
|[[:human genes:e:eif4a3|EIF4A3]]|0.415|
|[[:human genes:a:atxn1|ATXN1]]|0.415|
|[[:human genes:c:cdc73|CDC73]]|0.414|
|[[:human genes:a:aamp|AAMP]]|0.414|
|[[:human genes:m:med14|MED14]]|0.414|
|[[:human genes:o:osbp|OSBP]]|0.413|
|[[:human genes:i:ints5|INTS5]]|0.412|
|[[:human genes:t:tspy1|TSPY1]]|0.411|
|[[:human genes:t:taf1|TAF1]]|0.41|
|[[:human genes:c:cacna1a|CACNA1A]]|0.41|
|[[:human genes:s:supt6h|SUPT6H]]|0.409|
|[[:human genes:t:trappc11|TRAPPC11]]|0.408|
|[[:human genes:c:cdh24|CDH24]]|0.408|
|[[:human genes:d:ddtl|DDTL]]|0.407|
|[[:human genes:m:mtch2|MTCH2]]|0.406|
|[[:human genes:h:hivep3|HIVEP3]]|0.405|
|[[:human genes:e:exd1|EXD1]]|0.405|
|[[:human genes:n:nelfcd|NELFCD]]|0.405|
|[[:human genes:r:rpl35|RPL35]]|0.404|
|[[:human genes:s:syt9|SYT9]]|0.403|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.403|
|[[:human genes:r:rps19|RPS19]]|0.403|
|[[:human genes:s:ssh2|SSH2]]|0.402|
|[[:human genes:c:crnkl1|CRNKL1]]|0.402|
|[[:human genes:m:mphosph10|MPHOSPH10]]|0.401|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.401|
|[[:human genes:m:mat2a|MAT2A]]|0.401|
|[[:human genes:d:dock6|DOCK6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 310/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|13/28|
|blood|15/28|
|bone|13/25|
|breast|16/33|
|central nervous system|15/56|
|cervix|4/4|
|colorectal|5/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|9/15|
|kidney|6/21|
|liver|6/20|
|lung|26/75|
|lymphocyte|5/14|
|ovary|13/26|
|pancreas|7/24|
|peripheral nervous system|9/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|13/24|
|soft tissue|4/7|
|thyroid|0/2|
|upper aerodigestive|13/22|
|urinary tract|17/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1461
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.92 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSG101 Expression in NALM6 Cells: 4.92'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>