======= TSPO =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSPO
  * **<color #00a2e8>Official Name</color>**: translocator protein
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=706|706]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/"B1AH88|P30536"|"B1AH88|P30536"]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSPO&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSPO|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/109610|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TspO MBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|response to vitamin B1|
|androgen binding|
|maintenance of protein location in mitochondrion|
|peripheral nervous system axon regeneration|
|cellular hypotonic response|
|positive regulation of necrotic cell death|
|negative regulation of autophagy of mitochondrion|
|contact inhibition|
|hypotonic response|
|positive regulation of mitochondrial depolarization|
|benzodiazepine receptor activity|
|positive regulation of membrane depolarization|
|negative regulation of nitric oxide metabolic process|
|behavioral response to pain|
|negative regulation of glial cell proliferation|
|negative regulation of nitric oxide biosynthetic process|
|C21-steroid hormone biosynthetic process|
|positive regulation of glial cell proliferation|
|response to manganese ion|
|regulation of mitochondrial depolarization|
|heme biosynthetic process|
|axon regeneration|
|cellular response to zinc ion|
|adrenal gland development|
|negative regulation of ATP metabolic process|
|porphyrin-containing compound biosynthetic process|
|negative regulation of reactive oxygen species biosynthetic process|
|C21-steroid hormone metabolic process|
|tetrapyrrole biosynthetic process|
|regulation of necrotic cell death|
|neuron projection regeneration|
|regulation of glial cell proliferation|
|response to pain|
|heme metabolic process|
|cellular response to osmotic stress|
|glial cell migration|
|response to testosterone|
|porphyrin-containing compound metabolic process|
|maintenance of protein localization in organelle|
|negative regulation of gliogenesis|
|regulation of autophagy of mitochondrion|
|regulation of membrane depolarization|
|response to progesterone|
|regulation of cholesterol transport|
|regulation of sterol transport|
|steroid hormone biosynthetic process|
|pigment biosynthetic process|
|response to axon injury|
|cholesterol binding|
|negative regulation of mitochondrion organization|
|response to zinc ion|
|negative regulation of reactive oxygen species metabolic process|
|regulation of nitric oxide biosynthetic process|
|protein targeting to mitochondrion|
|tetrapyrrole metabolic process|
|negative regulation of tumor necrosis factor production|
|hormone biosynthetic process|
|negative regulation of tumor necrosis factor superfamily cytokine production|
|pigment metabolic process|
|multicellular organismal response to stress|
|positive regulation of gliogenesis|
|regulation of mitochondrial membrane potential|
|establishment of protein localization to mitochondrion|
|negative regulation of protein ubiquitination|
|maintenance of protein location in cell|
|response to osmotic stress|
|protein localization to mitochondrion|
|negative regulation of protein modification by small protein conjugation or removal|
|negative regulation of autophagy|
|regulation of reactive oxygen species biosynthetic process|
|response to vitamin|
|regulation of steroid biosynthetic process|
|maintenance of location in cell|
|positive regulation of reactive oxygen species metabolic process|
|chloride transport|
|maintenance of protein location|
|regulation of lipid transport|
|regulation of steroid metabolic process|
|regulation of gliogenesis|
|regulation of ATP metabolic process|
|cellular hormone metabolic process|
|positive regulation of calcium ion transport|
|endocrine system development|
|ion channel binding|
|steroid biosynthetic process|
|regulation of lipid localization|
|regulation of tumor necrosis factor production|
|regulation of tumor necrosis factor superfamily cytokine production|
|regeneration|
|inorganic anion transport|
|mitochondrial outer membrane|
|maintenance of location|
|regulation of reactive oxygen species metabolic process|
|regulation of mitochondrion organization|
|cellular response to lipopolysaccharide|
|regulation of lipid biosynthetic process|
|cellular response to metal ion|
|cellular response to molecule of bacterial origin|
|response to ketone|
|regulation of protein ubiquitination|
|hormone metabolic process|
|cofactor biosynthetic process|
|gliogenesis|
|mitochondrial transport|
|cellular response to biotic stimulus|
|response to nutrient|
|cellular response to inorganic substance|
|regulation of protein modification by small protein conjugation or removal|
|regulation of calcium ion transport|
|negative regulation of cellular catabolic process|
|steroid metabolic process|
|negative regulation of cytokine production|
|positive regulation of ion transport|
|aging|
|negative regulation of neurogenesis|
|lipid transport|
|negative regulation of catabolic process|
|negative regulation of nervous system development|
|cellular response to environmental stimulus|
|cellular response to abiotic stimulus|
|response to lipopolysaccharide|
|lipid localization|
|response to molecule of bacterial origin|
|response to steroid hormone|
|regulation of autophagy|
|negative regulation of cell development|
|regulation of neurotransmitter levels|
|protein targeting|
|response to metal ion|
|negative regulation of organelle organization|
|regulation of metal ion transport|
|regulation of lipid metabolic process|
|axon development|
|gland development|
|regulation of membrane potential|
|establishment of protein localization to organelle|
|cofactor metabolic process|
|mitochondrion organization|
|positive regulation of neurogenesis|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|regulation of hormone levels|
|response to inorganic substance|
|positive regulation of nervous system development|
|positive regulation of cell development|
|response to wounding|
|behavior|
|lipid biosynthetic process|
|anion transport|
|negative regulation of protein modification process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|neuron projection development|
|negative regulation of cell population proliferation|
|response to bacterium|
|regulation of cytokine production|
|positive regulation of cell death|
|regulation of ion transport|
|negative regulation of cellular component organization|
|negative regulation of cell differentiation|
|protein localization to organelle|
|ion homeostasis|
|neuron development|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|response to lipid|
|response to hormone|
|positive regulation of cell population proliferation|
|response to organic cyclic compound|
|regulation of nervous system development|
|regulation of cell development|
|negative regulation of developmental process|
|cell migration|
|positive regulation of cell differentiation|
|positive regulation of transport|
|regulation of catabolic process|
|intracellular protein transport|
|response to organonitrogen compound|
|neuron differentiation|
|endoplasmic reticulum|
|response to drug|
|negative regulation of cellular protein metabolic process|
|cellular response to oxygen-containing compound|
|localization of cell|
|cell motility|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|chemical homeostasis|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of multicellular organismal process|
|lipid metabolic process|
|regulation of organelle organization|
|response to other organism|
|organic cyclic compound biosynthetic process|
|response to external biotic stimulus|
|locomotion|
|response to biotic stimulus|
|positive regulation of developmental process|
|ion transport|
|organonitrogen compound biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|regulation of cell population proliferation|
|neurogenesis|
|cellular nitrogen compound biosynthetic process|
|homeostatic process|
|cell development|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp287|HMS-I2 5μM R06 exp287]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3852
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.59 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSPO Expression in NALM6 Cells: 1.59'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>