======= TSTA3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TSTA3
  * **<color #00a2e8>Official Name</color>**: tissue specific transplantation antigen P35B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7264|7264]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q13630|Q13630]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TSTA3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TSTA3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the two-step NADP-dependent conversion of GDP- 4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. {ECO:0000269|PubMed:8910301}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Epimerase|
|RmlD sub bind|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|GDP-4-dehydro-D-rhamnose reductase activity|
|GDP-L-fucose synthase activity|
|GDP-mannose 3,5-epimerase activity|
|de novo GDP-L-fucose biosynthetic process|
|GDP-L-fucose biosynthetic process|
|GDP-L-fucose metabolic process|
|GDP-mannose metabolic process|
|coenzyme binding|
|T cell mediated cytotoxicity|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|leukocyte mediated cytotoxicity|
|T cell mediated immunity|
|leukocyte cell-cell adhesion|
|electron transfer activity|
|cell killing|
|electron transport chain|
|lymphocyte mediated immunity|
|adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains|
|generation of precursor metabolites and energy|
|cell-cell adhesion|
|nucleobase-containing small molecule metabolic process|
|adaptive immune response|
|carbohydrate derivative biosynthetic process|
|leukocyte mediated immunity|
|cell adhesion|
|biological adhesion|
|oxidation-reduction process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|immune effector process|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
|immune response|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp134|MS023 2μM R03 exp134]]|-2.3|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.88|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|-1.87|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.75|
|[[:results:exp260|ABT-702 0.1μM R06 exp260]]|-1.74|
|[[:results:exp244|SB743921 0.001μM R05 exp244]]|-1.74|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|-1.72|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|1.77|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.79|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|2.01|
|[[:results:exp71|KU-0063794 3.8μM R02 exp71]]|2.05|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|2.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3309
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TSTA3 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>