======= TTI2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTI2
  * **<color #00a2e8>Official Name</color>**: TELO2 interacting protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=80185|80185]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6NXR4|Q6NXR4]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTI2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTI2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614426|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a regulator of the DNA damage response. The protein is a component of the Triple T complex (TTT) which also includes telomere length regulation protein and TELO2 interacting protein 1. The TTT complex is involved in cellular resistance to DNA damage stresses and may act as a regulator of phosphoinositide-3-kinase-related protein kinase (PIKK) abundance. [provided by RefSeq, May 2013]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Regulator of the DNA damage response (DDR). Part of the TTT complex that is required to stabilize protein levels of the phosphatidylinositol 3-kinase-related protein kinase (PIKK) family proteins. The TTT complex is involved in the cellular resistance to DNA damage stresses, like ionizing radiation (IR), ultraviolet (UV) and mitomycin C (MMC). Together with the TTT complex and HSP90 may participate in the proper folding of newly synthesized PIKKs. {ECO:0000269|PubMed:20801936, ECO:0000269|PubMed:20810650}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2454|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ASTRA complex|
|centrosome|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-2.09|
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-1.99|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|1.73|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.77|
|[[:results:exp108|Vinblastine 0.2μM R03 exp108]]|1.77|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|1.81|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|1.82|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.91|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|1.97|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.99|
|[[:results:exp17|DABN 20μM R00 exp17]]|2.03|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.11|
|[[:results:exp96|BI-2536 0.02μM R03 exp96]]|2.17|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|2.18|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.45|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|2.58|
|[[:results:exp22|MLN-4924 2μM R00 exp22]]|2.63|
|[[:results:exp531|THZ1 0.06μM R08 exp531]]|2.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gnb1l|GNB1L]]|0.713|
|[[:human genes:m:med16|MED16]]|0.66|
|[[:human genes:r:rptor|RPTOR]]|0.656|
|[[:human genes:t:telo2|TELO2]]|0.654|
|[[:human genes:t:tti1|TTI1]]|0.652|
|[[:human genes:a:aars|AARS]]|0.617|
|[[:human genes:r:rtcb|RTCB]]|0.608|
|[[:human genes:m:med23|MED23]]|0.595|
|[[:human genes:c:ccdc101|CCDC101]]|0.593|
|[[:human genes:r:rnmt|RNMT]]|0.59|
|[[:human genes:t:thg1l|THG1L]]|0.588|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.586|
|[[:human genes:d:dpagt1|DPAGT1]]|0.581|
|[[:human genes:g:gmppb|GMPPB]]|0.579|
|[[:human genes:m:mtor|MTOR]]|0.578|
|[[:human genes:c:csnk2b|CSNK2B]]|0.569|
|[[:human genes:o:otud5|OTUD5]]|0.562|
|[[:human genes:p:pmm2|PMM2]]|0.557|
|[[:human genes:d:dad1|DAD1]]|0.554|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.554|
|[[:human genes:g:gfpt1|GFPT1]]|0.549|
|[[:human genes:p:pelo|PELO]]|0.544|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.542|
|[[:human genes:r:rpp21|RPP21]]|0.54|
|[[:human genes:m:mllt1|MLLT1]]|0.539|
|[[:human genes:a:alg1|ALG1]]|0.537|
|[[:human genes:w:wdr24|WDR24]]|0.534|
|[[:human genes:t:tsen54|TSEN54]]|0.532|
|[[:human genes:t:trmt5|TRMT5]]|0.529|
|[[:human genes:p:polr3h|POLR3H]]|0.528|
|[[:human genes:e:eprs|EPRS]]|0.522|
|[[:human genes:m:mars|MARS]]|0.521|
|[[:human genes:a:adsl|ADSL]]|0.518|
|[[:human genes:c:cbfb|CBFB]]|0.517|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.516|
|[[:human genes:u:uap1|UAP1]]|0.516|
|[[:human genes:s:slc35b1|SLC35B1]]|0.516|
|[[:human genes:c:cct7|CCT7]]|0.515|
|[[:human genes:p:polr3b|POLR3B]]|0.512|
|[[:human genes:e:eif4e|EIF4E]]|0.506|
|[[:human genes:a:alg13|ALG13]]|0.506|
|[[:human genes:n:nae1|NAE1]]|0.504|
|[[:human genes:d:ddost|DDOST]]|0.503|
|[[:human genes:a:alg2|ALG2]]|0.502|
|[[:human genes:p:pam16|PAM16]]|0.501|
|[[:human genes:n:nars|NARS]]|0.501|
|[[:human genes:m:mapk14|MAPK14]]|0.498|
|[[:human genes:s:srp72|SRP72]]|0.497|
|[[:human genes:t:triap1|TRIAP1]]|0.496|
|[[:human genes:z:znf259|ZNF259]]|0.496|
|[[:human genes:d:ddx20|DDX20]]|0.495|
|[[:human genes:a:alg14|ALG14]]|0.494|
|[[:human genes:p:ppp4c|PPP4C]]|0.492|
|[[:human genes:m:meaf6|MEAF6]]|0.491|
|[[:human genes:u:ubr5|UBR5]]|0.49|
|[[:human genes:o:osgep|OSGEP]]|0.488|
|[[:human genes:s:srp68|SRP68]]|0.486|
|[[:human genes:t:tbca|TBCA]]|0.485|
|[[:human genes:t:thoc6|THOC6]]|0.483|
|[[:human genes:e:exoc4|EXOC4]]|0.482|
|[[:human genes:c:crcp|CRCP]]|0.482|
|[[:human genes:d:dohh|DOHH]]|0.476|
|[[:human genes:h:haus8|HAUS8]]|0.475|
|[[:human genes:t:tle4|TLE4]]|0.475|
|[[:human genes:w:wdr59|WDR59]]|0.474|
|[[:human genes:t:tsen34|TSEN34]]|0.473|
|[[:human genes:t:tbcb|TBCB]]|0.472|
|[[:human genes:d:dhps|DHPS]]|0.468|
|[[:human genes:a:atxn10|ATXN10]]|0.466|
|[[:human genes:s:srp14|SRP14]]|0.465|
|[[:human genes:c:cdipt|CDIPT]]|0.465|
|[[:human genes:v:vrk1|VRK1]]|0.464|
|[[:human genes:h:hspd1|HSPD1]]|0.464|
|[[:human genes:s:spcs3|SPCS3]]|0.462|
|[[:human genes:x:xpot|XPOT]]|0.461|
|[[:human genes:d:dr1|DR1]]|0.461|
|[[:human genes:t:trip12|TRIP12]]|0.459|
|[[:human genes:r:rpe|RPE]]|0.459|
|[[:human genes:f:fnta|FNTA]]|0.458|
|[[:human genes:h:hars|HARS]]|0.456|
|[[:human genes:v:vhl|VHL]]|0.455|
|[[:human genes:b:bap1|BAP1]]|0.454|
|[[:human genes:r:rpn1|RPN1]]|0.453|
|[[:human genes:u:uxt|UXT]]|0.452|
|[[:human genes:v:vmp1|VMP1]]|0.452|
|[[:human genes:s:seh1l|SEH1L]]|0.451|
|[[:human genes:l:lsmd1|LSMD1]]|0.451|
|[[:human genes:g:gemin8|GEMIN8]]|0.451|
|[[:human genes:s:spcs2|SPCS2]]|0.45|
|[[:human genes:a:alg5|ALG5]]|0.45|
|[[:human genes:v:vezt|VEZT]]|0.449|
|[[:human genes:c:cbx3|CBX3]]|0.449|
|[[:human genes:r:rad1|RAD1]]|0.448|
|[[:human genes:b:bub3|BUB3]]|0.447|
|[[:human genes:u:uhrf1|UHRF1]]|0.446|
|[[:human genes:l:lsm11|LSM11]]|0.446|
|[[:human genes:r:rbm14|RBM14]]|0.446|
|[[:human genes:y:yars|YARS]]|0.446|
|[[:human genes:a:atf7ip|ATF7IP]]|0.442|
|[[:human genes:m:med4|MED4]]|0.442|
|[[:human genes:n:nsmce1|NSMCE1]]|0.441|
|[[:human genes:p:pax5|PAX5]]|0.439|
|[[:human genes:t:tbcd|TBCD]]|0.438|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.436|
|[[:human genes:o:oraov1|ORAOV1]]|0.436|
|[[:human genes:s:snapc5|SNAPC5]]|0.435|
|[[:human genes:d:dpf2|DPF2]]|0.434|
|[[:human genes:c:cmtr1|CMTR1]]|0.434|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.428|
|[[:human genes:m:max|MAX]]|0.428|
|[[:human genes:z:znf608|ZNF608]]|0.427|
|[[:human genes:a:actr10|ACTR10]]|0.427|
|[[:human genes:d:dhdds|DHDDS]]|0.426|
|[[:human genes:g:gtf3a|GTF3A]]|0.425|
|[[:human genes:w:wars|WARS]]|0.425|
|[[:human genes:t:tgs1|TGS1]]|0.425|
|[[:human genes:d:ddx1|DDX1]]|0.424|
|[[:human genes:g:gemin6|GEMIN6]]|0.424|
|[[:human genes:p:pik3r4|PIK3R4]]|0.423|
|[[:human genes:t:tprkb|TPRKB]]|0.423|
|[[:human genes:s:smarcd1|SMARCD1]]|0.423|
|[[:human genes:t:trnt1|TRNT1]]|0.422|
|[[:human genes:g:gemin5|GEMIN5]]|0.421|
|[[:human genes:t:taf6l|TAF6L]]|0.42|
|[[:human genes:t:tsen2|TSEN2]]|0.42|
|[[:human genes:t:trim28|TRIM28]]|0.42|
|[[:human genes:t:tmem41b|TMEM41B]]|0.419|
|[[:human genes:e:eif3f|EIF3F]]|0.419|
|[[:human genes:u:ube2g2|UBE2G2]]|0.419|
|[[:human genes:s:snf8|SNF8]]|0.418|
|[[:human genes:t:tada1|TADA1]]|0.418|
|[[:human genes:e:eny2|ENY2]]|0.417|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.416|
|[[:human genes:a:alg6|ALG6]]|0.415|
|[[:human genes:d:dhx29|DHX29]]|0.412|
|[[:human genes:u:uba3|UBA3]]|0.41|
|[[:human genes:e:exoc3|EXOC3]]|0.41|
|[[:human genes:w:wdr82|WDR82]]|0.407|
|[[:human genes:n:nsd1|NSD1]]|0.406|
|[[:human genes:t:ttc4|TTC4]]|0.405|
|[[:human genes:p:pdap1|PDAP1]]|0.404|
|[[:human genes:u:ube2l3|UBE2L3]]|0.404|
|[[:human genes:n:nup50|NUP50]]|0.403|
|[[:human genes:x:xpo5|XPO5]]|0.402|
|[[:human genes:o:oip5|OIP5]]|0.402|
|[[:human genes:g:gpn2|GPN2]]|0.401|
|[[:human genes:d:dctn6|DCTN6]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 412/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|7/28|
|bone|15/26|
|breast|18/33|
|central nervous system|22/56|
|cervix|1/4|
|colorectal|9/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|10/16|
|kidney|10/21|
|liver|15/20|
|lung|49/75|
|lymphocyte|6/16|
|ovary|16/26|
|pancreas|14/24|
|peripheral nervous system|10/16|
|plasma cell|8/15|
|prostate|1/1|
|skin|11/24|
|soft tissue|4/9|
|thyroid|2/2|
|upper aerodigestive|16/22|
|urinary tract|19/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 537
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.05 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTI2 Expression in NALM6 Cells: 5.05'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>