======= TTL =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTL
  * **<color #00a2e8>Official Name</color>**: tubulin tyrosine ligase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=150465|150465]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NG68|Q8NG68]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTL&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTL|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/608291|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the post-translational addition of a tyrosine to the C-terminal end of detyrosinated alpha-tubulin. {ECO:0000269|PubMed:25908662}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TTL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tubulin-tyrosine ligase activity|
|C-terminal protein-tyrosinylation|
|protein tyrosinylation|
|regulation of metaphase plate congression|
|C-terminal protein amino acid modification|
|cell|
|regulation of axon extension|
|regulation of chromosome segregation|
|regulation of extent of cell growth|
|peptidyl-tyrosine modification|
|positive regulation of mitotic cell cycle|
|regulation of cell size|
|regulation of axonogenesis|
|regulation of cell morphogenesis involved in differentiation|
|regulation of developmental growth|
|post-translational protein modification|
|regulation of cellular component size|
|positive regulation of cell cycle|
|regulation of cell growth|
|microtubule cytoskeleton organization|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|regulation of anatomical structure size|
|regulation of mitotic cell cycle|
|regulation of neuron differentiation|
|regulation of growth|
|microtubule-based process|
|regulation of plasma membrane bounded cell projection organization|
|regulation of cell projection organization|
|regulation of cell cycle process|
|regulation of neurogenesis|
|peptidyl-amino acid modification|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|regulation of anatomical structure morphogenesis|
|cytoskeleton organization|
|regulation of cell cycle|
|ATP binding|
|generation of neurons|
|neurogenesis|
|regulation of cell differentiation|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-2.24|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.91|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.9|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.83|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.97|
|[[:results:exp155|UNC1999 2μM R03 exp155]]|1.97|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|2.19|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|2.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:k:katna1|KATNA1]]|0.437|
|[[:human genes:k:kif18b|KIF18B]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16347
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.86 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTL Expression in NALM6 Cells: 6.86'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>