======= TTLL6 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TTLL6
  * **<color #00a2e8>Official Name</color>**: tubulin tyrosine ligase like 6
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=284076|284076]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8N841|Q8N841]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TTLL6&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TTLL6|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610849|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Polyglutamylase which preferentially modifies alpha- tubulin. Mediates tubulin polyglutamylation in cilia. Involved in the side-chain elongation step of the polyglutamylation reaction rather than in the initiation step. Generates long side-chains. Generates polyglutamylation of CGAS, leading to impair the DNA- binding activity of CGAS. {ECO:0000250|UniProtKB:A4Q9E8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|TTL|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of cilium movement|
|protein-glutamic acid ligase activity|
|protein polyglutamylation|
|microtubule severing|
|regulation of cilium movement|
|peptidyl-glutamic acid modification|
|regulation of microtubule-based movement|
|tubulin binding|
|microtubule bundle formation|
|ciliary basal body|
|regulation of microtubule-based process|
|microtubule|
|microtubule cytoskeleton organization|
|positive regulation of cellular component movement|
|microtubule-based process|
|peptidyl-amino acid modification|
|regulation of cellular component movement|
|cytoskeleton organization|
|ATP binding|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp136|MS094 2μM R03 exp136]]|1.9|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2.21|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5850
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -2.69 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TTLL6 Expression in NALM6 Cells: -2.69'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>