======= TUBB =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUBB
  * **<color #00a2e8>Official Name</color>**: tubulin beta class I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=203068|203068]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P07437|P07437]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUBB&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUBB|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191130|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a beta tubulin protein. This protein forms a dimer with alpha tubulin and acts as a structural component of microtubules. Mutations in this gene cause cortical dysplasia, complex, with other brain malformations 6. Alternative splicing results in multiple splice variants. There are multiple pseudogenes for this gene on chromosomes 1, 6, 7, 8, 9, and 13. [provided by RefSeq, Jun 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Tubulin C|
|Tubulin|
|Misat Myo SegII|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear envelope lumen|
|GTPase activating protein binding|
|MHC class I protein binding|
|natural killer cell mediated cytotoxicity|
|natural killer cell mediated immunity|
|leukocyte mediated cytotoxicity|
|cytoplasmic ribonucleoprotein granule|
|cell body|
|cell killing|
|azurophil granule lumen|
|ciliary basal body-plasma membrane docking|
|spindle assembly|
|structural constituent of cytoskeleton|
|G2/M transition of mitotic cell cycle|
|cell cycle G2/M phase transition|
|spindle organization|
|organelle localization by membrane tethering|
|cytoskeleton-dependent intracellular transport|
|membrane docking|
|structural molecule activity|
|regulation of G2/M transition of mitotic cell cycle|
|regulation of cell cycle G2/M phase transition|
|regulation of synapse organization|
|membrane raft|
|regulation of synapse structure or activity|
|protein domain specific binding|
|lymphocyte mediated immunity|
|protein-containing complex binding|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|ubiquitin protein ligase binding|
|microtubule|
|GTPase activity|
|cilium assembly|
|cytoskeleton|
|cilium organization|
|GTP binding|
|regulation of mitotic cell cycle phase transition|
|plasma membrane bounded cell projection assembly|
|regulation of cell cycle phase transition|
|cell projection assembly|
|microtubule cytoskeleton organization|
|neutrophil degranulation|
|neutrophil activation involved in immune response|
|cell division|
|neutrophil mediated immunity|
|neutrophil activation|
|granulocyte activation|
|leukocyte degranulation|
|myeloid leukocyte mediated immunity|
|myeloid cell activation involved in immune response|
|organelle localization|
|myeloid leukocyte activation|
|mitotic cell cycle process|
|leukocyte activation involved in immune response|
|cell activation involved in immune response|
|regulation of mitotic cell cycle|
|microtubule-based process|
|mitotic cell cycle|
|regulated exocytosis|
|regulation of cell cycle process|
|organelle assembly|
|innate immune response|
|leukocyte mediated immunity|
|exocytosis|
|leukocyte activation|
|defense response to other organism|
|cell cycle process|
|secretion by cell|
|export from cell|
|cell activation|
|immune effector process|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|secretion|
|cell projection organization|
|regulation of cell cycle|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|cell cycle|
|defense response|
|intracellular transport|
|establishment of localization in cell|
|immune response|
|extracellular region|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp180|Dynasore 10μM R04 exp180]]|-2.75|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-2.66|
|[[:results:exp82|Torin1 0.08μM R02 exp82]]|-2.62|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|-2.55|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-2.33|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.3|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|-2.24|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.19|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-2.18|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-2.15|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-2.1|
|[[:results:exp445|∆-9-Tetrahydrocannabinol 30μM R08 exp445]]|-2.08|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|-2.07|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-1.99|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|-1.96|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|-1.85|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.83|
|[[:results:exp37|Wortmannin 0.5μM R00 exp37]]|-1.83|
|[[:results:exp526|Sulforaphane 9μM R08 exp526 no dilution day6]]|-1.79|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.78|
|[[:results:exp269|Bisphenol A 100μM R06 exp269]]|-1.75|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-1.72|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|1.7|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|2.2|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|3.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:stmn1|STMN1]]|0.477|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 690/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|28/28|
|bone|25/26|
|breast|32/33|
|central nervous system|55/56|
|cervix|4/4|
|colorectal|13/17|
|esophagus|12/13|
|fibroblast|1/1|
|gastric|14/16|
|kidney|21/21|
|liver|17/20|
|lung|69/75|
|lymphocyte|16/16|
|ovary|25/26|
|pancreas|23/24|
|peripheral nervous system|16/16|
|plasma cell|15/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|21/22|
|urinary tract|26/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 219
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 11.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUBB Expression in NALM6 Cells: 11.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>