======= TUFM =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUFM
  * **<color #00a2e8>Official Name</color>**: Tu translation elongation factor, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7284|7284]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P49411|P49411]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUFM&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUFM|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602389|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a protein which participates in protein translation in mitochondria. Mutations in this gene have been associated with combined oxidative phosphorylation deficiency resulting in lactic acidosis and fatal encephalopathy. A pseudogene has been identified on chromosome 17. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. Plays also a role in the regulation of autophagy and innate immunity. Recruits ATG5-ATG12 and NLRX1 at mitochondria and serves as a checkpoint of the RIG-I/DDX58-MAVS pathway. In turn, inhibits RLR-mediated type I interferon while promoting autophagy. {ECO:0000269|PubMed:22749352, ECO:0000269|PubMed:28407488}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|GTP EFTU|
|GTP EFTU D3|
|GTP EFTU D2|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|translation elongation factor activity|
|mitochondrial nucleoid|
|mitochondrial translational elongation|
|mitochondrial translation|
|translational elongation|
|response to ethanol|
|mitochondrial gene expression|
|response to alcohol|
|synapse|
|response to antibiotic|
|GTPase activity|
|translation|
|GTP binding|
|peptide biosynthetic process|
|response to toxic substance|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|response to drug|
|mitochondrion|
|RNA binding|
|organonitrogen compound biosynthetic process|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|membrane|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-2.24|
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-2.04|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.87|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|-1.82|
|[[:results:exp399|Salubrinal 20μM R07 exp399]]|-1.76|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|-1.74|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.73|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.72|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.78|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.83|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.86|
|[[:results:exp474|CR131-b 0.005μM R08 exp474]]|1.86|
|[[:results:exp469|CFI-400945 25μM R08 exp469]]|1.88|
|[[:results:exp451|Atovaquone 15μM R08 exp451]]|2.09|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.1|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|2.11|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|2.13|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.15|
|[[:results:exp228|Demecolcine 0.03μM R05 exp228]]|2.2|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|2.21|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.62|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hsd17b10|HSD17B10]]|0.691|
|[[:human genes:m:mrpl21|MRPL21]]|0.69|
|[[:human genes:m:mrps14|MRPS14]]|0.674|
|[[:human genes:g:gfm1|GFM1]]|0.66|
|[[:human genes:p:pnpt1|PNPT1]]|0.63|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.628|
|[[:human genes:y:yars2|YARS2]]|0.625|
|[[:human genes:m:mrps5|MRPS5]]|0.613|
|[[:human genes:m:mrps34|MRPS34]]|0.609|
|[[:human genes:d:dap3|DAP3]]|0.609|
|[[:human genes:s:sars2|SARS2]]|0.607|
|[[:human genes:c:cox16|COX16]]|0.606|
|[[:human genes:m:mrpl15|MRPL15]]|0.605|
|[[:human genes:d:dars2|DARS2]]|0.598|
|[[:human genes:b:bcs1l|BCS1L]]|0.598|
|[[:human genes:r:rpusd4|RPUSD4]]|0.597|
|[[:human genes:m:mrps21|MRPS21]]|0.597|
|[[:human genes:m:mrp63|MRP63]]|0.591|
|[[:human genes:t:tars2|TARS2]]|0.588|
|[[:human genes:m:mrps16|MRPS16]]|0.585|
|[[:human genes:s:sco2|SCO2]]|0.584|
|[[:human genes:m:mrpl47|MRPL47]]|0.58|
|[[:human genes:m:mrpl53|MRPL53]]|0.577|
|[[:human genes:e:elac2|ELAC2]]|0.577|
|[[:human genes:n:ndufa3|NDUFA3]]|0.576|
|[[:human genes:v:vars2|VARS2]]|0.574|
|[[:human genes:s:slc25a26|SLC25A26]]|0.572|
|[[:human genes:m:mars2|MARS2]]|0.57|
|[[:human genes:m:mrpl23|MRPL23]]|0.57|
|[[:human genes:f:fastkd5|FASTKD5]]|0.566|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.562|
|[[:human genes:u:uqcr10|UQCR10]]|0.561|
|[[:human genes:n:ndufb11|NDUFB11]]|0.556|
|[[:human genes:m:mrps18a|MRPS18A]]|0.555|
|[[:human genes:c:c10orf2|C10orf2]]|0.553|
|[[:human genes:m:mrps33|MRPS33]]|0.552|
|[[:human genes:m:mrps6|MRPS6]]|0.551|
|[[:human genes:m:mrps9|MRPS9]]|0.55|
|[[:human genes:m:mrpl45|MRPL45]]|0.55|
|[[:human genes:r:rbfa|RBFA]]|0.549|
|[[:human genes:m:mrps2|MRPS2]]|0.547|
|[[:human genes:f:fars2|FARS2]]|0.545|
|[[:human genes:s:selrc1|SELRC1]]|0.544|
|[[:human genes:h:hccs|HCCS]]|0.543|
|[[:human genes:m:mrps26|MRPS26]]|0.541|
|[[:human genes:m:mrps11|MRPS11]]|0.537|
|[[:human genes:m:mrpl20|MRPL20]]|0.537|
|[[:human genes:n:nars2|NARS2]]|0.532|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.529|
|[[:human genes:c:cycs|CYCS]]|0.527|
|[[:human genes:r:rars2|RARS2]]|0.527|
|[[:human genes:p:pars2|PARS2]]|0.524|
|[[:human genes:t:trub2|TRUB2]]|0.524|
|[[:human genes:m:mrpl34|MRPL34]]|0.522|
|[[:human genes:m:mrpl3|MRPL3]]|0.521|
|[[:human genes:q:qrsl1|QRSL1]]|0.521|
|[[:human genes:c:cox7b|COX7B]]|0.517|
|[[:human genes:m:mrps25|MRPS25]]|0.516|
|[[:human genes:t:tefm|TEFM]]|0.515|
|[[:human genes:n:ndufa2|NDUFA2]]|0.514|
|[[:human genes:e:ears2|EARS2]]|0.513|
|[[:human genes:p:pdss1|PDSS1]]|0.51|
|[[:human genes:a:atp5c1|ATP5C1]]|0.507|
|[[:human genes:m:mrps23|MRPS23]]|0.505|
|[[:human genes:h:hars2|HARS2]]|0.502|
|[[:human genes:m:mrps24|MRPS24]]|0.502|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.501|
|[[:human genes:t:triap1|TRIAP1]]|0.5|
|[[:human genes:c:c17orf89|C17orf89]]|0.496|
|[[:human genes:g:gfm2|GFM2]]|0.495|
|[[:human genes:n:ndufa1|NDUFA1]]|0.495|
|[[:human genes:w:wbscr16|WBSCR16]]|0.494|
|[[:human genes:t:tfam|TFAM]]|0.494|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.493|
|[[:human genes:a:atp5j|ATP5J]]|0.492|
|[[:human genes:c:chchd4|CHCHD4]]|0.492|
|[[:human genes:g:gatc|GATC]]|0.49|
|[[:human genes:m:mrps17|MRPS17]]|0.489|
|[[:human genes:c:c12orf65|C12orf65]]|0.489|
|[[:human genes:n:ndufb3|NDUFB3]]|0.487|
|[[:human genes:d:dohh|DOHH]]|0.487|
|[[:human genes:m:mrpl55|MRPL55]]|0.487|
|[[:human genes:c:coa5|COA5]]|0.486|
|[[:human genes:t:trmt10c|TRMT10C]]|0.484|
|[[:human genes:c:cox17|COX17]]|0.483|
|[[:human genes:a:atp5d|ATP5D]]|0.482|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.482|
|[[:human genes:n:ndufs7|NDUFS7]]|0.481|
|[[:human genes:m:mrpl36|MRPL36]]|0.48|
|[[:human genes:m:mrps12|MRPS12]]|0.479|
|[[:human genes:t:tomm20|TOMM20]]|0.479|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.479|
|[[:human genes:m:mrpl43|MRPL43]]|0.479|
|[[:human genes:m:mtpap|MTPAP]]|0.478|
|[[:human genes:l:lars2|LARS2]]|0.478|
|[[:human genes:l:lsm10|LSM10]]|0.476|
|[[:human genes:n:ndufb9|NDUFB9]]|0.475|
|[[:human genes:p:ppa2|PPA2]]|0.474|
|[[:human genes:m:mrpl42|MRPL42]]|0.472|
|[[:human genes:c:cox6c|COX6C]]|0.471|
|[[:human genes:m:mrpl12|MRPL12]]|0.47|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.47|
|[[:human genes:a:atp5b|ATP5B]]|0.469|
|[[:human genes:m:mrpl13|MRPL13]]|0.468|
|[[:human genes:r:rpusd3|RPUSD3]]|0.467|
|[[:human genes:t:tomm22|TOMM22]]|0.466|
|[[:human genes:a:atp5sl|ATP5SL]]|0.464|
|[[:human genes:n:ndufc2|NDUFC2]]|0.463|
|[[:human genes:a:atp5a1|ATP5A1]]|0.462|
|[[:human genes:n:ndufb5|NDUFB5]]|0.461|
|[[:human genes:f:ftsj2|FTSJ2]]|0.46|
|[[:human genes:m:mrpl44|MRPL44]]|0.459|
|[[:human genes:d:dhrsx|DHRSX]]|0.459|
|[[:human genes:t:tmem242|TMEM242]]|0.459|
|[[:human genes:t:tomm40|TOMM40]]|0.456|
|[[:human genes:m:mtg1|MTG1]]|0.455|
|[[:human genes:p:pmm2|PMM2]]|0.455|
|[[:human genes:m:mrpl38|MRPL38]]|0.454|
|[[:human genes:s:slc25a19|SLC25A19]]|0.454|
|[[:human genes:u:uhrf1|UHRF1]]|0.451|
|[[:human genes:m:mrps22|MRPS22]]|0.451|
|[[:human genes:v:vezt|VEZT]]|0.451|
|[[:human genes:n:ndufs2|NDUFS2]]|0.45|
|[[:human genes:n:ndufb6|NDUFB6]]|0.449|
|[[:human genes:r:rpe|RPE]]|0.448|
|[[:human genes:n:ndufv1|NDUFV1]]|0.448|
|[[:human genes:u:uqcrq|UQCRQ]]|0.448|
|[[:human genes:t:tamm41|TAMM41]]|0.446|
|[[:human genes:t:taz|TAZ]]|0.444|
|[[:human genes:p:ppcs|PPCS]]|0.444|
|[[:human genes:s:slc25a3|SLC25A3]]|0.444|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.444|
|[[:human genes:m:mrpl27|MRPL27]]|0.443|
|[[:human genes:p:pgm3|PGM3]]|0.443|
|[[:human genes:m:mtg2|MTG2]]|0.443|
|[[:human genes:d:dhx30|DHX30]]|0.443|
|[[:human genes:l:lamtor4|LAMTOR4]]|0.441|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.441|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.441|
|[[:human genes:u:uap1|UAP1]]|0.44|
|[[:human genes:c:coq2|COQ2]]|0.44|
|[[:human genes:m:mterfd1|MTERFD1]]|0.439|
|[[:human genes:c:coa3|COA3]]|0.435|
|[[:human genes:m:mrps7|MRPS7]]|0.435|
|[[:human genes:m:mrpl33|MRPL33]]|0.433|
|[[:human genes:p:polg|POLG]]|0.433|
|[[:human genes:g:gfpt1|GFPT1]]|0.433|
|[[:human genes:m:mrps10|MRPS10]]|0.432|
|[[:human genes:m:mrpl18|MRPL18]]|0.431|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.431|
|[[:human genes:c:chchd1|CHCHD1]]|0.431|
|[[:human genes:d:dpagt1|DPAGT1]]|0.43|
|[[:human genes:i:iba57|IBA57]]|0.429|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.427|
|[[:human genes:n:ndufa11|NDUFA11]]|0.426|
|[[:human genes:m:mipep|MIPEP]]|0.426|
|[[:human genes:m:mettl17|METTL17]]|0.425|
|[[:human genes:t:thg1l|THG1L]]|0.425|
|[[:human genes:m:mrpl4|MRPL4]]|0.425|
|[[:human genes:c:cox15|COX15]]|0.424|
|[[:human genes:n:ndufa10|NDUFA10]]|0.422|
|[[:human genes:a:atp5o|ATP5O]]|0.422|
|[[:human genes:a:aars2|AARS2]]|0.422|
|[[:human genes:m:mrpl39|MRPL39]]|0.422|
|[[:human genes:a:atxn10|ATXN10]]|0.421|
|[[:human genes:m:mrpl51|MRPL51]]|0.421|
|[[:human genes:i:isca2|ISCA2]]|0.42|
|[[:human genes:r:rpia|RPIA]]|0.42|
|[[:human genes:c:crls1|CRLS1]]|0.418|
|[[:human genes:a:alas1|ALAS1]]|0.418|
|[[:human genes:s:ssb|SSB]]|0.416|
|[[:human genes:c:cox11|COX11]]|0.415|
|[[:human genes:n:ndufa5|NDUFA5]]|0.415|
|[[:human genes:t:trnt1|TRNT1]]|0.414|
|[[:human genes:p:polg2|POLG2]]|0.414|
|[[:human genes:p:pet112|PET112]]|0.414|
|[[:human genes:m:mrpl46|MRPL46]]|0.413|
|[[:human genes:c:coq7|COQ7]]|0.412|
|[[:human genes:f:fech|FECH]]|0.411|
|[[:human genes:m:mrpl32|MRPL32]]|0.409|
|[[:human genes:s:sdha|SDHA]]|0.407|
|[[:human genes:m:mrpl52|MRPL52]]|0.407|
|[[:human genes:a:aifm1|AIFM1]]|0.405|
|[[:human genes:o:opa1|OPA1]]|0.404|
|[[:human genes:c:coq3|COQ3]]|0.404|
|[[:human genes:m:mbtps2|MBTPS2]]|0.404|
|[[:human genes:b:bap1|BAP1]]|0.404|
|[[:human genes:a:atic|ATIC]]|0.403|
|[[:human genes:c:coq6|COQ6]]|0.403|
|[[:human genes:n:nfu1|NFU1]]|0.403|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.402|
|[[:human genes:c:cox6b1|COX6B1]]|0.401|
|[[:human genes:a:alg1|ALG1]]|0.4|
|[[:human genes:v:vps41|VPS41]]|0.4|
|[[:human genes:f:fh|FH]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 151
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.63 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUFM Expression in NALM6 Cells: 8.63'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>