======= TUSC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TUSC2
  * **<color #00a2e8>Official Name</color>**: tumor suppressor 2, mitochondrial calcium regulator
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=11334|11334]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75896|O75896]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TUSC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TUSC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607052|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|interleukin-15 production|
|response to defense-related host reactive oxygen species production|
|response to defense-related reactive oxygen species production by other organism involved in symbiotic interaction|
|chemokine (C-C motif) ligand 5 production|
|neutrophil mediated killing of gram-negative bacterium|
|neutrophil mediated killing of bacterium|
|neutrophil mediated killing of symbiont cell|
|response to immune response of other organism involved in symbiotic interaction|
|response to host immune response|
|neutrophil mediated cytotoxicity|
|response to host defenses|
|response to defenses of other organism involved in symbiotic interaction|
|response to host|
|natural killer cell differentiation|
|killing by host of symbiont cells|
|chemokine production|
|disruption by host of symbiont cells|
|killing of cells in other organism involved in symbiotic interaction|
|disruption of cells of other organism involved in symbiotic interaction|
|negative regulation of interleukin-17 production|
|regulation of interleukin-17 production|
|positive regulation of interleukin-10 production|
|leukocyte mediated cytotoxicity|
|killing of cells of other organism|
|disruption of cells of other organism|
|regulation of interleukin-10 production|
|natural killer cell activation|
|regulation of mitochondrial membrane potential|
|modification by host of symbiont morphology or physiology|
|interaction with symbiont|
|defense response to Gram-negative bacterium|
|cell killing|
|modification of morphology or physiology of other organism involved in symbiotic interaction|
|cytokine production|
|modification of morphology or physiology of other organism|
|interaction with host|
|cell maturation|
|regulation of reactive oxygen species metabolic process|
|lymphocyte differentiation|
|developmental maturation|
|negative regulation of cytokine production|
|phagocytosis|
|defense response to bacterium|
|leukocyte differentiation|
|lymphocyte activation|
|regulation of membrane potential|
|positive regulation of cytokine production|
|neutrophil mediated immunity|
|inflammatory response|
|myeloid leukocyte mediated immunity|
|hemopoiesis|
|hematopoietic or lymphoid organ development|
|immune system development|
|response to bacterium|
|regulation of cytokine production|
|leukocyte mediated immunity|
|symbiotic process|
|interspecies interaction between organisms|
|leukocyte activation|
|defense response to other organism|
|cell activation|
|immune effector process|
|negative regulation of multicellular organismal process|
|mitochondrion|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|cell cycle|
|cell development|
|positive regulation of multicellular organismal process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.73|
|[[:results:exp134|MS023 2μM R03 exp134]]|-1.7|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18075
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TUSC2 Expression in NALM6 Cells: 4.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>