======= TXNDC11 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNDC11
  * **<color #00a2e8>Official Name</color>**: thioredoxin domain containing 11
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51061|51061]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q6PKC3|Q6PKC3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNDC11&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNDC11|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617792|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May act as a redox regulator involved in DUOX proteins folding. The interaction with DUOX1 and DUOX2 suggest that it belongs to a multiprotein complex constituting the thyroid H(2)O(2) generating system. It is however not sufficient to assist DUOX1 and DUOX2 in H(2)O(2) generation.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Thioredoxin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cell redox homeostasis|
|cellular homeostasis|
|endoplasmic reticulum membrane|
|homeostatic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|-1.91|
|[[:results:exp363|GSK-J4 1-1.25μM to day4 R07 exp363]]|-1.89|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.88|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|-1.85|
|[[:results:exp146|Quinacrine 2.5μM R03 exp146]]|-1.77|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|1.82|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|1.88|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.88|
|[[:results:exp530|Thioridazine 5μM R08 exp530]]|1.9|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.93|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.99|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.05|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|2.06|
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|2.06|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|2.18|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11340
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.48 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNDC11 Expression in NALM6 Cells: 5.48'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>