======= TXNL4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TXNL4B
  * **<color #00a2e8>Official Name</color>**: thioredoxin like 4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=54957|54957]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NX01|Q9NX01]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TXNL4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TXNL4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617722|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition. {ECO:0000269|PubMed:15161931}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DIM1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|U5 snRNP|
|U4/U6 x U5 tri-snRNP complex|
|mRNA splicing, via spliceosome|
|RNA splicing, via transesterification reactions with bulged adenosine as nucleophile|
|RNA splicing, via transesterification reactions|
|RNA splicing|
|mRNA processing|
|mRNA metabolic process|
|RNA processing|
|cell cycle|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp375|Lenalidomide 20μM R07 exp375]]|-2.39|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-2.19|
|[[:results:exp406|Thalidomide 20μM R07 exp406]]|-2.12|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|-2.11|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|-2.1|
|[[:results:exp53|Suberoylanilide-Hydroxamic-Acid 0.02μM R01 exp53]]|-2.1|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|-2.06|
|[[:results:exp16|DABN 2μM R00 exp16]]|-2.02|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.99|
|[[:results:exp332|Adefovir 20μM R07 exp332]]|-1.97|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|-1.91|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.84|
|[[:results:exp50|Nicotinamide 2000μM R01 exp50]]|-1.81|
|[[:results:exp310|2-Methoxyestradiol 0.55μM R07 exp310]]|-1.78|
|[[:results:exp128|GSK591 2.6μM R03 exp128]]|-1.78|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|-1.77|
|[[:results:exp341|BRD2 inhibitor II 20μM R07 exp341]]|-1.73|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-1.73|
|[[:results:exp473|Cincreasin 100μM R08 exp473]]|-1.71|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.7|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|1.73|
|[[:results:exp288|HMS-I2 10μM R06 exp288]]|1.8|
|[[:results:exp401|SNS-032 25μM R07 exp401]]|2.31|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.527|
|[[:human genes:a:adsl|ADSL]]|0.521|
|[[:human genes:t:thg1l|THG1L]]|0.515|
|[[:human genes:t:triap1|TRIAP1]]|0.509|
|[[:human genes:a:alg1|ALG1]]|0.489|
|[[:human genes:u:uap1|UAP1]]|0.485|
|[[:human genes:e:exoc4|EXOC4]]|0.483|
|[[:human genes:v:vezt|VEZT]]|0.481|
|[[:human genes:g:gemin7|GEMIN7]]|0.472|
|[[:human genes:r:rnmt|RNMT]]|0.471|
|[[:human genes:r:rpp21|RPP21]]|0.469|
|[[:human genes:a:alg13|ALG13]]|0.468|
|[[:human genes:c:chchd4|CHCHD4]]|0.468|
|[[:human genes:r:rpe|RPE]]|0.467|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.464|
|[[:human genes:u:utp23|UTP23]]|0.464|
|[[:human genes:e:elac2|ELAC2]]|0.463|
|[[:human genes:p:pmm2|PMM2]]|0.462|
|[[:human genes:g:gmppb|GMPPB]]|0.462|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.46|
|[[:human genes:r:rad1|RAD1]]|0.456|
|[[:human genes:h:haus8|HAUS8]]|0.455|
|[[:human genes:r:rptor|RPTOR]]|0.452|
|[[:human genes:u:urm1|URM1]]|0.452|
|[[:human genes:n:naf1|NAF1]]|0.449|
|[[:human genes:d:dpagt1|DPAGT1]]|0.446|
|[[:human genes:g:gemin5|GEMIN5]]|0.445|
|[[:human genes:t:trmt5|TRMT5]]|0.445|
|[[:human genes:d:ddx20|DDX20]]|0.443|
|[[:human genes:a:atxn10|ATXN10]]|0.436|
|[[:human genes:r:rtcb|RTCB]]|0.436|
|[[:human genes:u:uhrf1|UHRF1]]|0.435|
|[[:human genes:d:dhps|DHPS]]|0.434|
|[[:human genes:n:nae1|NAE1]]|0.433|
|[[:human genes:n:nsmce1|NSMCE1]]|0.432|
|[[:human genes:h:hspd1|HSPD1]]|0.432|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.431|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.428|
|[[:human genes:t:ten1|TEN1]]|0.426|
|[[:human genes:n:naa20|NAA20]]|0.424|
|[[:human genes:s:ssb|SSB]]|0.423|
|[[:human genes:e:eftud1|EFTUD1]]|0.422|
|[[:human genes:s:spr|SPR]]|0.422|
|[[:human genes:u:uxt|UXT]]|0.421|
|[[:human genes:t:tpk1|TPK1]]|0.419|
|[[:human genes:s:slc25a26|SLC25A26]]|0.419|
|[[:human genes:t:tbca|TBCA]]|0.419|
|[[:human genes:u:uqcr10|UQCR10]]|0.419|
|[[:human genes:t:trmt10a|TRMT10A]]|0.417|
|[[:human genes:t:taf1a|TAF1A]]|0.417|
|[[:human genes:e:exoc3|EXOC3]]|0.416|
|[[:human genes:g:gfpt1|GFPT1]]|0.416|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.416|
|[[:human genes:s:srp14|SRP14]]|0.414|
|[[:human genes:t:ttc4|TTC4]]|0.412|
|[[:human genes:z:zrsr2|ZRSR2]]|0.412|
|[[:human genes:p:ppcs|PPCS]]|0.411|
|[[:human genes:t:trnt1|TRNT1]]|0.411|
|[[:human genes:f:fnta|FNTA]]|0.408|
|[[:human genes:m:msto1|MSTO1]]|0.407|
|[[:human genes:d:dohh|DOHH]]|0.405|
|[[:human genes:g:gemin6|GEMIN6]]|0.405|
|[[:human genes:a:atp5b|ATP5B]]|0.405|
|[[:human genes:s:spcs3|SPCS3]]|0.403|
|[[:human genes:b:bcs1l|BCS1L]]|0.403|
|[[:human genes:a:alg5|ALG5]]|0.402|
|[[:human genes:r:romo1|ROMO1]]|0.402|
|[[:human genes:d:ddx55|DDX55]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 84/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|5/28|
|blood|4/28|
|bone|6/26|
|breast|8/33|
|central nervous system|5/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|1/1|
|gastric|3/16|
|kidney|1/21|
|liver|1/20|
|lung|5/75|
|lymphocyte|3/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|0/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3231
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.37 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TXNL4B Expression in NALM6 Cells: 4.37'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>