======= TYRO3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: TYRO3
  * **<color #00a2e8>Official Name</color>**: TYRO3 protein tyrosine kinase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7301|7301]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q06418|Q06418]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=TYRO3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20TYRO3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600341|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The gene is part of a 3-member transmembrane receptor kinase receptor family with a processed pseudogene distal on chromosome 15. The encoded protein is activated by the products of the growth arrest-specific gene 6 and protein S genes and is involved in controlling cell survival and proliferation, spermatogenesis, immunoregulation and phagocytosis. The encoded protein has also been identified as a cell entry factor for Ebola and Marburg viruses. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including TULP1 or GAS6. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces dimerization and autophosphorylation of TYRO3 on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with PIK3R1 and thereby enhances PI3-kinase activity. Activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and up-regulation of transcription of NF-kappa-B-regulated genes. TYRO3 signaling plays a role in various processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeleton reorganization. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3. {ECO:0000269|PubMed:20546121}. (Microbial infection) Acts as a receptor for Ebolavirus, possibly through GAS6 binding to phosphatidyl-serine at the surface of virion envelope. {ECO:0000269|PubMed:17005688}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|I-set|
|Pkinase Tyr|
|ig|
|Pkinase|
|fn3|
|V-set|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|natural killer cell differentiation|
|vagina development|
|female genitalia development|
|phosphatidylinositol 3-kinase binding|
|phosphatidylinositol 3-kinase signaling|
|neuron cellular homeostasis|
|Wnt-protein binding|
|protein kinase B signaling|
|apoptotic cell clearance|
|negative regulation of toll-like receptor signaling pathway|
|platelet aggregation|
|genitalia development|
|substrate adhesion-dependent cell spreading|
|transmembrane receptor protein tyrosine kinase activity|
|negative regulation of innate immune response|
|natural killer cell activation|
|homotypic cell-cell adhesion|
|forebrain cell migration|
|ovulation cycle|
|regulation of toll-like receptor signaling pathway|
|phosphatidylinositol-mediated signaling|
|inositol lipid-mediated signaling|
|virus receptor activity|
|protein tyrosine kinase activity|
|negative regulation of response to biotic stimulus|
|viral entry into host cell|
|entry into host cell|
|entry into host|
|neuropeptide signaling pathway|
|female sex differentiation|
|negative regulation of inflammatory response|
|platelet activation|
|peptidyl-tyrosine phosphorylation|
|negative regulation of lymphocyte activation|
|negative regulation of neuron apoptotic process|
|peptidyl-tyrosine modification|
|negative regulation of immune response|
|interaction with host|
|negative regulation of leukocyte activation|
|nuclear envelope|
|cell-substrate adhesion|
|protein autophosphorylation|
|negative regulation of cell activation|
|viral life cycle|
|receptor complex|
|regulation of neuron apoptotic process|
|negative regulation of neuron death|
|negative regulation of defense response|
|negative regulation of multi-organism process|
|lymphocyte differentiation|
|sex differentiation|
|rhythmic process|
|blood coagulation|
|coagulation|
|hemostasis|
|regulation of neuron death|
|phagocytosis|
|leukocyte differentiation|
|regulation of inflammatory response|
|anatomical structure homeostasis|
|Wnt signaling pathway|
|cell-cell signaling by wnt|
|negative regulation of response to external stimulus|
|lymphocyte activation|
|forebrain development|
|reproductive structure development|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|reproductive system development|
|negative regulation of immune system process|
|regulation of innate immune response|
|wound healing|
|protein heterodimerization activity|
|regulation of body fluid levels|
|cell-cell adhesion|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|regulation of lymphocyte activation|
|regulation of response to biotic stimulus|
|spermatogenesis|
|cell morphogenesis involved in differentiation|
|hemopoiesis|
|male gamete generation|
|response to wounding|
|regulation of leukocyte activation|
|hematopoietic or lymphoid organ development|
|cell surface|
|regulation of cell activation|
|immune system development|
|developmental process involved in reproduction|
|gamete generation|
|viral process|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|brain development|
|regulation of defense response|
|regulation of multi-organism process|
|head development|
|symbiotic process|
|interspecies interaction between organisms|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|peptidyl-amino acid modification|
|negative regulation of apoptotic process|
|cellular homeostasis|
|negative regulation of programmed cell death|
|leukocyte activation|
|cell adhesion|
|biological adhesion|
|endoplasmic reticulum membrane|
|cell migration|
|protein phosphorylation|
|central nervous system development|
|multi-organism reproductive process|
|negative regulation of cell death|
|secretion by cell|
|export from cell|
|cell activation|
|localization of cell|
|cell motility|
|regulation of response to external stimulus|
|cell-cell signaling|
|secretion|
|regulation of immune response|
|negative regulation of signal transduction|
|phosphorylation|
|locomotion|
|G protein-coupled receptor signaling pathway|
|negative regulation of cell communication|
|negative regulation of signaling|
|integral component of plasma membrane|
|reproductive process|
|reproduction|
|regulation of response to stress|
|ATP binding|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|negative regulation of response to stimulus|
|homeostatic process|
|cell development|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp156|UNC2400 2μM R03 exp156]]|-1.7|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|1.84|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3280
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.14 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='TYRO3 Expression in NALM6 Cells: 5.14'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>