======= UAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UAP1
  * **<color #00a2e8>Official Name</color>**: UDP-N-acetylglucosamine pyrophosphorylase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=6675|6675]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16222|Q16222]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602862|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Converts UTP and GlcNAc-1-P into UDP-GlcNAc, and UTP and GalNAc-1-P into UDP-GalNAc. Isoform AGX1 has 2 to 3 times higher activity towards GalNAc-1-P, while isoform AGX2 has 8 times more activity towards GlcNAc-1-P.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDPGP|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-N-acetylglucosamine diphosphorylase activity|
|UDP-N-acetylglucosamine biosynthetic process|
|amino sugar biosynthetic process|
|UDP-N-acetylglucosamine metabolic process|
|nucleotide-sugar biosynthetic process|
|nucleotide-sugar metabolic process|
|amino sugar metabolic process|
|carbohydrate binding|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|carbohydrate derivative metabolic process|
|identical protein binding|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|-1.9|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-1.84|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.72|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.76|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.78|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|1.82|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|1.89|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|2.13|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:g:gfpt1|GFPT1]]|0.747|
|[[:human genes:t:thg1l|THG1L]]|0.72|
|[[:human genes:d:dpagt1|DPAGT1]]|0.708|
|[[:human genes:p:pmm2|PMM2]]|0.695|
|[[:human genes:a:alg1|ALG1]]|0.682|
|[[:human genes:t:triap1|TRIAP1]]|0.681|
|[[:human genes:g:gmppb|GMPPB]]|0.671|
|[[:human genes:d:dohh|DOHH]]|0.663|
|[[:human genes:r:rtcb|RTCB]]|0.658|
|[[:human genes:r:rptor|RPTOR]]|0.63|
|[[:human genes:h:hccs|HCCS]]|0.622|
|[[:human genes:a:alg13|ALG13]]|0.619|
|[[:human genes:a:atxn10|ATXN10]]|0.615|
|[[:human genes:h:hspd1|HSPD1]]|0.607|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.605|
|[[:human genes:t:tsen54|TSEN54]]|0.605|
|[[:human genes:u:uhrf1|UHRF1]]|0.599|
|[[:human genes:e:exoc4|EXOC4]]|0.598|
|[[:human genes:a:alg2|ALG2]]|0.597|
|[[:human genes:r:rpp21|RPP21]]|0.595|
|[[:human genes:h:hars|HARS]]|0.593|
|[[:human genes:s:srp14|SRP14]]|0.593|
|[[:human genes:a:atp5j|ATP5J]]|0.588|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.585|
|[[:human genes:r:romo1|ROMO1]]|0.583|
|[[:human genes:n:nae1|NAE1]]|0.581|
|[[:human genes:a:alg5|ALG5]]|0.579|
|[[:human genes:o:oraov1|ORAOV1]]|0.578|
|[[:human genes:r:rnmt|RNMT]]|0.577|
|[[:human genes:t:tamm41|TAMM41]]|0.577|
|[[:human genes:e:eny2|ENY2]]|0.572|
|[[:human genes:a:adsl|ADSL]]|0.569|
|[[:human genes:p:ppcs|PPCS]]|0.567|
|[[:human genes:d:dhps|DHPS]]|0.567|
|[[:human genes:v:vezt|VEZT]]|0.566|
|[[:human genes:e:eif4e|EIF4E]]|0.56|
|[[:human genes:r:rpe|RPE]]|0.557|
|[[:human genes:a:apaf1|APAF1]]|0.554|
|[[:human genes:d:dhrsx|DHRSX]]|0.554|
|[[:human genes:t:trnt1|TRNT1]]|0.552|
|[[:human genes:c:casp9|CASP9]]|0.552|
|[[:human genes:p:pelo|PELO]]|0.547|
|[[:human genes:d:dolk|DOLK]]|0.547|
|[[:human genes:g:gnb1l|GNB1L]]|0.546|
|[[:human genes:t:ttc4|TTC4]]|0.544|
|[[:human genes:p:pgm3|PGM3]]|0.544|
|[[:human genes:l:lsm11|LSM11]]|0.542|
|[[:human genes:c:csnk2b|CSNK2B]]|0.542|
|[[:human genes:b:bak1|BAK1]]|0.541|
|[[:human genes:p:plaa|PLAA]]|0.539|
|[[:human genes:t:tbca|TBCA]]|0.536|
|[[:human genes:u:ube2g2|UBE2G2]]|0.534|
|[[:human genes:m:mbtps2|MBTPS2]]|0.531|
|[[:human genes:s:slc25a26|SLC25A26]]|0.53|
|[[:human genes:t:taz|TAZ]]|0.53|
|[[:human genes:c:cbfb|CBFB]]|0.529|
|[[:human genes:p:ppa2|PPA2]]|0.528|
|[[:human genes:t:tmem41b|TMEM41B]]|0.527|
|[[:human genes:f:fh|FH]]|0.527|
|[[:human genes:s:sec62|SEC62]]|0.527|
|[[:human genes:b:bap1|BAP1]]|0.524|
|[[:human genes:d:dr1|DR1]]|0.522|
|[[:human genes:t:trmt5|TRMT5]]|0.521|
|[[:human genes:c:chchd4|CHCHD4]]|0.52|
|[[:human genes:d:dpf2|DPF2]]|0.519|
|[[:human genes:t:tsen34|TSEN34]]|0.518|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.517|
|[[:human genes:t:tti2|TTI2]]|0.516|
|[[:human genes:c:cycs|CYCS]]|0.516|
|[[:human genes:r:rpia|RPIA]]|0.515|
|[[:human genes:p:pdap1|PDAP1]]|0.515|
|[[:human genes:t:ten1|TEN1]]|0.514|
|[[:human genes:m:mtor|MTOR]]|0.514|
|[[:human genes:c:crls1|CRLS1]]|0.513|
|[[:human genes:r:rabggtb|RABGGTB]]|0.513|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.51|
|[[:human genes:u:uxt|UXT]]|0.509|
|[[:human genes:u:utp23|UTP23]]|0.509|
|[[:human genes:a:atp5o|ATP5O]]|0.508|
|[[:human genes:p:ppp4c|PPP4C]]|0.508|
|[[:human genes:o:osgep|OSGEP]]|0.507|
|[[:human genes:a:alg6|ALG6]]|0.507|
|[[:human genes:e:eif3f|EIF3F]]|0.505|
|[[:human genes:p:pam16|PAM16]]|0.505|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.505|
|[[:human genes:g:gemin6|GEMIN6]]|0.504|
|[[:human genes:u:urm1|URM1]]|0.504|
|[[:human genes:a:aars|AARS]]|0.504|
|[[:human genes:a:atp5b|ATP5B]]|0.503|
|[[:human genes:p:polr3h|POLR3H]]|0.502|
|[[:human genes:p:ppp6c|PPP6C]]|0.501|
|[[:human genes:v:vrk1|VRK1]]|0.5|
|[[:human genes:n:nsmce1|NSMCE1]]|0.499|
|[[:human genes:a:atp5a1|ATP5A1]]|0.499|
|[[:human genes:t:thoc6|THOC6]]|0.499|
|[[:human genes:l:lsm10|LSM10]]|0.498|
|[[:human genes:m:med16|MED16]]|0.496|
|[[:human genes:c:ccdc101|CCDC101]]|0.495|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.495|
|[[:human genes:f:faf2|FAF2]]|0.494|
|[[:human genes:d:ddx20|DDX20]]|0.494|
|[[:human genes:g:gemin8|GEMIN8]]|0.493|
|[[:human genes:a:atic|ATIC]]|0.493|
|[[:human genes:t:telo2|TELO2]]|0.492|
|[[:human genes:u:ubqln1|UBQLN1]]|0.491|
|[[:human genes:d:dhdds|DHDDS]]|0.491|
|[[:human genes:s:ssb|SSB]]|0.491|
|[[:human genes:n:nsd1|NSD1]]|0.49|
|[[:human genes:r:rpn1|RPN1]]|0.489|
|[[:human genes:c:ctc1|CTC1]]|0.489|
|[[:human genes:e:elac2|ELAC2]]|0.489|
|[[:human genes:b:bcs1l|BCS1L]]|0.489|
|[[:human genes:t:tbcb|TBCB]]|0.488|
|[[:human genes:h:haus8|HAUS8]]|0.488|
|[[:human genes:g:gemin7|GEMIN7]]|0.486|
|[[:human genes:t:txnl4b|TXNL4B]]|0.485|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.483|
|[[:human genes:a:atp2a2|ATP2A2]]|0.483|
|[[:human genes:u:uba3|UBA3]]|0.481|
|[[:human genes:d:dad1|DAD1]]|0.479|
|[[:human genes:g:gtf3a|GTF3A]]|0.479|
|[[:human genes:n:nars|NARS]]|0.479|
|[[:human genes:o:otud5|OTUD5]]|0.478|
|[[:human genes:k:kdsr|KDSR]]|0.477|
|[[:human genes:c:cep57|CEP57]]|0.477|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.477|
|[[:human genes:d:ddx1|DDX1]]|0.476|
|[[:human genes:s:srd5a3|SRD5A3]]|0.476|
|[[:human genes:r:rft1|RFT1]]|0.476|
|[[:human genes:y:yars|YARS]]|0.475|
|[[:human genes:t:timm13|TIMM13]]|0.471|
|[[:human genes:o:oip5|OIP5]]|0.471|
|[[:human genes:u:ube2k|UBE2K]]|0.47|
|[[:human genes:c:cct7|CCT7]]|0.47|
|[[:human genes:v:vdac2|VDAC2]]|0.469|
|[[:human genes:t:tti1|TTI1]]|0.468|
|[[:human genes:e:elp2|ELP2]]|0.468|
|[[:human genes:a:alg14|ALG14]]|0.467|
|[[:human genes:t:tprkb|TPRKB]]|0.465|
|[[:human genes:c:cept1|CEPT1]]|0.465|
|[[:human genes:l:lamtor5|LAMTOR5]]|0.464|
|[[:human genes:w:wdr59|WDR59]]|0.463|
|[[:human genes:u:uqcr10|UQCR10]]|0.463|
|[[:human genes:f:fnta|FNTA]]|0.462|
|[[:human genes:d:dnlz|DNLZ]]|0.462|
|[[:human genes:s:sars2|SARS2]]|0.461|
|[[:human genes:p:pik3r4|PIK3R4]]|0.461|
|[[:human genes:m:mars|MARS]]|0.46|
|[[:human genes:s:slc25a19|SLC25A19]]|0.46|
|[[:human genes:m:med4|MED4]]|0.459|
|[[:human genes:s:sec61g|SEC61G]]|0.458|
|[[:human genes:d:ddx55|DDX55]]|0.457|
|[[:human genes:a:atp5d|ATP5D]]|0.456|
|[[:human genes:r:rbm14|RBM14]]|0.456|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.454|
|[[:human genes:p:pggt1b|PGGT1B]]|0.453|
|[[:human genes:e:elp3|ELP3]]|0.453|
|[[:human genes:u:uba5|UBA5]]|0.453|
|[[:human genes:t:trmt10a|TRMT10A]]|0.452|
|[[:human genes:g:gemin5|GEMIN5]]|0.452|
|[[:human genes:m:meaf6|MEAF6]]|0.451|
|[[:human genes:t:tpi1|TPI1]]|0.451|
|[[:human genes:c:chordc1|CHORDC1]]|0.451|
|[[:human genes:e:eprs|EPRS]]|0.45|
|[[:human genes:s:sec63|SEC63]]|0.45|
|[[:human genes:m:march5|MARCH5]]|0.45|
|[[:human genes:v:vhl|VHL]]|0.449|
|[[:human genes:r:rad1|RAD1]]|0.449|
|[[:human genes:s:sec16a|SEC16A]]|0.449|
|[[:human genes:c:cdipt|CDIPT]]|0.448|
|[[:human genes:t:tgs1|TGS1]]|0.447|
|[[:human genes:p:pyroxd1|PYROXD1]]|0.446|
|[[:human genes:d:ddost|DDOST]]|0.446|
|[[:human genes:m:mrpl21|MRPL21]]|0.446|
|[[:human genes:t:tmed10|TMED10]]|0.446|
|[[:human genes:p:pisd|PISD]]|0.446|
|[[:human genes:m:mrps14|MRPS14]]|0.444|
|[[:human genes:m:mllt1|MLLT1]]|0.444|
|[[:human genes:e:eno1|ENO1]]|0.444|
|[[:human genes:t:tbp|TBP]]|0.443|
|[[:human genes:t:trmt61a|TRMT61A]]|0.442|
|[[:human genes:y:yars2|YARS2]]|0.441|
|[[:human genes:t:tmem242|TMEM242]]|0.441|
|[[:human genes:s:serf2|SERF2]]|0.441|
|[[:human genes:w:wdr24|WDR24]]|0.441|
|[[:human genes:c:c15orf41|C15orf41]]|0.441|
|[[:human genes:t:tufm|TUFM]]|0.44|
|[[:human genes:z:znhit1|ZNHIT1]]|0.439|
|[[:human genes:n:nxt1|NXT1]]|0.437|
|[[:human genes:o:opa1|OPA1]]|0.437|
|[[:human genes:b:bub3|BUB3]]|0.436|
|[[:human genes:p:polr3b|POLR3B]]|0.435|
|[[:human genes:s:slc35b1|SLC35B1]]|0.435|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.434|
|[[:human genes:u:uso1|USO1]]|0.434|
|[[:human genes:m:mrps2|MRPS2]]|0.433|
|[[:human genes:w:wdr1|WDR1]]|0.432|
|[[:human genes:c:c11orf57|C11orf57]]|0.432|
|[[:human genes:t:tkt|TKT]]|0.432|
|[[:human genes:d:dnajc3|DNAJC3]]|0.431|
|[[:human genes:k:kdm8|KDM8]]|0.431|
|[[:human genes:s:spcs3|SPCS3]]|0.431|
|[[:human genes:d:dhx29|DHX29]]|0.43|
|[[:human genes:m:mfn1|MFN1]]|0.43|
|[[:human genes:v:vmp1|VMP1]]|0.429|
|[[:human genes:t:txnrd1|TXNRD1]]|0.428|
|[[:human genes:e:eef1e1|EEF1E1]]|0.427|
|[[:human genes:s:srp68|SRP68]]|0.426|
|[[:human genes:d:diablo|DIABLO]]|0.425|
|[[:human genes:s:snapc5|SNAPC5]]|0.425|
|[[:human genes:u:uqcrq|UQCRQ]]|0.424|
|[[:human genes:e:elf2|ELF2]]|0.424|
|[[:human genes:m:mrps34|MRPS34]]|0.423|
|[[:human genes:s:sdha|SDHA]]|0.423|
|[[:human genes:m:msto1|MSTO1]]|0.423|
|[[:human genes:c:crcp|CRCP]]|0.422|
|[[:human genes:p:ptdss1|PTDSS1]]|0.422|
|[[:human genes:n:n6amt1|N6AMT1]]|0.421|
|[[:human genes:n:nbn|NBN]]|0.421|
|[[:human genes:t:trim28|TRIM28]]|0.419|
|[[:human genes:w:wdr82|WDR82]]|0.419|
|[[:human genes:t:tp53|TP53]]|0.419|
|[[:human genes:m:mrps6|MRPS6]]|0.418|
|[[:human genes:t:tomm40|TOMM40]]|0.418|
|[[:human genes:e:exoc3|EXOC3]]|0.417|
|[[:human genes:c:cmtr1|CMTR1]]|0.417|
|[[:human genes:s:srp72|SRP72]]|0.416|
|[[:human genes:s:srprb|SRPRB]]|0.416|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.415|
|[[:human genes:m:mrpl23|MRPL23]]|0.415|
|[[:human genes:i:irf2bp2|IRF2BP2]]|0.415|
|[[:human genes:s:snf8|SNF8]]|0.412|
|[[:human genes:f:fntb|FNTB]]|0.411|
|[[:human genes:c:c17orf89|C17orf89]]|0.411|
|[[:human genes:m:mrps18a|MRPS18A]]|0.41|
|[[:human genes:s:sco2|SCO2]]|0.41|
|[[:human genes:m:med23|MED23]]|0.41|
|[[:human genes:u:ube2m|UBE2M]]|0.41|
|[[:human genes:r:rfk|RFK]]|0.409|
|[[:human genes:a:alg8|ALG8]]|0.408|
|[[:human genes:c:cox16|COX16]]|0.408|
|[[:human genes:s:stt3a|STT3A]]|0.408|
|[[:human genes:s:spcs2|SPCS2]]|0.408|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.408|
|[[:human genes:z:zrsr2|ZRSR2]]|0.406|
|[[:human genes:i:id3|ID3]]|0.406|
|[[:human genes:d:ddx39a|DDX39A]]|0.406|
|[[:human genes:n:nhlrc2|NHLRC2]]|0.405|
|[[:human genes:p:pdcd6ip|PDCD6IP]]|0.405|
|[[:human genes:d:dars2|DARS2]]|0.404|
|[[:human genes:t:timm22|TIMM22]]|0.404|
|[[:human genes:b:brwd1|BRWD1]]|0.404|
|[[:human genes:c:c14orf80|C14orf80]]|0.404|
|[[:human genes:o:obfc1|OBFC1]]|0.403|
|[[:human genes:d:dap3|DAP3]]|0.403|
|[[:human genes:c:c14orf166|C14orf166]]|0.403|
|[[:human genes:t:tsen2|TSEN2]]|0.402|
|[[:human genes:a:atp5i|ATP5I]]|0.402|
|[[:human genes:t:tpk1|TPK1]]|0.4|
|[[:human genes:c:cars|CARS]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 22/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|1/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|2/20|
|lung|2/75|
|lymphocyte|0/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1757
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.09 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UAP1 Expression in NALM6 Cells: 5.09'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>