======= UBAP1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBAP1
  * **<color #00a2e8>Official Name</color>**: ubiquitin associated protein 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51271|51271]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NZ09|Q9NZ09]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBAP1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBAP1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609787|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ESCRT I complex|
|ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway|
|intracellular transport of virus|
|host cell|
|transport of virus|
|multi-organism transport|
|multi-organism localization|
|ubiquitin binding|
|viral life cycle|
|endosome membrane|
|endosomal transport|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|viral process|
|symbiotic process|
|interspecies interaction between organisms|
|cellular macromolecule catabolic process|
|Golgi apparatus|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|establishment of protein localization|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp521|Salinomycin 3.5μM R08 exp521]]|-2.88|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-2.25|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|-1.96|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|-1.83|
|[[:results:exp356|Docosahexaenoic-acid 50μM R07 exp356]]|-1.79|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.79|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.72|
|[[:results:exp278|CVT-10216 0.1μM R06 exp278]]|1.83|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.96|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.97|
|[[:results:exp18|Doxycycline 10μM R00 exp18]]|2.08|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|2.1|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.29|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.8|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tfip11|TFIP11]]|0.517|
|[[:human genes:p:psmd11|PSMD11]]|0.502|
|[[:human genes:s:syt9|SYT9]]|0.483|
|[[:human genes:s:supt6h|SUPT6H]]|0.48|
|[[:human genes:r:rbm39|RBM39]]|0.48|
|[[:human genes:a:akirin2|AKIRIN2]]|0.474|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.47|
|[[:human genes:a:atxn1|ATXN1]]|0.464|
|[[:human genes:m:myh2|MYH2]]|0.462|
|[[:human genes:m:mt1e|MT1E]]|0.461|
|[[:human genes:k:kctd17|KCTD17]]|0.459|
|[[:human genes:c:copg1|COPG1]]|0.454|
|[[:human genes:t:terf2|TERF2]]|0.451|
|[[:human genes:v:vasn|VASN]]|0.451|
|[[:human genes:o:orc6|ORC6]]|0.444|
|[[:human genes:c:chd4|CHD4]]|0.441|
|[[:human genes:c:cbwd3|CBWD3]]|0.434|
|[[:human genes:p:psmd3|PSMD3]]|0.433|
|[[:human genes:d:dnttip2|DNTTIP2]]|0.431|
|[[:human genes:t:ticrr|TICRR]]|0.43|
|[[:human genes:a:aqr|AQR]]|0.43|
|[[:human genes:g:gid4|GID4]]|0.43|
|[[:human genes:a:acsf2|ACSF2]]|0.429|
|[[:human genes:o:or10g3|OR10G3]]|0.428|
|[[:human genes:r:ranbp2|RANBP2]]|0.427|
|[[:human genes:o:orc1|ORC1]]|0.426|
|[[:human genes:g:gar1|GAR1]]|0.424|
|[[:human genes:s:scaf1|SCAF1]]|0.424|
|[[:human genes:c:c14orf93|C14orf93]]|0.422|
|[[:human genes:t:tspy8|TSPY8]]|0.422|
|[[:human genes:t:thoc1|THOC1]]|0.421|
|[[:human genes:c:cdca3|CDCA3]]|0.42|
|[[:human genes:s:sf3a3|SF3A3]]|0.42|
|[[:human genes:m:med12|MED12]]|0.42|
|[[:human genes:m:myo1h|MYO1H]]|0.419|
|[[:human genes:c:cdc6|CDC6]]|0.417|
|[[:human genes:z:znf106|ZNF106]]|0.417|
|[[:human genes:s:supt5h|SUPT5H]]|0.416|
|[[:human genes:p:psmc1|PSMC1]]|0.416|
|[[:human genes:a:arcn1|ARCN1]]|0.416|
|[[:human genes:z:znf830|ZNF830]]|0.414|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.414|
|[[:human genes:v:vps54|VPS54]]|0.414|
|[[:human genes:p:plk4|PLK4]]|0.412|
|[[:human genes:c:cbwd5|CBWD5]]|0.411|
|[[:human genes:c:ciapin1|CIAPIN1]]|0.41|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.409|
|[[:human genes:a:ankle1|ANKLE1]]|0.407|
|[[:human genes:s:slc4a1|SLC4A1]]|0.407|
|[[:human genes:e:exosc5|EXOSC5]]|0.406|
|[[:human genes:c:cdc73|CDC73]]|0.406|
|[[:human genes:s:smg7|SMG7]]|0.405|
|[[:human genes:c:cbwd6|CBWD6]]|0.405|
|[[:human genes:u:usp36|USP36]]|0.405|
|[[:human genes:c:copz1|COPZ1]]|0.404|
|[[:human genes:h:hist1h2be|HIST1H2BE]]|0.404|
|[[:human genes:c:chmp2a|CHMP2A]]|0.402|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.402|
|[[:human genes:c:copa|COPA]]|0.402|
|[[:human genes:n:napa|NAPA]]|0.402|
|[[:human genes:l:loc643669|LOC643669]]|0.402|
|[[:human genes:p:psmd7|PSMD7]]|0.4|
|[[:human genes:h:hap1|HAP1]]|0.4|
|[[:human genes:r:rps12|RPS12]]|0.4|
|[[:human genes:d:dtl|DTL]]|0.4|
|[[:human genes:a:ankle2|ANKLE2]]|0.4|
|[[:human genes:h:hgc6.3|HGC6.3]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 191/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|9/28|
|blood|13/28|
|bone|5/26|
|breast|11/33|
|central nervous system|6/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|2/13|
|fibroblast|0/1|
|gastric|7/16|
|kidney|5/21|
|liver|3/20|
|lung|25/75|
|lymphocyte|9/16|
|ovary|8/26|
|pancreas|5/24|
|peripheral nervous system|1/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|1/2|
|upper aerodigestive|5/22|
|urinary tract|10/29|
|uterus|2/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1597
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBAP1 Expression in NALM6 Cells: 5.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>