======= UBC =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBC
  * **<color #00a2e8>Official Name</color>**: ubiquitin C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7316|7316]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P0CG48|P0CG48]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBC&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBC|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191340|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene represents a ubiquitin gene, ubiquitin C. The encoded protein is a polyubiquitin precursor. Conjugation of ubiquitin monomers or polymers can lead to various effects within a cell, depending on the residues to which ubiquitin is conjugated. Ubiquitination has been associated with protein degradation, DNA repair, cell cycle regulation, kinase modification, endocytosis, and regulation of other cell signaling pathways. [provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Rad60-SLD|
|ubiquitin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein tag|
|error-prone translesion synthesis|
|error-free translesion synthesis|
|nucleotide-excision repair, DNA duplex unwinding|
|nucleotide-excision repair, DNA damage recognition|
|nucleotide-excision repair, DNA gap filling|
|global genome nucleotide-excision repair|
|nucleotide-binding oligomerization domain containing signaling pathway|
|nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway|
|TRIF-dependent toll-like receptor signaling pathway|
|nucleotide-excision repair, preincision complex assembly|
|MyD88-dependent toll-like receptor signaling pathway|
|MyD88-independent toll-like receptor signaling pathway|
|cytoplasmic pattern recognition receptor signaling pathway|
|nucleotide-excision repair, DNA incision, 5-to lesion|
|virion assembly|
|DNA damage response, detection of DNA damage|
|nucleotide-excision repair, DNA incision|
|translesion synthesis|
|DNA synthesis involved in DNA repair|
|interstrand cross-link repair|
|postreplication repair|
|intracellular transport of virus|
|host cell|
|transport of virus|
|endocytic vesicle membrane|
|establishment of protein localization to peroxisome|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|I-kappaB kinase/NF-kappaB signaling|
|peroxisomal transport|
|multi-organism localization|
|multi-organism transport|
|transcription-coupled nucleotide-excision repair|
|negative regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of cellular response to transforming growth factor beta stimulus|
|regulation of transcription from RNA polymerase II promoter in response to hypoxia|
|peroxisome organization|
|JNK cascade|
|anaphase-promoting complex-dependent catabolic process|
|interleukin-1-mediated signaling pathway|
|toll-like receptor signaling pathway|
|transforming growth factor beta receptor signaling pathway|
|protease binding|
|stress-activated MAPK cascade|
|DNA biosynthetic process|
|nucleotide-excision repair|
|DNA duplex unwinding|
|regulation of transforming growth factor beta receptor signaling pathway|
|negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|regulation of cellular response to transforming growth factor beta stimulus|
|DNA geometric change|
|regulation of transcription from RNA polymerase II promoter in response to stress|
|regulation of DNA-templated transcription in response to stress|
|pattern recognition receptor signaling pathway|
|vesicle|
|stress-activated protein kinase signaling cascade|
|negative regulation of cellular response to growth factor stimulus|
|positive regulation of NF-kappaB transcription factor activity|
|cellular response to transforming growth factor beta stimulus|
|activation of MAPK activity|
|response to transforming growth factor beta|
|mitochondrial outer membrane|
|intracellular receptor signaling pathway|
|cellular response to interleukin-1|
|regulation of mRNA stability|
|regulation of RNA stability|
|cellular response to hypoxia|
|cellular response to decreased oxygen levels|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|response to interleukin-1|
|regulation of mRNA catabolic process|
|viral life cycle|
|protein-DNA complex assembly|
|endosome membrane|
|cellular response to oxygen levels|
|endosomal transport|
|innate immune response-activating signal transduction|
|regulation of transmembrane receptor protein serine/threonine kinase signaling pathway|
|protein-DNA complex subunit organization|
|activation of innate immune response|
|positive regulation of DNA-binding transcription factor activity|
|positive regulation of MAP kinase activity|
|regulation of cellular response to growth factor stimulus|
|protein deubiquitination|
|ubiquitin protein ligase binding|
|DNA conformation change|
|protein modification by small protein removal|
|protein polyubiquitination|
|nucleic acid phosphodiester bond hydrolysis|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|activation of protein kinase activity|
|regulation of mRNA metabolic process|
|positive regulation of protein serine/threonine kinase activity|
|positive regulation of innate immune response|
|regulation of MAP kinase activity|
|response to hypoxia|
|proteasomal protein catabolic process|
|protein targeting|
|Wnt signaling pathway|
|response to decreased oxygen levels|
|cell-cell signaling by wnt|
|positive regulation of response to biotic stimulus|
|MAPK cascade|
|response to oxygen levels|
|signal transduction by protein phosphorylation|
|regulation of DNA-binding transcription factor activity|
|cell surface receptor signaling pathway involved in cell-cell signaling|
|establishment of protein localization to organelle|
|regulation of innate immune response|
|positive regulation of defense response|
|cellular response to growth factor stimulus|
|positive regulation of multi-organism process|
|DNA repair|
|regulation of protein serine/threonine kinase activity|
|regulation of response to biotic stimulus|
|posttranscriptional regulation of gene expression|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|positive regulation of protein kinase activity|
|positive regulation of MAPK cascade|
|modification-dependent macromolecule catabolic process|
|immune response-activating signal transduction|
|positive regulation of kinase activity|
|proteolysis involved in cellular protein catabolic process|
|immune response-regulating signaling pathway|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|positive regulation of transferase activity|
|cytokine-mediated signaling pathway|
|protein catabolic process|
|protein ubiquitination|
|detection of stimulus|
|positive regulation of cell death|
|viral process|
|enzyme linked receptor protein signaling pathway|
|protein localization to organelle|
|DNA metabolic process|
|regulation of MAPK cascade|
|regulation of defense response|
|protein modification by small protein conjugation|
|cellular response to DNA damage stimulus|
|regulation of multi-organism process|
|symbiotic process|
|regulation of protein kinase activity|
|interspecies interaction between organisms|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|membrane organization|
|negative regulation of transcription by RNA polymerase II|
|positive regulation of immune response|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|protein phosphorylation|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|intracellular protein transport|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|chromosome organization|
|regulation of response to external stimulus|
|nucleobase-containing compound biosynthetic process|
|response to cytokine|
|cell-cell signaling|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|response to abiotic stimulus|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|transmembrane transport|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of protein phosphorylation|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|regulation of response to stress|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|peptide transport|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|protein-containing complex assembly|
|regulation of programmed cell death|
|amide transport|
|cellular protein localization|
|regulation of phosphorylation|
|extracellular space|
|cellular macromolecule localization|
|positive regulation of cellular protein metabolic process|
|establishment of protein localization|
|negative regulation of response to stimulus|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|regulation of cell death|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|establishment of localization in cell|
|regulation of protein modification process|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|vesicle-mediated transport|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.45|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2h|UBE2H]]|0.408|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 489/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|1/1|
|bile duct|19/28|
|blood|16/28|
|bone|19/26|
|breast|29/33|
|central nervous system|40/56|
|cervix|2/4|
|colorectal|9/17|
|esophagus|6/13|
|fibroblast|0/1|
|gastric|9/16|
|kidney|12/21|
|liver|10/20|
|lung|45/75|
|lymphocyte|9/16|
|ovary|19/26|
|pancreas|14/24|
|peripheral nervous system|9/16|
|plasma cell|7/15|
|prostate|1/1|
|skin|22/24|
|soft tissue|6/9|
|thyroid|2/2|
|upper aerodigestive|14/22|
|urinary tract|18/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7198
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 9.35 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBC Expression in NALM6 Cells: 9.35'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>