======= UBE2H =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2H
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 H
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7328|7328]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P62256|P62256]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2H&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2H|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601082|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'- and 'Lys-48'-linked polyubiquitination. Capable, in vitro, to ubiquitinate histone H2A. {ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:8132613}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|protein K11-linked ubiquitination|
|ubiquitin conjugating enzyme activity|
|protein K48-linked ubiquitination|
|ubiquitin-protein transferase activity|
|protein polyubiquitination|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|ATP binding|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-5.61|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|-3.6|
|[[:results:exp382|Palbociclib 1μM R07 exp382]]|-3.48|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|-3.37|
|[[:results:exp359|FK-506 30μM R07 exp359]]|-3.17|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.74|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-2.51|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-2.25|
|[[:results:exp435|JQ1 0.8μM R08 exp435]]|-2.19|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.11|
|[[:results:exp78|Pterostilbene 16μM R02 exp78]]|-2.11|
|[[:results:exp227|Cryptotanshinone 12μM R05 exp227]]|-2.08|
|[[:results:exp517|Quercetin 20μM R08 exp517]]|-2.05|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.04|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.02|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|-1.93|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|-1.88|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.88|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.87|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.75|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|-1.73|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.71|
|[[:results:exp389|PF-06409577 20μM R07 exp389]]|1.71|
|[[:results:exp392|PT-1 25μM R07 exp392]]|1.71|
|[[:results:exp124|GSK343 3μM R03 exp124]]|1.72|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|1.78|
|[[:results:exp433|LJH685 50μM R08 exp433]]|1.78|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.79|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.81|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|1.87|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.9|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|1.97|
|[[:results:exp242|Radicicol 0.16μM R05 exp242]]|2|
|[[:results:exp307|Rapamycin 2μM plus Cyclosporin-A 3μM R07 exp307]]|2.09|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.14|
|[[:results:exp360|Genistein 15μM R07 exp360]]|2.19|
|[[:results:exp70|INK128 0.2μM R02 exp70]]|2.2|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|2.2|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|2.38|
|[[:results:exp134|MS023 2μM R03 exp134]]|2.45|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|2.46|
|[[:results:exp308|Rapamycin 2μM plus FK-506 5μM R07 exp308]]|2.46|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|2.72|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.81|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|2.86|
|[[:results:exp282|Fluvastatin 2.2μM R06 exp282]]|2.88|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|2.89|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.07|
|[[:results:exp229|Dimethyloxaloylglycine 100μM R05 exp229]]|3.23|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.31|
|[[:results:exp429|Rapamycin 0.001μM R08 exp429]]|4.01|
|[[:results:exp116|AICAR 240μM R03 exp116]]|4.42|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|4.5|
|[[:results:exp29|Rapamycin 1μM R00 exp29]]|4.64|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|5.73|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|5.95|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:maea|MAEA]]|0.805|
|[[:human genes:y:ypel5|YPEL5]]|0.792|
|[[:human genes:w:wdr26|WDR26]]|0.765|
|[[:human genes:g:gid8|GID8]]|0.733|
|[[:human genes:m:memo1|MEMO1]]|0.58|
|[[:human genes:r:rmnd5a|RMND5A]]|0.543|
|[[:human genes:c:cnot8|CNOT8]]|0.487|
|[[:human genes:o:otub1|OTUB1]]|0.464|
|[[:human genes:c:cdk8|CDK8]]|0.455|
|[[:human genes:r:ranbp9|RANBP9]]|0.444|
|[[:human genes:a:anp32a|ANP32A]]|0.428|
|[[:human genes:k:kdm6a|KDM6A]]|0.411|
|[[:human genes:u:ubc|UBC]]|0.408|
|[[:human genes:f:fkbp1a|FKBP1A]]|0.407|
|[[:human genes:d:dazap1|DAZAP1]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 43/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|0/28|
|bone|2/26|
|breast|5/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|0/21|
|liver|0/20|
|lung|7/75|
|lymphocyte|1/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|1/16|
|plasma cell|2/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|4/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14084
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.11 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2H Expression in NALM6 Cells: 5.11'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>