======= UBE2I =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2I
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 I
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7329|7329]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P63279|P63279]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2I&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2I|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601661|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts the ubiquitin-like proteins SUMO1, SUMO2, SUMO3 and SUMO4 from the UBLE1A-UBLE1B E1 complex and catalyzes their covalent attachment to other proteins with the help of an E3 ligase such as RANBP2, CBX4 and ZNF451. Can catalyze the formation of poly-SUMO chains. Necessary for sumoylation of FOXL2 and KAT5. Essential for nuclear architecture and chromosome segregation. Sumoylates p53/TP53 at 'Lys-386'. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:15809060, ECO:0000269|PubMed:17466333, ECO:0000269|PubMed:19638400, ECO:0000269|PubMed:19744555, ECO:0000269|PubMed:20077568, ECO:0000269|PubMed:26524494, ECO:0000269|PubMed:8668529}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of SUMO transferase activity|
|sumoylated E2 ligase complex|
|SUMO conjugating enzyme activity|
|regulation of SUMO transferase activity|
|HLH domain binding|
|transferase complex|
|RING-like zinc finger domain binding|
|small protein activating enzyme binding|
|positive regulation of protein sumoylation|
|SUMO transferase activity|
|regulation of protein sumoylation|
|synaptonemal complex|
|protein sumoylation|
|PML body|
|positive regulation of protein modification by small protein conjugation or removal|
|nuclear envelope|
|positive regulation of I-kappaB kinase/NF-kappaB signaling|
|regulation of protein modification by small protein conjugation or removal|
|regulation of I-kappaB kinase/NF-kappaB signaling|
|chromosome segregation|
|peptidyl-lysine modification|
|transcription factor binding|
|enzyme binding|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of transferase activity|
|protein catabolic process|
|viral process|
|protein modification by small protein conjugation|
|symbiotic process|
|interspecies interaction between organisms|
|negative regulation of transcription by RNA polymerase II|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|positive regulation of intracellular signal transduction|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of transcription, DNA-templated|
|positive regulation of protein modification process|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|RNA binding|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|ATP binding|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|positive regulation of cellular protein metabolic process|
|positive regulation of signal transduction|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-3.37|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-2.34|
|[[:results:exp312|2-Methoxyestradiol 0.55 to 1μM on day4 R07 exp312]]|-2.29|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|-2.16|
|[[:results:exp376|Losmapimod 1μM R07 exp376]]|-2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.84|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|-1.76|
|[[:results:exp67|BVD-523 15μM R02 exp67]]|-1.74|
|[[:results:exp437|Ethanol 0.003 R08 exp437]]|1.74|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|1.78|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|1.97|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|1.98|
|[[:results:exp477|DKK1 89ng/ml R08 exp477]]|2.33|
|[[:results:exp299|Talazoparib 0.006μM R06 exp299]]|2.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 461/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|0/1|
|bile duct|23/28|
|blood|15/28|
|bone|21/25|
|breast|20/33|
|central nervous system|37/56|
|cervix|4/4|
|colorectal|11/17|
|esophagus|3/13|
|fibroblast|1/1|
|gastric|9/15|
|kidney|14/21|
|liver|12/20|
|lung|51/75|
|lymphocyte|6/14|
|ovary|20/26|
|pancreas|15/24|
|peripheral nervous system|12/16|
|plasma cell|6/15|
|prostate|1/1|
|skin|18/24|
|soft tissue|5/7|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|16/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 406
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.43 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2I Expression in NALM6 Cells: 7.43'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>