======= UBE2K =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2K
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 K
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=3093|3093]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P61086|P61086]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2K&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2K|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/602846|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UBA|
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|free ubiquitin chain polymerization|
|ubiquitin recycling|
|positive regulation of type I interferon-mediated signaling pathway|
|ubiquitin-ubiquitin ligase activity|
|filopodium tip|
|cellular response to interferon-beta|
|response to interferon-beta|
|positive regulation of peptidyl-threonine phosphorylation|
|intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress|
|regulation of type I interferon-mediated signaling pathway|
|ubiquitin conjugating enzyme activity|
|regulation of peptidyl-threonine phosphorylation|
|positive regulation of cytokine-mediated signaling pathway|
|protein K48-linked ubiquitination|
|positive regulation of response to cytokine stimulus|
|protein polymerization|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|intrinsic apoptotic signaling pathway|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of cytokine-mediated signaling pathway|
|regulation of response to cytokine stimulus|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|ubiquitin-protein transferase activity|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|apoptotic signaling pathway|
|ubiquitin protein ligase binding|
|protein polyubiquitination|
|positive regulation of innate immune response|
|positive regulation of response to biotic stimulus|
|regulation of protein catabolic process|
|regulation of innate immune response|
|positive regulation of defense response|
|positive regulation of multi-organism process|
|regulation of response to biotic stimulus|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|positive regulation of response to external stimulus|
|cellular protein catabolic process|
|protein catabolic process|
|protein ubiquitination|
|regulation of proteolysis|
|regulation of defense response|
|protein modification by small protein conjugation|
|regulation of multi-organism process|
|regulation of cellular catabolic process|
|cellular protein-containing complex assembly|
|positive regulation of immune response|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|apoptotic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cellular response to cytokine stimulus|
|positive regulation of protein phosphorylation|
|macromolecule catabolic process|
|programmed cell death|
|positive regulation of phosphorylation|
|organonitrogen compound catabolic process|
|cell death|
|regulation of response to external stimulus|
|response to cytokine|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|positive regulation of protein modification process|
|proteolysis|
|regulation of protein phosphorylation|
|regulation of response to stress|
|ATP binding|
|protein-containing complex assembly|
|regulation of phosphorylation|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|regulation of immune system process|
|positive regulation of signal transduction|
|intracellular signal transduction|
|cellular response to stress|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|cellular catabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|-3.07|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.88|
|[[:results:exp47|Lapatinib 5μM R01 exp47]]|-1.79|
|[[:results:exp520|Rucaparib 6.5μM R08 exp520]]|-1.77|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|1.85|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.93|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|2.02|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|2.07|
|[[:results:exp34|Rotenone 20μM R00 exp34]]|2.11|
|[[:results:exp355|Dinaciclib 0.007μM R07 exp355]]|2.15|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|2.17|
|[[:results:exp199|Etoposide 0.3μM R05 exp199]]|2.19|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.22|
|[[:results:exp93|DABN racemic mixture R03 exp93]]|2.23|
|[[:results:exp256|HMS-I1 10μM R06 exp256]]|2.34|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.36|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.36|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|2.39|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|2.51|
|[[:results:exp33|Rotenone 2μM R00 exp33]]|2.53|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|2.68|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.68|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|2.69|
|[[:results:exp354|Diepoxybutane 3μM R07 exp354]]|2.82|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.95|
|[[:results:exp28|Pimelic-diphenylamide-106 5μM R00 exp28]]|2.99|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|3|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|3.13|
|[[:results:exp2|5-Fluorouracil 20μM R00 exp2]]|4.01|
|[[:results:exp3|Actinomycin-D 0.001μM R00 exp3]]|4.79|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.635|
|[[:human genes:g:gfpt1|GFPT1]]|0.581|
|[[:human genes:p:plaa|PLAA]]|0.577|
|[[:human genes:b:bap1|BAP1]]|0.52|
|[[:human genes:m:mfn1|MFN1]]|0.52|
|[[:human genes:d:dohh|DOHH]]|0.519|
|[[:human genes:n:nxt1|NXT1]]|0.516|
|[[:human genes:c:casp9|CASP9]]|0.513|
|[[:human genes:e:eny2|ENY2]]|0.51|
|[[:human genes:a:apaf1|APAF1]]|0.504|
|[[:human genes:r:rptor|RPTOR]]|0.502|
|[[:human genes:c:ctdnep1|CTDNEP1]]|0.499|
|[[:human genes:h:hspd1|HSPD1]]|0.495|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.493|
|[[:human genes:t:triap1|TRIAP1]]|0.481|
|[[:human genes:m:meaf6|MEAF6]]|0.479|
|[[:human genes:p:pmm2|PMM2]]|0.477|
|[[:human genes:h:hccs|HCCS]]|0.476|
|[[:human genes:c:csnk2b|CSNK2B]]|0.473|
|[[:human genes:a:alg5|ALG5]]|0.473|
|[[:human genes:u:uap1|UAP1]]|0.47|
|[[:human genes:t:thg1l|THG1L]]|0.467|
|[[:human genes:r:rnmt|RNMT]]|0.458|
|[[:human genes:g:gabpa|GABPA]]|0.455|
|[[:human genes:r:rtcb|RTCB]]|0.455|
|[[:human genes:r:rad23b|RAD23B]]|0.455|
|[[:human genes:u:ubqln1|UBQLN1]]|0.453|
|[[:human genes:d:dpagt1|DPAGT1]]|0.448|
|[[:human genes:n:nae1|NAE1]]|0.447|
|[[:human genes:d:diablo|DIABLO]]|0.445|
|[[:human genes:n:nsmce1|NSMCE1]]|0.442|
|[[:human genes:c:cycs|CYCS]]|0.442|
|[[:human genes:a:alg1|ALG1]]|0.441|
|[[:human genes:u:ube2j1|UBE2J1]]|0.441|
|[[:human genes:f:faf2|FAF2]]|0.436|
|[[:human genes:u:ube2g2|UBE2G2]]|0.432|
|[[:human genes:t:tmed10|TMED10]]|0.432|
|[[:human genes:s:slc25a26|SLC25A26]]|0.432|
|[[:human genes:v:vmp1|VMP1]]|0.43|
|[[:human genes:c:crls1|CRLS1]]|0.427|
|[[:human genes:f:fgfr1op|FGFR1OP]]|0.427|
|[[:human genes:n:nsd1|NSD1]]|0.425|
|[[:human genes:g:gmppb|GMPPB]]|0.424|
|[[:human genes:g:gtf3a|GTF3A]]|0.423|
|[[:human genes:t:trmt5|TRMT5]]|0.419|
|[[:human genes:s:suv420h1|SUV420H1]]|0.418|
|[[:human genes:a:atp5j|ATP5J]]|0.417|
|[[:human genes:i:id3|ID3]]|0.416|
|[[:human genes:p:ppa2|PPA2]]|0.414|
|[[:human genes:d:dhps|DHPS]]|0.413|
|[[:human genes:s:srp72|SRP72]]|0.411|
|[[:human genes:s:srp14|SRP14]]|0.404|
|[[:human genes:b:bak1|BAK1]]|0.4|
|[[:human genes:m:mtor|MTOR]]|0.4|
|[[:human genes:r:rpe|RPE]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|1/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5908
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.82 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2K Expression in NALM6 Cells: 6.82'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>