======= UBE2S =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE2S
  * **<color #00a2e8>Official Name</color>**: ubiquitin conjugating enzyme E2 S
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27338|27338]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q16763|Q16763]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE2S&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE2S|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/610309|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins (PubMed:22496338). Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle- regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit (PubMed:19820702, PubMed:19822757, PubMed:27259151). Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as an E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A (PubMed:16819549). In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination (PubMed:20061386, PubMed:20622874). {ECO:0000269|PubMed:16819549, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386, ECO:0000269|PubMed:20622874, ECO:0000269|PubMed:22496338, ECO:0000269|PubMed:27259151}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UQ con|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|free ubiquitin chain polymerization|
|protein K27-linked ubiquitination|
|protein K29-linked ubiquitination|
|ubiquitin recycling|
|protein K6-linked ubiquitination|
|anaphase-promoting complex binding|
|positive regulation of ubiquitin protein ligase activity|
|exit from mitosis|
|anaphase-promoting complex|
|regulation of ubiquitin protein ligase activity|
|protein K11-linked ubiquitination|
|positive regulation of ubiquitin-protein transferase activity|
|protein K63-linked ubiquitination|
|ubiquitin conjugating enzyme activity|
|regulation of ubiquitin-protein transferase activity|
|anaphase-promoting complex-dependent catabolic process|
|protein polymerization|
|positive regulation of protein ubiquitination|
|positive regulation of protein modification by small protein conjugation or removal|
|mitotic nuclear division|
|regulation of protein ubiquitination|
|regulation of protein modification by small protein conjugation or removal|
|ubiquitin-protein transferase activity|
|mitotic cell cycle phase transition|
|cell cycle phase transition|
|nuclear division|
|protein polyubiquitination|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|proteasomal protein catabolic process|
|cell division|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|mitotic cell cycle process|
|cellular protein catabolic process|
|positive regulation of transferase activity|
|mitotic cell cycle|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|cellular protein-containing complex assembly|
|cellular homeostasis|
|cellular macromolecule catabolic process|
|regulation of transferase activity|
|protein modification by small protein conjugation or removal|
|cell cycle process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|positive regulation of protein modification process|
|proteolysis|
|cell cycle|
|positive regulation of catalytic activity|
|ATP binding|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|homeostatic process|
|positive regulation of protein metabolic process|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|regulation of protein modification process|
|protein-containing complex subunit organization|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|-4.33|
|[[:results:exp187|proTAME 5μM R04 exp187]]|-3.39|
|[[:results:exp177|Apcin 25μM plus proTAME 2μM R04 exp177]]|-3.24|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-1.99|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|-1.89|
|[[:results:exp36|TRAIL 50ng/ml R00 exp36]]|-1.79|
|[[:results:exp343|Centrinone 0.5μM R07 exp343]]|-1.78|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|-1.78|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:ube2c|UBE2C]]|0.566|
|[[:human genes:a:anapc13|ANAPC13]]|0.5|
|[[:human genes:k:kif20a|KIF20A]]|0.465|
|[[:human genes:m:mad2l1bp|MAD2L1BP]]|0.418|
|[[:human genes:s:ska1|SKA1]]|0.418|
|[[:human genes:a:anapc15|ANAPC15]]|0.415|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 20/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|4/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|1/21|
|liver|3/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|0/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7886
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.77 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE2S Expression in NALM6 Cells: 7.77'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>