======= UBE4B =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBE4B
  * **<color #00a2e8>Official Name</color>**: ubiquitination factor E4B
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10277|10277]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O95155|O95155]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBE4B&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBE4B|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613565|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Ubiquitin-protein ligase that probably functions as an E3 ligase in conjunction with specific E1 and E2 ligases. May also function as an E4 ligase mediating the assembly of polyubiquitin chains on substrates ubiquitinated by another E3 ubiquitin ligase. {ECO:0000250|UniProtKB:P54860, ECO:0000250|UniProtKB:Q9ES00}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|U-box|
|Ufd2P core|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|granzyme-mediated apoptotic signaling pathway|
|ubiquitin-ubiquitin ligase activity|
|ventricular trabecula myocardium morphogenesis|
|heart trabecula morphogenesis|
|trabecula morphogenesis|
|ventricular cardiac muscle tissue morphogenesis|
|ventricular cardiac muscle tissue development|
|protein monoubiquitination|
|protein autoubiquitination|
|cardiac muscle tissue morphogenesis|
|ubiquitin-dependent ERAD pathway|
|cardiac ventricle morphogenesis|
|ATPase binding|
|muscle tissue morphogenesis|
|muscle organ morphogenesis|
|ERAD pathway|
|ubiquitin ligase complex|
|cardiac chamber morphogenesis|
|cardiac ventricle development|
|response to UV|
|cardiac muscle tissue development|
|cardiac chamber development|
|heart morphogenesis|
|response to endoplasmic reticulum stress|
|striated muscle tissue development|
|apoptotic signaling pathway|
|muscle organ development|
|muscle tissue development|
|protein polyubiquitination|
|response to light stimulus|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|enzyme binding|
|proteasomal protein catabolic process|
|response to radiation|
|muscle structure development|
|heart development|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|tissue morphogenesis|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|protein modification by small protein conjugation|
|neuron development|
|circulatory system development|
|cellular macromolecule catabolic process|
|apoptotic process|
|animal organ morphogenesis|
|protein modification by small protein conjugation or removal|
|response to organonitrogen compound|
|neuron differentiation|
|macromolecule catabolic process|
|programmed cell death|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|cell death|
|plasma membrane bounded cell projection organization|
|response to abiotic stimulus|
|cell projection organization|
|proteolysis|
|ATP binding|
|generation of neurons|
|neurogenesis|
|cell development|
|cellular response to stress|
|tissue development|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|-3.55|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-3.11|
|[[:results:exp125|GSK461364A 0.005μM R03 exp125]]|-2.84|
|[[:results:exp459|Bleomycin 5μM R08 exp459]]|-2.65|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|-2.56|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-2.56|
|[[:results:exp184|Ixabepilone 0.004 to 0.005μM on day4 R04 exp184]]|-2.5|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.24|
|[[:results:exp97|BI-6727 0.0125μM R03 exp97]]|-2.23|
|[[:results:exp499|LY2090314 0.003μM R08 exp499]]|-2.22|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|-2.14|
|[[:results:exp106|UM131593 0.2μM R03 exp106]]|-2.05|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-2.05|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-2.04|
|[[:results:exp231|Epothilone-B 0.0015μM R05 exp231]]|-2.03|
|[[:results:exp240|Pyridostatin 4μM R05 exp240]]|-1.91|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|-1.85|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.85|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|-1.83|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|-1.82|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|-1.79|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|-1.71|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.73|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|1.79|
|[[:results:exp510|Nicotine 3000μM R08 exp510]]|1.82|
|[[:results:exp431|Rotenone 0.07μM R08 exp431]]|1.93|
|[[:results:exp321|ABT-702 5μM plus Deferoxamine 11μM R07 exp321]]|1.94|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|1.99|
|[[:results:exp30|Rapamycin 10μM R00 exp30]]|2.01|
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|2.12|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|2.16|
|[[:results:exp374|Latrunculin-B 10μM R07 exp374]]|2.25|
|[[:results:exp453|B02 10μM R08 exp453]]|2.26|
|[[:results:exp409|THZ531 0.11μM R07 exp409]]|2.32|
|[[:results:exp410|THZ531 0.11 to 0.125μM on day4 R07 exp410]]|2.35|
|[[:results:exp420|Tunicamycin 0.04 to 0.125μM  on day4 R07 exp420]]|2.37|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.47|
|[[:results:exp349|Cytochalasin-B 5μM R07 exp349]]|2.69|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|3.28|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|4.12|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tacc3|TACC3]]|0.417|
|[[:human genes:i:itpk1|ITPK1]]|0.406|
|[[:human genes:c:cltc|CLTC]]|0.403|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 18477
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.04 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBE4B Expression in NALM6 Cells: 6.04'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>