======= UBQLN4 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBQLN4
  * **<color #00a2e8>Official Name</color>**: ubiquilin 4
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56893|56893]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NRR5|Q9NRR5]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBQLN4&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBQLN4|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605440|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in the regulation of protein degradation via the ubiquitin-proteasome system (UPS). Mediates the proteasomal targeting of misfolded or accumulated proteins for degradation by binding (via UBA domain) to their polyubiquitin chains and by interacting (via ubiquitin-like domain) with the subunits of the proteasome (Ref. 6). Plays a role in the regulation of the proteasomal degradation of non-ubiquitinated GJA1 (By similarity). Acts as an adapter protein that recruits UBQLN1 to the autophagy machinery. Mediates the association of UBQLN1 with autophagosomes and the autophagy-related protein LC3 (MAP1LC3A/B/C) and may assist in the maturation of autophagosomes to autolysosomes by mediating autophagosome-lysosome fusion (PubMed:23459205). {ECO:0000250|UniProtKB:Q99NB8, ECO:0000269|PubMed:15280365, ECO:0000269|PubMed:23459205}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ubiquitin|
|UBA|
|Rad60-SLD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nuclear proteasome complex|
|negative regulation of autophagosome maturation|
|cytosolic proteasome complex|
|regulation of autophagosome maturation|
|site of DNA damage|
|negative regulation of double-strand break repair via homologous recombination|
|polyubiquitin modification-dependent protein binding|
|negative regulation of double-strand break repair|
|negative regulation of macroautophagy|
|negative regulation of DNA repair|
|negative regulation of DNA recombination|
|regulation of double-strand break repair via homologous recombination|
|autophagosome|
|negative regulation of protein complex disassembly|
|regulation of double-strand break repair|
|negative regulation of response to DNA damage stimulus|
|negative regulation of autophagy|
|regulation of DNA recombination|
|regulation of protein complex disassembly|
|negative regulation of DNA metabolic process|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|regulation of DNA repair|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of macroautophagy|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to DNA damage stimulus|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|cytoplasmic vesicle|
|autophagy|
|process utilizing autophagic mechanism|
|negative regulation of catabolic process|
|regulation of autophagy|
|regulation of DNA metabolic process|
|regulation of protein catabolic process|
|DNA repair|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|perinuclear region of cytoplasm|
|negative regulation of cellular component organization|
|regulation of proteolysis|
|regulation of cellular response to stress|
|DNA metabolic process|
|cellular response to DNA damage stimulus|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|endoplasmic reticulum membrane|
|regulation of catabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|identical protein binding|
|proteolysis|
|regulation of organelle organization|
|negative regulation of nucleobase-containing compound metabolic process|
|regulation of response to stress|
|negative regulation of response to stimulus|
|cellular response to stress|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp466|Cannabidiol 20μM R08 exp466]]|-2.03|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.92|
|[[:results:exp25|Oligomycin-A 2μM R00 exp25]]|-1.85|
|[[:results:exp306|Rapamycin 2μM R07 exp306]]|-1.81|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:rrm1|RRM1]]|0.691|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 4/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|1/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 9845
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBQLN4 Expression in NALM6 Cells: 6.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>