======= UBR2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UBR2
  * **<color #00a2e8>Official Name</color>**: ubiquitin protein ligase E3 component n-recognin 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23304|23304]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8IWV8|Q8IWV8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UBR2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UBR2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609134|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Plays a critical role in chromatin inactivation and chromosome-wide transcriptional silencing during meiosis via ubiquitination of histone H2A. Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. Required for spermatogenesis, promotes, with Tex19.1, SPO11-dependent recombination foci to accumulate and drive robust homologous chromosome synapsis (By similarity). Polyubiquitinates LINE-1 retrotransposon encoded, LIRE1, which induces degradation, inhibiting LINE-1 retranstoposon mobilization (By similarity). {ECO:0000250|UniProtKB:Q6WKZ8, ECO:0000269|PubMed:15548684, ECO:0000269|PubMed:20298436, ECO:0000269|PubMed:20835242}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|ClpS|
|zf-UBR|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-dependent protein catabolic process via the N-end rule pathway|
|leucine binding|
|cellular response to leucine|
|response to leucine|
|negative regulation of transposition|
|regulation of transposition|
|histone H2A ubiquitination|
|male meiosis I|
|histone ubiquitination|
|male meiotic nuclear division|
|negative regulation of TOR signaling|
|reciprocal meiotic recombination|
|homologous recombination|
|chromatin silencing|
|chromatin organization involved in negative regulation of transcription|
|cellular response to amino acid stimulus|
|chromatin organization involved in regulation of transcription|
|negative regulation of gene expression, epigenetic|
|regulation of TOR signaling|
|ubiquitin ligase complex|
|meiosis I|
|meiosis I cell cycle process|
|response to amino acid|
|chromatin|
|meiotic nuclear division|
|gene silencing|
|meiotic cell cycle process|
|cellular response to acid chemical|
|ubiquitin protein ligase activity|
|DNA recombination|
|meiotic cell cycle|
|regulation of gene expression, epigenetic|
|nuclear division|
|protein polyubiquitination|
|organelle fission|
|proteasome-mediated ubiquitin-dependent protein catabolic process|
|response to acid chemical|
|proteasomal protein catabolic process|
|cellular process involved in reproduction in multicellular organism|
|histone modification|
|covalent chromatin modification|
|negative regulation of intracellular signal transduction|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|spermatogenesis|
|modification-dependent macromolecule catabolic process|
|male gamete generation|
|proteolysis involved in cellular protein catabolic process|
|cellular response to organonitrogen compound|
|cellular protein catabolic process|
|cellular response to nitrogen compound|
|protein catabolic process|
|protein ubiquitination|
|gamete generation|
|chromatin organization|
|DNA metabolic process|
|protein modification by small protein conjugation|
|multicellular organismal reproductive process|
|sexual reproduction|
|zinc ion binding|
|multicellular organism reproduction|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|multi-organism reproductive process|
|cell cycle process|
|response to organonitrogen compound|
|macromolecule catabolic process|
|cellular response to oxygen-containing compound|
|organonitrogen compound catabolic process|
|chromosome organization|
|response to nitrogen compound|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|negative regulation of signal transduction|
|proteolysis|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cell communication|
|negative regulation of signaling|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|negative regulation of response to stimulus|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of intracellular signal transduction|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-1.78|
|[[:results:exp295|Pyronaridine 1μM R06 exp295]]|1.72|
|[[:results:exp416|Tubacin 1.6μM R07 exp416]]|1.74|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|1.84|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.84|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.92|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/25|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/15|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/14|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/7|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 14004
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UBR2 Expression in NALM6 Cells: 6.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>