======= UCN =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UCN
  * **<color #00a2e8>Official Name</color>**: urocortin
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7349|7349]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P55089|P55089]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UCN&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UCN|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600945|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Acts in vitro to stimulate the secretion of adrenocorticotropic hormone (ACTH) (PubMed:8612563). Binds with high affinity to CRF receptor types 1, 2-alpha, and 2-beta (PubMed:8612563). Plays a role in the establishment of normal hearing thresholds (By similarity). Reduces food intake and regulates ghrelin levels in gastric body and plasma (By similarity). {ECO:0000250|UniProtKB:P55090, ECO:0000250|UniProtKB:P81615, ECO:0000269|PubMed:8612563}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|CRF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|histone deacetylase inhibitor activity|
|corticotropin-releasing hormone activity|
|gastric motility|
|gastric emptying|
|corticotropin-releasing hormone receptor 1 binding|
|corticotropin-releasing hormone receptor 2 binding|
|positive regulation of cortisol secretion|
|positive regulation of corticotropin secretion|
|negative regulation of glucagon secretion|
|regulation of cortisol secretion|
|negative regulation of epinephrine secretion|
|negative regulation of histone deacetylation|
|regulation of corticotropin secretion|
|positive regulation of glucocorticoid secretion|
|positive regulation of behavioral fear response|
|positive regulation of fear response|
|negative regulation of gastric acid secretion|
|pancreatic juice secretion|
|regulation of epinephrine secretion|
|varicosity|
|positive regulation of corticosteroid hormone secretion|
|regulation of fear response|
|regulation of behavioral fear response|
|regulation of glucagon secretion|
|drinking behavior|
|negative regulation of feeding behavior|
|regulation of glucocorticoid secretion|
|negative regulation of cell size|
|positive regulation of steroid hormone secretion|
|positive regulation of vascular permeability|
|regulation of gastric acid secretion|
|positive regulation of cardiac muscle contraction|
|negative regulation of appetite|
|negative regulation of response to food|
|positive regulation of striated muscle contraction|
|negative regulation of catecholamine secretion|
|negative regulation of response to extracellular stimulus|
|negative regulation of response to nutrient levels|
|regulation of corticosteroid hormone secretion|
|negative regulation of necrotic cell death|
|negative regulation of behavior|
|activation of protein kinase A activity|
|regulation of response to food|
|negative regulation of digestive system process|
|regulation of steroid hormone secretion|
|secretion by tissue|
|positive regulation of calcium ion import|
|positive regulation of cAMP-mediated signaling|
|regulation of appetite|
|positive regulation of collagen biosynthetic process|
|regulation of response to nutrient levels|
|negative regulation of amine transport|
|regulation of response to extracellular stimulus|
|positive regulation of collagen metabolic process|
|response to auditory stimulus|
|startle response|
|regulation of histone deacetylation|
|positive regulation of behavior|
|neuropeptide hormone activity|
|regulation of feeding behavior|
|regulation of necrotic cell death|
|response to pain|
|positive regulation of response to drug|
|regulation of collagen biosynthetic process|
|positive regulation of DNA replication|
|regulation of vascular permeability|
|positive regulation of heart contraction|
|regulation of calcium ion import|
|regulation of digestive system process|
|regulation of collagen metabolic process|
|negative regulation of histone modification|
|regulation of protein deacetylation|
|regulation of endocrine process|
|positive regulation of muscle contraction|
|negative regulation of blood pressure|
|negative regulation of peptide hormone secretion|
|regulation of cAMP-mediated signaling|
|axon terminus|
|intraspecies interaction between organisms|
|social behavior|
|positive regulation of blood vessel diameter|
|negative regulation of chromatin organization|
|positive regulation of lipid transport|
|regulation of catecholamine secretion|
|negative regulation of hormone secretion|
|multi-organism behavior|
|multicellular organismal response to stress|
|regulation of synaptic transmission, glutamatergic|
|positive regulation of blood circulation|
|regulation of behavior|
|digestive system process|
|body fluid secretion|
|regulation of cardiac muscle contraction|
|associative learning|
|aerobic respiration|
|positive regulation of lipid localization|
|feeding behavior|
|regulation of striated muscle contraction|
|regulation of amine transport|
|positive regulation of interleukin-6 production|
|positive regulation of peptide hormone secretion|
|regulation of response to drug|
|positive regulation of peptidyl-serine phosphorylation|
|neuropeptide signaling pathway|
|neuromuscular process|
|regulation of lipid transport|
|regulation of DNA replication|
|digestion|
|positive regulation of calcium ion transport|
|positive regulation of translation|
|positive regulation of hormone secretion|
|negative regulation of chromosome organization|
|perikaryon|
|response to estradiol|
|regulation of peptidyl-serine phosphorylation|
|regulation of lipid localization|
|regulation of tube diameter|
|regulation of blood vessel diameter|
|negative regulation of peptide secretion|
|regulation of tube size|
|regulation of interleukin-6 production|
|response to glucocorticoid|
|sensory perception of sound|
|regulation of histone modification|
|learning|
|positive regulation of cellular amide metabolic process|
|regulation of muscle contraction|
|response to corticosteroid|
|positive regulation of cell growth|
|sensory perception of mechanical stimulus|
|cellular respiration|
|vascular process in circulatory system|
|female pregnancy|
|regulation of blood pressure|
|regulation of cell size|
|regulation of chromatin organization|
|negative regulation of secretion by cell|
|negative regulation of neuron death|
|regulation of peptide hormone secretion|
|multi-multicellular organism process|
|response to mechanical stimulus|
|negative regulation of secretion|
|energy derivation by oxidation of organic compounds|
|regulation of muscle system process|
|regulation of heart contraction|
|regulation of calcium ion transport|
|positive regulation of growth|
|learning or memory|
|regulation of hormone secretion|
|positive regulation of ion transport|
|regulation of blood circulation|
|positive regulation of peptide secretion|
|cognition|
|regulation of neuron death|
|response to steroid hormone|
|activation of protein kinase activity|
|regulation of chromosome organization|
|regulation of translation|
|negative regulation of response to external stimulus|
|negative regulation of organelle organization|
|regulation of cellular component size|
|regulation of metal ion transport|
|response to oxidative stress|
|blood circulation|
|circulatory system process|
|positive regulation of secretion by cell|
|regulation of cellular amide metabolic process|
|regulation of cell growth|
|dendrite|
|generation of precursor metabolites and energy|
|positive regulation of secretion|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|positive regulation of cytokine production|
|positive regulation of defense response|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|inflammatory response|
|response to nutrient levels|
|regulation of anatomical structure size|
|posttranscriptional regulation of gene expression|
|response to extracellular stimulus|
|regulation of hormone levels|
|positive regulation of protein kinase activity|
|behavior|
|positive regulation of kinase activity|
|regulation of system process|
|negative regulation of protein modification process|
|positive regulation of transferase activity|
|neuron projection development|
|regulation of growth|
|regulation of cytokine production|
|regulation of ion transport|
|negative regulation of cellular component organization|
|regulation of peptide transport|
|regulation of secretion by cell|
|regulation of defense response|
|regulation of protein kinase activity|
|regulation of secretion|
|neuron development|
|response to lipid|
|regulation of kinase activity|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|response to hormone|
|response to organic cyclic compound|
|oxidation-reduction process|
|sensory perception|
|regulation of transferase activity|
|positive regulation of transport|
|negative regulation of cell death|
|multi-organism reproductive process|
|neuron differentiation|
|positive regulation of protein phosphorylation|
|positive regulation of intracellular signal transduction|
|negative regulation of cellular protein metabolic process|
|positive regulation of phosphorylation|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|secretion|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphate metabolic process|
|positive regulation of phosphorus metabolic process|
|response to abiotic stimulus|
|cell projection organization|
|negative regulation of multicellular organismal process|
|positive regulation of transcription by RNA polymerase II|
|positive regulation of protein modification process|
|regulation of organelle organization|
|G protein-coupled receptor signaling pathway|
|defense response|
|negative regulation of cell communication|
|negative regulation of signaling|
|nervous system process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|regulation of protein phosphorylation|
|response to endogenous stimulus|
|regulation of response to stress|
|generation of neurons|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of phosphorylation|
|extracellular space|
|positive regulation of cellular protein metabolic process|
|negative regulation of response to stimulus|
|neurogenesis|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|cell development|
|positive regulation of signal transduction|
|regulation of cell death|
|positive regulation of protein metabolic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|positive regulation of cell communication|
|positive regulation of signaling|
|regulation of intracellular signal transduction|
|regulation of protein modification process|
|regulation of transport|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|extracellular region|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|1/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3462
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 0.34 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UCN Expression in NALM6 Cells: 0.34'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>