======= UFL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UFL1
  * **<color #00a2e8>Official Name</color>**: UFM1 specific ligase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23376|23376]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O94874|O94874]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UFL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UFL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613372|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  E3 protein ligase that mediates ufmylation, the covalent attachment of the ubiquitin-like modifier UFM1 to substrate proteins, a post-translational modification on lysine residues of proteins that may play a crucial role in a number of cellular processes. Mediates DDRGK1 ufmylation and may regulate the proteasomal degradation of DDRGK1 and CDK5RAP3 thereby modulating NF-kappa-B signaling (PubMed:20018847, PubMed:20164180, PubMed:20228063, PubMed:25219498). May also through TRIP4 ufmylation play a role in nuclear receptors-mediated transcription (PubMed:25219498). May play a role in the unfolded protein response, mediating the ufmylation of multiple proteins in response to endoplasmic reticulum stress (PubMed:23152784). {ECO:0000269|PubMed:20018847, ECO:0000269|PubMed:20164180, ECO:0000269|PubMed:20228063, ECO:0000269|PubMed:23152784, ECO:0000269|PubMed:25219498}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DUF2042|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFM1 transferase activity|
|protein polyufmylation|
|protein K69-linked ufmylation|
|protein ufmylation|
|response to L-glutamate|
|positive regulation of glial cell proliferation|
|regulation of glial cell proliferation|
|regulation of intracellular estrogen receptor signaling pathway|
|positive regulation of gliogenesis|
|negative regulation of protein ubiquitination|
|regulation of intracellular steroid hormone receptor signaling pathway|
|negative regulation of NF-kappaB transcription factor activity|
|negative regulation of protein modification by small protein conjugation or removal|
|response to amino acid|
|regulation of gliogenesis|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|osteoblast differentiation|
|regulation of ubiquitin-dependent protein catabolic process|
|negative regulation of DNA-binding transcription factor activity|
|regulation of proteasomal protein catabolic process|
|regulation of protein ubiquitination|
|response to nutrient|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of protein modification by small protein conjugation or removal|
|regulation of cellular protein catabolic process|
|response to endoplasmic reticulum stress|
|ossification|
|neuron projection|
|response to acid chemical|
|regulation of protein catabolic process|
|regulation of DNA-binding transcription factor activity|
|positive regulation of neurogenesis|
|response to nutrient levels|
|response to extracellular stimulus|
|positive regulation of nervous system development|
|positive regulation of cell development|
|negative regulation of protein modification process|
|protein-containing complex|
|regulation of proteolysis|
|protein modification by small protein conjugation|
|regulation of neurogenesis|
|regulation of cellular catabolic process|
|negative regulation of apoptotic process|
|negative regulation of programmed cell death|
|positive regulation of cell population proliferation|
|regulation of nervous system development|
|regulation of cell development|
|endoplasmic reticulum membrane|
|positive regulation of cell differentiation|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cell death|
|response to organonitrogen compound|
|endoplasmic reticulum|
|response to drug|
|regulation of protein localization|
|negative regulation of cellular protein metabolic process|
|response to nitrogen compound|
|negative regulation of protein metabolic process|
|negative regulation of molecular function|
|positive regulation of developmental process|
|generation of neurons|
|regulation of apoptotic process|
|response to oxygen-containing compound|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|neurogenesis|
|regulation of cell death|
|cellular response to stress|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|regulation of protein modification process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.17|
|[[:results:exp234|Ethanol 0.01 R05 exp234]]|-2.16|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.95|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-1.94|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|-1.75|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.72|
|[[:results:exp535|Trimetrexate 0.03μM R08 exp535]]|1.72|
|[[:results:exp492|iCRT14 30μM R08 exp492]]|1.76|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.76|
|[[:results:exp439|QNZ 0.01μM R08 exp439]]|1.76|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.78|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|1.84|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.84|
|[[:results:exp505|ML-792 0.2μM R08 exp505]]|1.88|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|1.93|
|[[:results:exp216|Erlotinib 10μM R05 exp216]]|1.97|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.98|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|2.76|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:u:uba5|UBA5]]|0.702|
|[[:human genes:c:c1orf27|C1orf27]]|0.667|
|[[:human genes:u:ufsp2|UFSP2]]|0.656|
|[[:human genes:u:ufc1|UFC1]]|0.606|
|[[:human genes:u:ufm1|UFM1]]|0.599|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.512|
|[[:human genes:u:ube2j1|UBE2J1]]|0.42|
|[[:human genes:a:alg6|ALG6]]|0.416|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 29/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|2/28|
|bone|0/26|
|breast|0/33|
|central nervous system|3/56|
|cervix|0/4|
|colorectal|2/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|3/20|
|lung|1/75|
|lymphocyte|1/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|1/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5012
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.27 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UFL1 Expression in NALM6 Cells: 6.27'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>