======= UFSP2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UFSP2
  * **<color #00a2e8>Official Name</color>**: UFM1 specific peptidase 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55325|55325]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NUQ7|Q9NUQ7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UFSP2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UFSP2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611482|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a highly conserved cysteine protease. The protein cleaves two C-terminal residues from ubiquitin-fold modifier 1, a ubiquitin-like post-translational modifier protein. Activation of ubiquitin-fold modifier 1 by the encoded protein exposes a C-terminal glycine residue that allows interaction with other proteins and transfer to its target protein. An allelic variant of this gene has been associated with Beukes hip dysplasia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation. {ECO:0000269|PubMed:25219498}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase C78|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UFM1 hydrolase activity|
|thiolester hydrolase activity|
|regulation of intracellular estrogen receptor signaling pathway|
|regulation of intracellular steroid hormone receptor signaling pathway|
|endoplasmic reticulum|
|proteolysis|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|-3.07|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|-2.39|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-2.21|
|[[:results:exp352|Dexamethasone 0.006 to 0.015μM on day4 R07 exp352]]|-2.13|
|[[:results:exp498|Lead acetate 2000μM R08 exp498 no dilution day6]]|-1.88|
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-1.82|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|-1.76|
|[[:results:exp407|Thapsigargin 0.005μM R07 exp407]]|-1.71|
|[[:results:exp17|DABN 20μM R00 exp17]]|1.71|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.73|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|1.73|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.74|
|[[:results:exp488|Hippuristanol 0.12μM R08 exp488]]|1.77|
|[[:results:exp7|Bortezomib 0.05μM R00 exp7]]|1.85|
|[[:results:exp94|Nocodazole 0.1μM R03 exp94]]|1.92|
|[[:results:exp400|Senexin-A 25μM R07 exp400]]|1.93|
|[[:results:exp98|BI-6727 0.04μM R03 exp98]]|1.95|
|[[:results:exp271|CCT251545 0.2μM R06 exp271]]|1.96|
|[[:results:exp489|Hippuristanol 0.12μM R08 exp489 no dilution day6]]|1.98|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.03|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|2.23|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.27|
|[[:results:exp292|Menadione 5μM R06 exp292]]|2.27|
|[[:results:exp95|BI-2536 0.0042μM R03 exp95]]|3.1|
|[[:results:exp103|Taxol 0.004μM R03 exp103]]|3.17|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:c1orf27|C1orf27]]|0.771|
|[[:human genes:u:uba5|UBA5]]|0.735|
|[[:human genes:u:ufc1|UFC1]]|0.731|
|[[:human genes:u:ufm1|UFM1]]|0.683|
|[[:human genes:u:ufl1|UFL1]]|0.656|
|[[:human genes:d:ddrgk1|DDRGK1]]|0.579|
|[[:human genes:u:ube2j1|UBE2J1]]|0.483|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.477|
|[[:human genes:a:alg6|ALG6]]|0.477|
|[[:human genes:d:dnajb11|DNAJB11]]|0.452|
|[[:human genes:s:sbds|SBDS]]|0.445|
|[[:human genes:t:tmed10|TMED10]]|0.437|
|[[:human genes:a:alg5|ALG5]]|0.426|
|[[:human genes:a:alg1|ALG1]]|0.41|
|[[:human genes:s:sec62|SEC62]]|0.406|
|[[:human genes:a:atp5o|ATP5O]]|0.406|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 3/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|2/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 5651
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.87 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UFSP2 Expression in NALM6 Cells: 3.87'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>