======= UGGT1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGGT1
  * **<color #00a2e8>Official Name</color>**: UDP-glucose glycoprotein glucosyltransferase 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=56886|56886]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NYU2|Q9NYU2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGGT1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGGT1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/605897|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Recognizes glycoproteins with minor folding defects. Reglucosylates single N-glycans near the misfolded part of the protein, thus providing quality control for protein folding in the endoplasmic reticulum. Reglucosylated proteins are recognized by calreticulin for recycling to the endoplasmic reticulum and refolding or degradation. {ECO:0000269|PubMed:10694380}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDP-g GGTase|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|UDP-glucose:glycoprotein glucosyltransferase activity|
|UDP-glucosylation|
|UDP-glucose metabolic process|
|ER-associated misfolded protein catabolic process|
|endoplasmic reticulum mannose trimming|
|protein demannosylation|
|protein alpha-1,2-demannosylation|
|endoplasmic reticulum quality control compartment|
|cellular response to misfolded protein|
|response to misfolded protein|
|protein quality control for misfolded or incompletely synthesized proteins|
|protein deglycosylation|
|protein N-linked glycosylation via asparagine|
|peptidyl-asparagine modification|
|de novo posttranslational protein folding|
|nucleotide-sugar metabolic process|
|de novo protein folding|
|endoplasmic reticulum-Golgi intermediate compartment|
|protein N-linked glycosylation|
|ERAD pathway|
|unfolded protein binding|
|cellular response to topologically incorrect protein|
|response to topologically incorrect protein|
|protein folding|
|response to endoplasmic reticulum stress|
|protein glycosylation|
|macromolecule glycosylation|
|glycosylation|
|endoplasmic reticulum lumen|
|glycoprotein biosynthetic process|
|proteasomal protein catabolic process|
|glycoprotein metabolic process|
|nucleobase-containing small molecule metabolic process|
|proteolysis involved in cellular protein catabolic process|
|protein-containing complex|
|cellular protein catabolic process|
|carbohydrate derivative biosynthetic process|
|protein catabolic process|
|peptidyl-amino acid modification|
|cellular macromolecule catabolic process|
|response to organonitrogen compound|
|endoplasmic reticulum|
|carbohydrate derivative metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|response to nitrogen compound|
|proteolysis|
|organonitrogen compound biosynthetic process|
|cellular response to stress|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp245|UM0011500 5μM R05 exp245]]|-2.55|
|[[:results:exp246|UM0011500 10μM R05 exp246]]|-2.34|
|[[:results:exp226|Cerivastatin 0.15μM R05 exp226]]|-1.97|
|[[:results:exp444|THZ531 0.225μM R08 exp444]]|-1.73|
|[[:results:exp135|MS023 7μM R03 exp135]]|1.7|
|[[:results:exp275|Citral 75μM R06 exp275]]|1.71|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|1.72|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.77|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.78|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|1.82|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.88|
|[[:results:exp42|BI-6727 0.001μM R01 exp42]]|1.89|
|[[:results:exp122|Golgicide-A 4μM R03 exp122]]|1.9|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|1.91|
|[[:results:exp320|ABT-702 5μM plus CoCl2 18μM R07 exp320]]|1.98|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|1.99|
|[[:results:exp264|Arsenate 40μM R06 exp264]]|2.04|
|[[:results:exp506|Momordin-Ic 10μM R08 exp506]]|2.29|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.35|
|[[:results:exp236|GSK2606414 1μM R05 exp236]]|2.35|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6382
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 8.93 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGGT1 Expression in NALM6 Cells: 8.93'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>