======= UGT2B17 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UGT2B17
  * **<color #00a2e8>Official Name</color>**: UDP glucuronosyltransferase family 2 member B17
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7367|7367]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75795|O75795]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UGT2B17&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UGT2B17|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601903|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the uridine diphosphoglucuronosyltransferase protein family. The encoded enzyme catalyzes the transfer of glucuronic acid from uridine diphosphoglucuronic acid to a diverse array of substrates including steroid hormones and lipid-soluble drugs. This process, known as glucuronidation, is an intermediate step in the metabolism of steroids. Copy number variation in this gene is associated with susceptibility to osteoporosis.[provided by RefSeq, Apr 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. The major substrates of this isozyme are eugenol > 4-methylumbelliferone > dihydrotestosterone (DHT) > androstane-3-alpha,17-beta-diol (3-alpha-diol) > testosterone > androsterone (ADT).

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UDPGT|
|Glyco tran 28 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|cellular glucuronidation|
|UDP-glycosyltransferase activity|
|uronic acid metabolic process|
|glucuronate metabolic process|
|retinoic acid binding|
|glucuronosyltransferase activity|
|monosaccharide metabolic process|
|steroid metabolic process|
|carbohydrate metabolic process|
|monocarboxylic acid metabolic process|
|intracellular membrane-bounded organelle|
|carboxylic acid metabolic process|
|endoplasmic reticulum membrane|
|oxoacid metabolic process|
|organic acid metabolic process|
|lipid metabolic process|
|small molecule metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='default' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
No hits were found.
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 16302
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -5.6 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UGT2B17 Expression in NALM6 Cells: -5.6'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>