======= UNC13A =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNC13A
  * **<color #00a2e8>Official Name</color>**: unc-13 homolog A
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23025|23025]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UPW8|Q9UPW8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNC13A&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNC13A|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/609894|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the UNC13 family. UNC13 proteins bind to phorbol esters and diacylglycerol and play important roles in neurotransmitter release at synapses. Single nucleotide polymorphisms in this gene may be associated with sporadic amyotrophic lateral sclerosis. [provided by RefSeq, Feb 2012]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003). {ECO:0000250, ECO:0000269|PubMed:23999003}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|C2|
|Membr traf MHD|
|DUF1041|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dense core granule priming|
|neuronal dense core vesicle exocytosis|
|presynaptic dense core vesicle exocytosis|
|dense core granule exocytosis|
|positive regulation of synaptic plasticity|
|synaptic vesicle docking|
|diacylglycerol binding|
|synaptic vesicle maturation|
|presynaptic active zone cytoplasmic component|
|regulation of short-term neuronal synaptic plasticity|
|synaptic vesicle priming|
|positive regulation of glutamate receptor signaling pathway|
|calcium ion-regulated exocytosis of neurotransmitter|
|amyloid-beta metabolic process|
|positive regulation of neurotransmitter secretion|
|positive regulation of dendrite extension|
|calyx of Held|
|regulation of dendrite extension|
|syntaxin-1 binding|
|innervation|
|synaptic transmission, glutamatergic|
|regulation of amyloid precursor protein catabolic process|
|presynaptic active zone|
|positive regulation of neurotransmitter transport|
|vesicle docking involved in exocytosis|
|calcium-ion regulated exocytosis|
|neuromuscular junction development|
|terminal bouton|
|regulation of neuronal synaptic plasticity|
|vesicle docking|
|synaptic vesicle exocytosis|
|regulation of glutamate receptor signaling pathway|
|exocytic process|
|synaptic vesicle membrane|
|regulation of synaptic transmission, glutamatergic|
|presynaptic membrane|
|neuromuscular junction|
|nerve development|
|neurotransmitter secretion|
|signal release from synapse|
|regulation of neurotransmitter secretion|
|phospholipid binding|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|regulation of neurotransmitter transport|
|positive regulation of synaptic transmission|
|positive regulation of cell growth|
|signal release|
|organelle localization by membrane tethering|
|positive regulation of developmental growth|
|neurotransmitter transport|
|membrane docking|
|regulation of synaptic plasticity|
|calmodulin binding|
|developmental maturation|
|positive regulation of growth|
|synapse organization|
|positive regulation of neuron projection development|
|vesicle organization|
|neuron projection|
|regulation of developmental growth|
|glutamatergic synapse|
|regulation of neurotransmitter levels|
|positive regulation of neuron differentiation|
|positive regulation of cell projection organization|
|positive regulation of secretion by cell|
|regulation of cell growth|
|chemical synaptic transmission|
|anterograde trans-synaptic signaling|
|positive regulation of secretion|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|positive regulation of neurogenesis|
|regulation of cell morphogenesis|
|regulation of neuron projection development|
|peptide metabolic process|
|positive regulation of nervous system development|
|positive regulation of cell development|
|cell junction|
|organelle localization|
|regulation of neuron differentiation|
|regulation of growth|
|regulation of plasma membrane bounded cell projection organization|
|regulated exocytosis|
|regulation of cell projection organization|
|calcium ion binding|
|regulation of secretion by cell|
|cellular amide metabolic process|
|exocytosis|
|regulation of secretion|
|regulation of neurogenesis|
|cellular protein-containing complex assembly|
|regulation of cellular localization|
|regulation of nervous system development|
|regulation of cell development|
|positive regulation of cell differentiation|
|positive regulation of transport|
|secretion by cell|
|export from cell|
|regulation of anatomical structure morphogenesis|
|cell-cell signaling|
|secretion|
|positive regulation of cellular component organization|
|positive regulation of developmental process|
|generation of neurons|
|protein-containing complex assembly|
|neurogenesis|
|positive regulation of signal transduction|
|intracellular signal transduction|
|positive regulation of multicellular organismal process|
|regulation of cell differentiation|
|positive regulation of cell communication|
|positive regulation of signaling|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|regulation of transport|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp210|LB-100 2μM R05 exp210]]|2.1|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:c:chd4|CHD4]]|0.409|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3135
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.18 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNC13A Expression in NALM6 Cells: 1.18'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>