======= UNC13C =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UNC13C
  * **<color #00a2e8>Official Name</color>**: unc-13 homolog C
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=440279|440279]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8NB66|Q8NB66]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UNC13C&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UNC13C|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/614568|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|C1 1|
|C2|
|DUF1041|
|Membr traf MHD|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|dense core granule priming|
|neuronal dense core vesicle exocytosis|
|negative regulation of synaptic plasticity|
|presynaptic dense core vesicle exocytosis|
|dense core granule exocytosis|
|synaptic vesicle docking|
|diacylglycerol binding|
|synaptic vesicle maturation|
|presynaptic active zone cytoplasmic component|
|synaptic vesicle priming|
|parallel fiber to Purkinje cell synapse|
|calcium ion-regulated exocytosis of neurotransmitter|
|calyx of Held|
|syntaxin-1 binding|
|synaptic transmission, glutamatergic|
|presynaptic active zone|
|calcium-ion regulated exocytosis|
|vesicle docking involved in exocytosis|
|neuromuscular junction development|
|terminal bouton|
|vesicle docking|
|synaptic vesicle exocytosis|
|exocytic process|
|synaptic vesicle membrane|
|presynaptic membrane|
|neuromuscular junction|
|neurotransmitter secretion|
|signal release from synapse|
|phospholipid binding|
|synaptic vesicle cycle|
|vesicle-mediated transport in synapse|
|signal release|
|organelle localization by membrane tethering|
|membrane docking|
|neurotransmitter transport|
|regulation of synaptic plasticity|
|calmodulin binding|
|developmental maturation|
|synapse organization|
|vesicle organization|
|regulation of neurotransmitter levels|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|modulation of chemical synaptic transmission|
|regulation of trans-synaptic signaling|
|synaptic signaling|
|cell junction|
|organelle localization|
|regulated exocytosis|
|calcium ion binding|
|exocytosis|
|cellular protein-containing complex assembly|
|secretion by cell|
|export from cell|
|cell-cell signaling|
|secretion|
|protein-containing complex assembly|
|intracellular signal transduction|
|establishment of localization in cell|
|protein-containing complex subunit organization|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|-1.8|
|[[:results:exp279|D-Fructose 10000μM R06 exp279]]|-1.73|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11875
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 2.75 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UNC13C Expression in NALM6 Cells: 2.75'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>