======= UPRT =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UPRT
  * **<color #00a2e8>Official Name</color>**: uracil phosphoribosyltransferase homolog
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=139596|139596]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q96BW1|Q96BW1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UPRT&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UPRT|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300656|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes uracil phosphoribosyltransferase, which catalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. The enzyme localizes to the nucleus and cytoplasm. The protein is a potential target for rational design of drugs to treat parasitic infections and cancer. [provided by RefSeq, Nov 2009]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|pyrimidine ribonucleoside monophosphate biosynthetic process|
|UMP biosynthetic process|
|UMP metabolic process|
|pyrimidine ribonucleoside monophosphate metabolic process|
|pyrimidine nucleoside monophosphate biosynthetic process|
|pyrimidine nucleoside monophosphate metabolic process|
|pyrimidine ribonucleotide biosynthetic process|
|pyrimidine ribonucleotide metabolic process|
|ribonucleoside monophosphate biosynthetic process|
|nucleoside monophosphate biosynthetic process|
|lactation|
|pyrimidine nucleotide biosynthetic process|
|ribonucleoside monophosphate metabolic process|
|pyrimidine-containing compound biosynthetic process|
|pyrimidine nucleotide metabolic process|
|body fluid secretion|
|nucleoside monophosphate metabolic process|
|kinase activity|
|pyrimidine-containing compound metabolic process|
|nucleoside metabolic process|
|mammary gland development|
|glycosyl compound metabolic process|
|ribonucleotide biosynthetic process|
|ribose phosphate biosynthetic process|
|female pregnancy|
|multi-multicellular organism process|
|response to insulin|
|nucleotide biosynthetic process|
|nucleoside phosphate biosynthetic process|
|ribonucleotide metabolic process|
|ribose phosphate metabolic process|
|GTP binding|
|response to peptide hormone|
|gland development|
|nucleotide metabolic process|
|nucleoside phosphate metabolic process|
|response to peptide|
|regulation of body fluid levels|
|organophosphate biosynthetic process|
|nucleobase-containing small molecule metabolic process|
|carbohydrate derivative biosynthetic process|
|organophosphate metabolic process|
|response to hormone|
|multi-organism reproductive process|
|response to organonitrogen compound|
|carbohydrate derivative metabolic process|
|response to nitrogen compound|
|nucleobase-containing compound biosynthetic process|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|phosphorylation|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|reproductive process|
|reproduction|
|response to endogenous stimulus|
|response to oxygen-containing compound|
|cellular nitrogen compound biosynthetic process|
|small molecule metabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp438|NN-Diethyl-meta-toluamide 500μM R08 exp438]]|-1.96|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.76|
|[[:results:exp69|Deguelin 0.05μM R02 exp69]]|1.82|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15837
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UPRT Expression in NALM6 Cells: 3.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>