======= UQCC1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCC1
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase complex assembly factor 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=55245|55245]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NVA1|Q9NVA1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCC1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCC1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611797|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a transmembrane protein that is structurally similar to the mouse basic fibroblast growth factor repressed ZIC-binding protein. In mouse this protein may be involved in fibroblast growth factor regulated growth control. In humans, polymorphisms in this gene are associated with variation in human height and osteoarthritis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, May 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Ubiq cyt C chap|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial respiratory chain complex III assembly|
|respiratory chain complex III assembly|
|positive regulation of mitochondrial translation|
|regulation of mitochondrial translation|
|regulation of mitochondrial gene expression|
|cytochrome complex assembly|
|mitochondrial respiratory chain complex assembly|
|positive regulation of translation|
|positive regulation of cellular amide metabolic process|
|cytoplasmic vesicle|
|regulation of translation|
|mitochondrial inner membrane|
|regulation of cellular amide metabolic process|
|mitochondrion organization|
|posttranscriptional regulation of gene expression|
|cellular protein-containing complex assembly|
|protein-containing complex assembly|
|positive regulation of cellular protein metabolic process|
|positive regulation of protein metabolic process|
|protein-containing complex subunit organization|
|positive regulation of macromolecule biosynthetic process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp212|Phenformin 20μM R05 exp212]]|1.76|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.8|
|[[:results:exp162|BI-D1870 2μM R04 exp162]]|1.83|
|[[:results:exp452|Azithromycin 100μM R08 exp452]]|1.91|
|[[:results:exp470|Chloroquine 32μM R08 exp470]]|1.99|
|[[:results:exp160|Ribavirin 10 to 15μM on day4 R04 exp160]]|2.18|
|[[:results:exp143|Phenformin 20μM R03 exp143]]|2.35|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.68|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:pet117|PET117]]|0.504|
|[[:human genes:c:coq2|COQ2]]|0.491|
|[[:human genes:u:uqcc2|UQCC2]]|0.49|
|[[:human genes:c:cox11|COX11]]|0.454|
|[[:human genes:c:cox18|COX18]]|0.425|
|[[:human genes:a:aars2|AARS2]]|0.417|
|[[:human genes:t:tbrg4|TBRG4]]|0.412|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 2/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|1/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1856
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.2 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCC1 Expression in NALM6 Cells: 6.2'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>