======= UQCRC2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCRC2
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase core protein 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7385|7385]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P22695|P22695]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCRC2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCRC2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/191329|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  The protein encoded by this gene is located in the mitochondrion, where it is part of the ubiquinol-cytochrome c reductase complex (also known as complex III). This complex constitutes a part of the mitochondrial respiratory chain. Defects in this gene are a cause of mitochondrial complex III deficiency nuclear type 5. [provided by RefSeq, Jul 2015]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. The core protein 2 is required for the assembly of the complex.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Peptidase M16|
|Peptidase M16 C|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mitochondrial processing peptidase complex|
|protein processing involved in protein targeting to mitochondrion|
|mitochondrial protein processing|
|mitochondrial respiratory chain complex IV|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|protein targeting to mitochondrion|
|establishment of protein localization to mitochondrion|
|endopeptidase activity|
|protein localization to mitochondrion|
|aerobic respiration|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|metalloendopeptidase activity|
|respiratory electron transport chain|
|oxidative phosphorylation|
|protein processing|
|cellular respiration|
|electron transport chain|
|ATP metabolic process|
|mitochondrial transport|
|protein maturation|
|energy derivation by oxidation of organic compounds|
|protein-containing complex binding|
|protein targeting|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|establishment of protein localization to organelle|
|mitochondrion organization|
|protein localization to organelle|
|oxidation-reduction process|
|intracellular protein transport|
|response to drug|
|mitochondrion|
|proteolysis|
|phosphorylation|
|protein transport|
|intracellular transport|
|peptide transport|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|establishment of localization in cell|
|nitrogen compound transport|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp298|Sucrose 20000μM R06 exp298]]|-1.87|
|[[:results:exp458|Bisphenol S 100μM R08 exp458]]|-1.84|
|[[:results:exp280|Daidzin 10μM R06 exp280]]|-1.84|
|[[:results:exp493|IL-3 9ng/ml R08 exp493]]|-1.76|
|[[:results:exp131|L-74142 5μM R03 exp131]]|-1.7|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.7|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.72|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|1.75|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.9|
|[[:results:exp211|AICAR 240μM R05 exp211]]|1.96|
|[[:results:exp532|TIC10 10μM R08 exp532]]|2.04|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|2.19|
|[[:results:exp116|AICAR 240μM R03 exp116]]|2.34|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.77|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:s:sars2|SARS2]]|0.613|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.588|
|[[:human genes:m:mrps14|MRPS14]]|0.583|
|[[:human genes:m:mrpl21|MRPL21]]|0.582|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.582|
|[[:human genes:b:bcs1l|BCS1L]]|0.573|
|[[:human genes:d:dars2|DARS2]]|0.571|
|[[:human genes:d:dap3|DAP3]]|0.567|
|[[:human genes:m:mrps9|MRPS9]]|0.562|
|[[:human genes:m:mrps18a|MRPS18A]]|0.56|
|[[:human genes:r:rpusd4|RPUSD4]]|0.55|
|[[:human genes:g:gfm1|GFM1]]|0.549|
|[[:human genes:v:vars2|VARS2]]|0.547|
|[[:human genes:c:cox16|COX16]]|0.545|
|[[:human genes:s:selrc1|SELRC1]]|0.54|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.539|
|[[:human genes:m:mrp63|MRP63]]|0.539|
|[[:human genes:s:slc25a26|SLC25A26]]|0.536|
|[[:human genes:m:mrps2|MRPS2]]|0.529|
|[[:human genes:m:mrps6|MRPS6]]|0.528|
|[[:human genes:m:mrpl47|MRPL47]]|0.526|
|[[:human genes:m:mrpl23|MRPL23]]|0.522|
|[[:human genes:t:tars2|TARS2]]|0.517|
|[[:human genes:m:mrps34|MRPS34]]|0.517|
|[[:human genes:m:mrps21|MRPS21]]|0.511|
|[[:human genes:y:yars2|YARS2]]|0.508|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.507|
|[[:human genes:c:cox7b|COX7B]]|0.507|
|[[:human genes:c:coa5|COA5]]|0.503|
|[[:human genes:u:uqcrfs1|UQCRFS1]]|0.502|
|[[:human genes:m:mrps23|MRPS23]]|0.501|
|[[:human genes:c:cox6c|COX6C]]|0.501|
|[[:human genes:m:mrps5|MRPS5]]|0.499|
|[[:human genes:s:sco2|SCO2]]|0.499|
|[[:human genes:m:mrps26|MRPS26]]|0.498|
|[[:human genes:u:uqcrq|UQCRQ]]|0.497|
|[[:human genes:t:triap1|TRIAP1]]|0.497|
|[[:human genes:c:c10orf2|C10orf2]]|0.494|
|[[:human genes:c:cycs|CYCS]]|0.493|
|[[:human genes:w:wbscr16|WBSCR16]]|0.491|
|[[:human genes:f:fars2|FARS2]]|0.49|
|[[:human genes:t:tufm|TUFM]]|0.482|
|[[:human genes:p:pdss1|PDSS1]]|0.481|
|[[:human genes:f:fastkd5|FASTKD5]]|0.481|
|[[:human genes:a:atp5a1|ATP5A1]]|0.477|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.477|
|[[:human genes:m:mrpl53|MRPL53]]|0.477|
|[[:human genes:t:taz|TAZ]]|0.476|
|[[:human genes:e:elac2|ELAC2]]|0.476|
|[[:human genes:m:mrpl33|MRPL33]]|0.475|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.472|
|[[:human genes:m:mrps16|MRPS16]]|0.472|
|[[:human genes:c:cox17|COX17]]|0.47|
|[[:human genes:t:tfam|TFAM]]|0.468|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.467|
|[[:human genes:h:hars2|HARS2]]|0.465|
|[[:human genes:e:ears2|EARS2]]|0.462|
|[[:human genes:t:tefm|TEFM]]|0.46|
|[[:human genes:a:atp5o|ATP5O]]|0.458|
|[[:human genes:h:hccs|HCCS]]|0.458|
|[[:human genes:m:mrps12|MRPS12]]|0.458|
|[[:human genes:m:mrpl20|MRPL20]]|0.458|
|[[:human genes:p:pars2|PARS2]]|0.457|
|[[:human genes:q:qrsl1|QRSL1]]|0.457|
|[[:human genes:p:pnpt1|PNPT1]]|0.456|
|[[:human genes:c:coq2|COQ2]]|0.454|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.453|
|[[:human genes:c:c12orf65|C12orf65]]|0.452|
|[[:human genes:m:mrps11|MRPS11]]|0.451|
|[[:human genes:n:nars2|NARS2]]|0.448|
|[[:human genes:m:mrps24|MRPS24]]|0.446|
|[[:human genes:p:ppcs|PPCS]]|0.446|
|[[:human genes:a:adsl|ADSL]]|0.446|
|[[:human genes:n:ndufa3|NDUFA3]]|0.445|
|[[:human genes:a:atxn10|ATXN10]]|0.444|
|[[:human genes:c:coq4|COQ4]]|0.444|
|[[:human genes:c:coa3|COA3]]|0.444|
|[[:human genes:n:ndufb11|NDUFB11]]|0.443|
|[[:human genes:a:atp5b|ATP5B]]|0.442|
|[[:human genes:c:chchd4|CHCHD4]]|0.44|
|[[:human genes:n:ndufb3|NDUFB3]]|0.438|
|[[:human genes:u:uhrf1|UHRF1]]|0.437|
|[[:human genes:c:cox5a|COX5A]]|0.436|
|[[:human genes:m:mrpl27|MRPL27]]|0.436|
|[[:human genes:u:uqcr10|UQCR10]]|0.436|
|[[:human genes:a:alg13|ALG13]]|0.436|
|[[:human genes:c:cox15|COX15]]|0.436|
|[[:human genes:l:lars2|LARS2]]|0.436|
|[[:human genes:m:mrpl55|MRPL55]]|0.433|
|[[:human genes:p:ptdss1|PTDSS1]]|0.432|
|[[:human genes:m:mrpl39|MRPL39]]|0.432|
|[[:human genes:d:dpagt1|DPAGT1]]|0.432|
|[[:human genes:r:rbfa|RBFA]]|0.432|
|[[:human genes:a:atic|ATIC]]|0.43|
|[[:human genes:h:higd2a|HIGD2A]]|0.429|
|[[:human genes:m:mrpl44|MRPL44]]|0.429|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.427|
|[[:human genes:m:mrpl15|MRPL15]]|0.426|
|[[:human genes:c:cox6b1|COX6B1]]|0.426|
|[[:human genes:m:mrpl36|MRPL36]]|0.426|
|[[:human genes:a:atp5d|ATP5D]]|0.425|
|[[:human genes:c:cept1|CEPT1]]|0.425|
|[[:human genes:m:mrps10|MRPS10]]|0.425|
|[[:human genes:m:mtpap|MTPAP]]|0.424|
|[[:human genes:a:aifm1|AIFM1]]|0.424|
|[[:human genes:t:tomm20|TOMM20]]|0.424|
|[[:human genes:g:gfpt1|GFPT1]]|0.424|
|[[:human genes:n:ndufv1|NDUFV1]]|0.423|
|[[:human genes:m:mrps25|MRPS25]]|0.423|
|[[:human genes:m:mrpl18|MRPL18]]|0.419|
|[[:human genes:t:tomm22|TOMM22]]|0.419|
|[[:human genes:p:pmm2|PMM2]]|0.418|
|[[:human genes:a:atp5f1|ATP5F1]]|0.416|
|[[:human genes:r:rars2|RARS2]]|0.415|
|[[:human genes:s:ssb|SSB]]|0.414|
|[[:human genes:m:mrpl3|MRPL3]]|0.414|
|[[:human genes:t:thg1l|THG1L]]|0.413|
|[[:human genes:n:ndufb5|NDUFB5]]|0.412|
|[[:human genes:a:atp5c1|ATP5C1]]|0.41|
|[[:human genes:u:uap1|UAP1]]|0.408|
|[[:human genes:d:dohh|DOHH]]|0.408|
|[[:human genes:c:c17orf89|C17orf89]]|0.406|
|[[:human genes:f:fastkd1|FASTKD1]]|0.405|
|[[:human genes:c:coq3|COQ3]]|0.404|
|[[:human genes:v:vezt|VEZT]]|0.403|
|[[:human genes:t:trub2|TRUB2]]|0.403|
|[[:human genes:t:trnt1|TRNT1]]|0.402|
|[[:human genes:n:ndufc2|NDUFC2]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 133/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|7/28|
|bone|4/26|
|breast|6/33|
|central nervous system|3/56|
|cervix|1/4|
|colorectal|5/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|2/16|
|kidney|4/21|
|liver|6/20|
|lung|15/75|
|lymphocyte|3/16|
|ovary|1/26|
|pancreas|3/24|
|peripheral nervous system|2/16|
|plasma cell|3/15|
|prostate|0/1|
|skin|7/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|4/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1254
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.54 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCRC2 Expression in NALM6 Cells: 7.54'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>