======= UQCRQ =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UQCRQ
  * **<color #00a2e8>Official Name</color>**: ubiquinol-cytochrome c reductase complex III subunit VII
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27089|27089]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O14949|O14949]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UQCRQ&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UQCRQ|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612080|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a ubiquinone-binding protein of low molecular mass. This protein is a small core-associated protein and a subunit of ubiquinol-cytochrome c reductase complex III, which is part of the mitochondrial respiratory chain. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  This is a component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is part of the mitochondrial respiratory chain. This subunit, together with cytochrome b, binds to ubiquinone.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UcrQ|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|subthalamus development|
|pyramidal neuron development|
|pyramidal neuron differentiation|
|ubiquinol-cytochrome-c reductase activity|
|pons development|
|thalamus development|
|mitochondrial respiratory chain complex III|
|mitochondrial electron transport, ubiquinol to cytochrome c|
|hypothalamus development|
|cerebellar Purkinje cell layer development|
|forebrain neuron development|
|cerebellar cortex development|
|forebrain neuron differentiation|
|forebrain generation of neurons|
|diencephalon development|
|central nervous system neuron development|
|hippocampus development|
|midbrain development|
|mitochondrial ATP synthesis coupled electron transport|
|ATP synthesis coupled electron transport|
|cerebellum development|
|limbic system development|
|respiratory electron transport chain|
|metencephalon development|
|oxidative phosphorylation|
|hindbrain development|
|cellular respiration|
|pallium development|
|central nervous system neuron differentiation|
|electron transport chain|
|ATP metabolic process|
|energy derivation by oxidation of organic compounds|
|telencephalon development|
|forebrain development|
|mitochondrial inner membrane|
|generation of precursor metabolites and energy|
|brain development|
|head development|
|neuron development|
|oxidation-reduction process|
|central nervous system development|
|neuron differentiation|
|mitochondrion|
|phosphorylation|
|generation of neurons|
|neurogenesis|
|cell development|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|-1.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.71|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.72|
|[[:results:exp65|Mubritinib 0.2μM R02 exp65]]|1.75|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.83|
|[[:results:exp472|CI-1040 9.5μM R08 exp472]]|2.02|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|2.25|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|3.43|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:m:mrps34|MRPS34]]|0.527|
|[[:human genes:m:mrps26|MRPS26]]|0.51|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.497|
|[[:human genes:r:rpusd4|RPUSD4]]|0.496|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.492|
|[[:human genes:c:cox16|COX16]]|0.49|
|[[:human genes:m:mtpap|MTPAP]]|0.483|
|[[:human genes:m:mrpl23|MRPL23]]|0.482|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.481|
|[[:human genes:t:tars2|TARS2]]|0.48|
|[[:human genes:m:mrps14|MRPS14]]|0.474|
|[[:human genes:b:bcs1l|BCS1L]]|0.472|
|[[:human genes:y:yars2|YARS2]]|0.472|
|[[:human genes:m:mrpl21|MRPL21]]|0.467|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.461|
|[[:human genes:s:sars2|SARS2]]|0.461|
|[[:human genes:m:mrpl47|MRPL47]]|0.458|
|[[:human genes:c:cox7b|COX7B]]|0.455|
|[[:human genes:t:triap1|TRIAP1]]|0.452|
|[[:human genes:t:tufm|TUFM]]|0.448|
|[[:human genes:u:uqcc2|UQCC2]]|0.443|
|[[:human genes:v:vars2|VARS2]]|0.441|
|[[:human genes:c:c12orf65|C12orf65]]|0.44|
|[[:human genes:a:atp5d|ATP5D]]|0.44|
|[[:human genes:u:uqcr10|UQCR10]]|0.435|
|[[:human genes:h:hccs|HCCS]]|0.431|
|[[:human genes:d:dap3|DAP3]]|0.431|
|[[:human genes:s:sco2|SCO2]]|0.431|
|[[:human genes:m:mrps21|MRPS21]]|0.431|
|[[:human genes:d:dars2|DARS2]]|0.43|
|[[:human genes:c:cox17|COX17]]|0.429|
|[[:human genes:m:mrps9|MRPS9]]|0.429|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.429|
|[[:human genes:m:mrps18a|MRPS18A]]|0.425|
|[[:human genes:u:uap1|UAP1]]|0.424|
|[[:human genes:s:slc25a26|SLC25A26]]|0.422|
|[[:human genes:p:pdss1|PDSS1]]|0.421|
|[[:human genes:m:mrps6|MRPS6]]|0.421|
|[[:human genes:s:selrc1|SELRC1]]|0.419|
|[[:human genes:r:rars2|RARS2]]|0.417|
|[[:human genes:c:chchd4|CHCHD4]]|0.417|
|[[:human genes:m:mrps2|MRPS2]]|0.416|
|[[:human genes:m:mrpl15|MRPL15]]|0.414|
|[[:human genes:m:mrps16|MRPS16]]|0.412|
|[[:human genes:m:mrps5|MRPS5]]|0.412|
|[[:human genes:s:sdha|SDHA]]|0.41|
|[[:human genes:m:mrpl34|MRPL34]]|0.41|
|[[:human genes:m:mrps10|MRPS10]]|0.409|
|[[:human genes:r:rbfa|RBFA]]|0.407|
|[[:human genes:d:dhrsx|DHRSX]]|0.406|
|[[:human genes:f:fastkd5|FASTKD5]]|0.406|
|[[:human genes:c:cox6b1|COX6B1]]|0.403|
|[[:human genes:f:fam195a|FAM195A]]|0.401|
|[[:human genes:a:atp5j|ATP5J]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 13/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|1/28|
|blood|1/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|2/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 3273
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.99 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UQCRQ Expression in NALM6 Cells: 5.99'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>