======= UROD =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UROD
  * **<color #00a2e8>Official Name</color>**: uroporphyrinogen decarboxylase
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7389|7389]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P06132|P06132]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UROD&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UROD|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/613521|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes an enzyme in the heme biosynthetic pathway. This enzyme is responsible for catalyzing the conversion of uroporphyrinogen to coproporphyrinogen through the removal of four carboxymethyl side chains. Mutations and deficiency in this enzyme are known to cause familial porphyria cutanea tarda and hepatoerythropoetic porphyria.[provided by RefSeq, Aug 2010]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|URO-D|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|uroporphyrinogen decarboxylase activity|
|protoporphyrinogen IX biosynthetic process|
|protoporphyrinogen IX metabolic process|
|heme biosynthetic process|
|porphyrin-containing compound biosynthetic process|
|tetrapyrrole biosynthetic process|
|heme metabolic process|
|porphyrin-containing compound metabolic process|
|pigment biosynthetic process|
|tetrapyrrole metabolic process|
|pigment metabolic process|
|cofactor biosynthetic process|
|cofactor metabolic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|organic cyclic compound biosynthetic process|
|organonitrogen compound biosynthetic process|
|cellular nitrogen compound biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp48|Mubritinib 0.2μM R01 exp48]]|-2.53|
|[[:results:exp46|HMS-I1 1μM R01 exp46]]|-2.33|
|[[:results:exp519|RS-1 10μM R08 exp519]]|-2.29|
|[[:results:exp502|Milciclib 2μM R08 exp502]]|-2.28|
|[[:results:exp450|Artemisinin 50μM R08 exp450]]|-2.2|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|-2.15|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|-2.15|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|-2.02|
|[[:results:exp112|S-DABN 8μM R03 exp112]]|-1.92|
|[[:results:exp460|BML-284 0.09μM R08 exp460]]|-1.86|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.86|
|[[:results:exp1|5-Fluorouracil 2μM R00 exp1]]|-1.84|
|[[:results:exp274|Citral 50μM R06 exp274]]|-1.83|
|[[:results:exp59|UMK57 1μM R01 exp59]]|-1.83|
|[[:results:exp54|Taxol 0.002μM R01 exp54]]|-1.82|
|[[:results:exp60|Vinblastine 0.002μM R01 exp60]]|-1.82|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|-1.8|
|[[:results:exp335|Aminopterin 0.005μM R07 exp335]]|-1.79|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.79|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|-1.77|
|[[:results:exp114|A-196 10μM R03 exp114]]|-1.75|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|-1.75|
|[[:results:exp539|42°C R08 exp539]]|-1.73|
|[[:results:exp58|UM131593 0.1μM R01 exp58]]|-1.73|
|[[:results:exp359|FK-506 30μM R07 exp359]]|1.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.522|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 135/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|6/28|
|blood|10/28|
|bone|3/26|
|breast|6/33|
|central nervous system|2/56|
|cervix|0/4|
|colorectal|4/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|5/16|
|kidney|2/21|
|liver|1/20|
|lung|18/75|
|lymphocyte|10/16|
|ovary|3/26|
|pancreas|6/24|
|peripheral nervous system|1/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|2/24|
|soft tissue|2/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 80
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.02 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UROD Expression in NALM6 Cells: 5.02'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>