======= USP14 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP14
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 14
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9097|9097]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P54578|P54578]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP14&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP14|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/607274|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Proteasome-associated deubiquitinase which releases ubiquitin from the proteasome targeted ubiquitinated proteins. Ensures the regeneration of ubiquitin at the proteasome. Is a reversibly associated subunit of the proteasome and a large fraction of proteasome-free protein exists within the cell. Required for the degradation of the chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Serves also as a physiological inhibitor of endoplasmic reticulum-associated degradation (ERAD) under the non-stressed condition by inhibiting the degradation of unfolded endoplasmic reticulum proteins via interaction with ERN1. Indispensable for synaptic development and function at neuromuscular junctions (NMJs). Plays a role in the innate immune defense against viruses by stabilizing the viral DNA sensor CGAS and thus inhibiting its autophagic degradation. {ECO:0000269|PubMed:18162577, ECO:0000269|PubMed:19106094, ECO:0000269|PubMed:19135427, ECO:0000269|PubMed:27666593}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|tRNA guanylyltransferase activity|
|negative regulation of ER-associated ubiquitin-dependent protein catabolic process|
|regulation of ER-associated ubiquitin-dependent protein catabolic process|
|negative regulation of ERAD pathway|
|tRNA 5-end processing|
|proteasome binding|
|ncRNA 5-end processing|
|RNA 5-end processing|
|regulation of ERAD pathway|
|negative regulation of proteasomal ubiquitin-dependent protein catabolic process|
|endopeptidase inhibitor activity|
|negative regulation of response to endoplasmic reticulum stress|
|negative regulation of ubiquitin-dependent protein catabolic process|
|thiol-dependent ubiquitinyl hydrolase activity|
|proteasome complex|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of proteasomal ubiquitin-dependent protein catabolic process|
|tRNA processing|
|negative regulation of protein catabolic process|
|regulation of ubiquitin-dependent protein catabolic process|
|regulation of proteasomal protein catabolic process|
|tRNA metabolic process|
|regulation of chemotaxis|
|regulation of proteolysis involved in cellular protein catabolic process|
|negative regulation of endopeptidase activity|
|regulation of cellular protein catabolic process|
|cytoplasmic vesicle|
|negative regulation of cellular catabolic process|
|negative regulation of peptidase activity|
|synapse|
|protein deubiquitination|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|ncRNA processing|
|regulation of endopeptidase activity|
|anterograde trans-synaptic signaling|
|chemical synaptic transmission|
|trans-synaptic signaling|
|regulation of peptidase activity|
|negative regulation of hydrolase activity|
|synaptic signaling|
|ncRNA metabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cell surface|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|innate immune response|
|negative regulation of catalytic activity|
|regulation of cellular catabolic process|
|RNA processing|
|cellular macromolecule catabolic process|
|defense response to other organism|
|regulation of locomotion|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|regulation of response to external stimulus|
|negative regulation of protein metabolic process|
|cell-cell signaling|
|negative regulation of molecular function|
|proteolysis|
|regulation of hydrolase activity|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|negative regulation of response to stimulus|
|RNA metabolic process|
|organic substance catabolic process|
|cellular catabolic process|
|immune response|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|-5.63|
|[[:results:exp75|MK-1775 0.32μM R02 exp75]]|1.72|
|[[:results:exp134|MS023 2μM R03 exp134]]|1.75|
|[[:results:exp64|Nocodazole 0.2μM R02 exp64]]|1.75|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|1.86|
|[[:results:exp478|Doxorubicin 0.02μM R08 exp478]]|1.93|
|[[:results:exp19|Etoposide 1μM R00 exp19]]|1.95|
|[[:results:exp85|UM0129480 7μM R02 exp85]]|1.95|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|1.98|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.15|
|[[:results:exp412|THZ531 0.11 to 0.125 to 0.35μM on day4 then day6 R07 exp412]]|2.27|
|[[:results:exp485|GSK626616 14μM R08 exp485]]|2.34|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|2.35|
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|2.7|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|2.87|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 5/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|2/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|1/75|
|lymphocyte|0/16|
|ovary|1/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|1/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 13746
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.17 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP14 Expression in NALM6 Cells: 7.17'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>