======= USP25 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP25
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 25
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=29761|29761]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9UHP3|Q9UHP3]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP25&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP25|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/604736|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme that hydrolyzes ubiquitin moieties conjugated to substrates and thus, functions to process newly synthesized Ubiquitin, to recycle ubiquitin molecules or to edit polyubiquitin chains and prevents proteasomal degradation of substrates. Hydrolyzes both 'Lys-48'- and 'Lys-63'-linked tetraubiquitin chains.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|ubiquitin-like protein-specific protease activity|
|negative regulation of ERAD pathway|
|regulation of ERAD pathway|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|negative regulation of response to endoplasmic reticulum stress|
|thiol-dependent ubiquitinyl hydrolase activity|
|negative regulation of proteasomal protein catabolic process|
|negative regulation of proteolysis involved in cellular protein catabolic process|
|ATPase binding|
|ubiquitin binding|
|peptidase activity|
|regulation of response to endoplasmic reticulum stress|
|negative regulation of cellular protein catabolic process|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|negative regulation of protein catabolic process|
|regulation of proteasomal protein catabolic process|
|regulation of proteolysis involved in cellular protein catabolic process|
|regulation of cellular protein catabolic process|
|negative regulation of cellular catabolic process|
|protein deubiquitination|
|regulation of protein stability|
|ubiquitin protein ligase binding|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|negative regulation of proteolysis|
|regulation of protein catabolic process|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|protein catabolic process|
|regulation of proteolysis|
|regulation of cellular response to stress|
|regulation of cellular catabolic process|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|endoplasmic reticulum|
|negative regulation of cellular protein metabolic process|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|negative regulation of protein metabolic process|
|proteolysis|
|regulation of response to stress|
|negative regulation of response to stimulus|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp191|Hypoxia 5%O2 R04 exp191]]|-1.82|
|[[:results:exp102|Nifuroxazide 5μM R03 exp102]]|-1.7|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|1.74|
|[[:results:exp527|Tanespimycin 14μM R08 exp527]]|1.78|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.79|
|[[:results:exp175|3-Bromopyruvate 7μM R04 exp175]]|1.82|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|1.84|
|[[:results:exp68|Clomiphene 4.4μM R02 exp68]]|2.03|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hars|HARS]]|0.602|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 12141
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.84 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP25 Expression in NALM6 Cells: 5.84'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>