======= USP27X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP27X
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 27 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=389856|389856]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/A6NNY8|A6NNY8]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP27X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP27X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300975|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a member of the peptidase protein family. The encoded protein functions as a deubiquitinase that is involved in upregulation of the pro-apoptotic Bim protein. This protein may act as a tumor suppressor by increasing levels of Bim to counteract anti-apoptotic signals in cancer cells. Mutations in this gene have been associated with X-linked cognitive disability. [provided by RefSeq, Dec 2016]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinase that can reduce the levels of BCL2L11/BIM ubiquitination and stabilize BCL2L11 in response to the RAF-MAPK- degradation signal. By acting on BCL2L11 levels, may counteract the anti-apoptotic effects of MAPK activity. {ECO:0000250|UniProtKB:Q8CEG8}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Lys63-specific deubiquitinase activity|
|Lys48-specific deubiquitinase activity|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|thiol-dependent ubiquitin-specific protease activity|
|protein stabilization|
|protein deubiquitination|
|regulation of protein stability|
|protein modification by small protein removal|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|protein catabolic process|
|positive regulation of cell death|
|cellular macromolecule catabolic process|
|protein modification by small protein conjugation or removal|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|proteolysis|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp230|Epigallocatechin gallate 20μM R05 exp230]]|-2.23|
|[[:results:exp514|Phorbol-12-myristate-13-acetate 0.57μM R08 exp514]]|-2.21|
|[[:results:exp525|Sulforaphane 9μM R08 exp525]]|-1.96|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|-1.83|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|-1.73|
|[[:results:exp164|Q15 1 to 2μM on day4 R04 exp164]]|-1.72|
|[[:results:exp316|Geldanamycin 0.015 to 0.025μM on day4 R07 exp316]]|1.72|
|[[:results:exp336|Asunaprenir 3μM R07 exp336]]|1.74|
|[[:results:exp536|Vitamin-D3 40μM R08 exp536]]|1.77|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.82|
|[[:results:exp222|Betulinic acid 10 to 15μM on day4 R05 exp222]]|1.9|
|[[:results:exp413|THZ531 0.11 to 0.175μM on day4 R07 exp413]]|1.96|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|1.98|
|[[:results:exp360|Genistein 15μM R07 exp360]]|1.99|
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|2.03|
|[[:results:exp421|VHL-ligand-1 20μM R07 exp421]]|2.03|
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|2.04|
|[[:results:exp417|Tubastatin-A 2.5μM R07 exp417]]|2.09|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|2.15|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|2.2|
|[[:results:exp486|Heregulin-B 44ng/ml R08 exp486]]|2.22|
|[[:results:exp365|I-BRD9 4μM R07 exp365]]|2.23|
|[[:results:exp15|Cycloheximide 0.2μM R00 exp15]]|2.3|
|[[:results:exp392|PT-1 25μM R07 exp392]]|2.37|
|[[:results:exp311|2-Methoxyestradiol 0.55 to 0.75μM  on day4 R07 exp311]]|2.43|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|2.52|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|2.53|
|[[:results:exp496|Lead acetate 990μM R08 exp496]]|2.55|
|[[:results:exp456|Benzoate 20000μM R08 exp456]]|2.72|
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|2.97|
|[[:results:exp211|AICAR 240μM R05 exp211]]|3.22|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/26|
|bone|0/26|
|breast|0/30|
|central nervous system|0/49|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/11|
|fibroblast|0/1|
|gastric|0/14|
|kidney|0/18|
|liver|0/19|
|lung|0/72|
|lymphocyte|0/16|
|ovary|0/25|
|pancreas|0/22|
|peripheral nervous system|0/15|
|plasma cell|0/12|
|prostate|0/1|
|skin|0/20|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/28|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 10925
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 1.55 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP27X Expression in NALM6 Cells: 1.55'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>