======= USP33 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP33
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 33
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=23032|23032]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q8TEY7|Q8TEY7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP33&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP33|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/615146|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G-protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta- arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. {ECO:0000269|PubMed:12865408, ECO:0000269|PubMed:19363159, ECO:0000269|PubMed:19424180, ECO:0000269|PubMed:23486064}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|zf-UBP|
|DUSP|
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|VCB complex|
|Ral GTPase binding|
|centrosome duplication|
|protein K63-linked deubiquitination|
|protein K48-linked deubiquitination|
|thiol-dependent ubiquitinyl hydrolase activity|
|G protein-coupled receptor binding|
|cell body|
|ubiquitin binding|
|centrosome cycle|
|cysteine-type endopeptidase activity|
|microtubule organizing center organization|
|positive regulation of protein binding|
|negative regulation of protein binding|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of G protein-coupled receptor signaling pathway|
|cellular response to starvation|
|negative regulation of binding|
|protein stabilization|
|positive regulation of binding|
|response to starvation|
|regulation of protein binding|
|cellular response to nutrient levels|
|axon guidance|
|neuron projection guidance|
|cellular response to extracellular stimulus|
|protein deubiquitination|
|regulation of protein stability|
|protein modification by small protein removal|
|regulation of autophagy|
|cellular response to external stimulus|
|axonogenesis|
|regulation of binding|
|axon development|
|focal adhesion|
|cell morphogenesis involved in neuron differentiation|
|microtubule cytoskeleton organization|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|centrosome|
|response to nutrient levels|
|cell part morphogenesis|
|ubiquitin-dependent protein catabolic process|
|response to extracellular stimulus|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|chemotaxis|
|taxis|
|endocytosis|
|cell morphogenesis involved in differentiation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|neuron projection development|
|microtubule-based process|
|import into cell|
|protein catabolic process|
|perinuclear region of cytoplasm|
|cell morphogenesis|
|neuron development|
|cellular component morphogenesis|
|regulation of cellular catabolic process|
|zinc ion binding|
|cellular macromolecule catabolic process|
|cell migration|
|Golgi apparatus|
|protein modification by small protein conjugation or removal|
|regulation of catabolic process|
|cell cycle process|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|cytoskeleton organization|
|plasma membrane bounded cell projection organization|
|negative regulation of molecular function|
|cell projection organization|
|proteolysis|
|locomotion|
|cell cycle|
|generation of neurons|
|movement of cell or subcellular component|
|neurogenesis|
|cell development|
|cellular response to stress|
|organic substance catabolic process|
|positive regulation of molecular function|
|cellular catabolic process|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp83|Trametinib 10μM R02 exp83]]|-2.01|
|[[:results:exp512|Olaparib 4μM R08 exp512]]|-1.93|
|[[:results:exp218|A-395 10μM R05 exp218]]|-1.8|
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.74|
|[[:results:exp23|Nocodazole 0.02μM R00 exp23]]|1.76|
|[[:results:exp501|Methotrexate 0.01μM R08 exp501]]|1.88|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 15476
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.24 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP33 Expression in NALM6 Cells: 6.24'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>