======= USP36 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP36
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 36
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57602|57602]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9P275|Q9P275]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP36&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP36|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612543|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  May be required for maintaining multiple types of adult stem cells. May function as a transcriptional repressor by continually deubiquiting histone H2B at the promoters of genes critical for cellular differentiation, thereby preventing histone H3 'Lys-4' trimethylation (H3K4) (By similarity). {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|nucleolus organization|
|regulation of rRNA processing|
|regulation of ribosome biogenesis|
|histone deubiquitination|
|positive regulation of protein targeting to mitochondrion|
|negative regulation of macroautophagy|
|regulation of autophagy of mitochondrion|
|regulation of protein targeting to mitochondrion|
|positive regulation of establishment of protein localization to mitochondrion|
|regulation of establishment of protein localization to mitochondrion|
|regulation of protein targeting|
|negative regulation of autophagy|
|cysteine-type endopeptidase activity|
|thiol-dependent ubiquitin-specific protease activity|
|positive regulation of mitochondrion organization|
|nucleus organization|
|positive regulation of intracellular protein transport|
|regulation of macroautophagy|
|protein stabilization|
|regulation of mitochondrion organization|
|positive regulation of intracellular transport|
|regulation of intracellular protein transport|
|negative regulation of cellular catabolic process|
|protein deubiquitination|
|regulation of protein stability|
|protein modification by small protein removal|
|negative regulation of catabolic process|
|positive regulation of cellular protein localization|
|regulation of autophagy|
|regulation of intracellular transport|
|histone modification|
|covalent chromatin modification|
|nuclear speck|
|positive regulation of protein transport|
|positive regulation of establishment of protein localization|
|ubiquitin-dependent protein catabolic process|
|modification-dependent protein catabolic process|
|regulation of cellular protein localization|
|modification-dependent macromolecule catabolic process|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|positive regulation of organelle organization|
|protein catabolic process|
|chromatin organization|
|regulation of protein transport|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of cellular catabolic process|
|nucleolus|
|cellular macromolecule catabolic process|
|regulation of cellular localization|
|regulation of cellular component biogenesis|
|protein modification by small protein conjugation or removal|
|positive regulation of transport|
|regulation of catabolic process|
|regulation of protein localization|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|chromosome organization|
|positive regulation of cellular component organization|
|proteolysis|
|regulation of organelle organization|
|RNA binding|
|regulation of apoptotic process|
|regulation of programmed cell death|
|regulation of cell death|
|organic substance catabolic process|
|cellular catabolic process|
|regulation of transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp515|PU-H71 1μM R08 exp515]]|-1.91|
|[[:results:exp13|Chloramphenicol 20μM R00 exp13]]|1.72|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|1.73|
|[[:results:exp5|Alpha-Amanitin 0.5μM R00 exp5]]|1.79|
|[[:results:exp21|MLN-4924 0.2μM R00 exp21]]|1.8|
|[[:results:exp27|Pimelic-diphenylamide-106 0.5μM R00 exp27]]|1.87|
|[[:results:exp32|Rifampicin 10μM R00 exp32]]|1.94|
|[[:results:exp38|Wortmannin 5μM R00 exp38]]|2.32|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:n:nupl1|NUPL1]]|0.453|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.451|
|[[:human genes:k:kctd17|KCTD17]]|0.442|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.44|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.44|
|[[:human genes:t:terf2|TERF2]]|0.437|
|[[:human genes:r:rps12|RPS12]]|0.432|
|[[:human genes:p:psmd1|PSMD1]]|0.431|
|[[:human genes:c:chd4|CHD4]]|0.424|
|[[:human genes:d:dtl|DTL]]|0.421|
|[[:human genes:p:psmd11|PSMD11]]|0.419|
|[[:human genes:p:plk4|PLK4]]|0.418|
|[[:human genes:s:shpk|SHPK]]|0.416|
|[[:human genes:c:ccdc64b|CCDC64B]]|0.415|
|[[:human genes:v:vasn|VASN]]|0.411|
|[[:human genes:u:ubap1|UBAP1]]|0.405|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 721/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|26/28|
|blood|27/28|
|bone|26/26|
|breast|31/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|16/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|21/21|
|liver|20/20|
|lung|73/75|
|lymphocyte|14/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|15/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|24/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1306
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.98 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP36 Expression in NALM6 Cells: 6.98'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>