======= USP9X =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USP9X
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase 9 X-linked
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=8239|8239]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q93008|Q93008]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USP9X&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USP9X|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/300072|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene is a member of the peptidase C19 family and encodes a protein that is similar to ubiquitin-specific proteases. Though this gene is located on the X chromosome, it escapes X-inactivation. Mutations in this gene have been associated with Turner syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Deubiquitinase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. May therefore play an important regulatory role at the level of protein turnover by preventing degradation of proteins through the removal of conjugated ubiquitin. Essential component of TGF-beta/BMP signaling cascade. Regulates chromosome alignment and segregation in mitosis by regulating the localization of BIRC5/survivin to mitotic centromeres. Specifically hydrolyzes both 'Lys-29'- and 'Lys-33'-linked polyubiquitins chains. Specifically deubiquitinates monoubiquitinated SMAD4, opposing the activity of E3 ubiquitin-protein ligase TRIM33. Involved in axonal growth and neuronal cell migration. {ECO:0000269|PubMed:16322459, ECO:0000269|PubMed:18254724, ECO:0000269|PubMed:19135894, ECO:0000269|PubMed:24607389}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|UCH|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of DNA demethylation|
|ubiquitinyl hydrolase activity|
|regulation of DNA demethylation|
|protein deubiquitination involved in ubiquitin-dependent protein catabolic process|
|co-SMAD binding|
|Lys48-specific deubiquitinase activity|
|cysteine-type peptidase activity|
|protein K48-linked deubiquitination|
|axon extension|
|thiol-dependent ubiquitinyl hydrolase activity|
|neuron projection extension|
|protein targeting to peroxisome|
|protein localization to peroxisome|
|establishment of protein localization to peroxisome|
|peroxisomal transport|
|peroxisome organization|
|developmental cell growth|
|cell growth|
|BMP signaling pathway|
|cysteine-type endopeptidase activity|
|transforming growth factor beta receptor signaling pathway|
|cellular response to BMP stimulus|
|response to BMP|
|thiol-dependent ubiquitin-specific protease activity|
|regulation of circadian rhythm|
|developmental growth involved in morphogenesis|
|neuron migration|
|growth cone|
|female gamete generation|
|cellular response to transforming growth factor beta stimulus|
|response to transforming growth factor beta|
|protein stabilization|
|positive regulation of DNA metabolic process|
|transmembrane receptor protein serine/threonine kinase signaling pathway|
|chromosome segregation|
|rhythmic process|
|protein deubiquitination|
|regulation of protein stability|
|protein modification by small protein removal|
|regulation of DNA metabolic process|
|protein targeting|
|axonogenesis|
|developmental growth|
|growth|
|axon development|
|establishment of protein localization to organelle|
|cell morphogenesis involved in neuron differentiation|
|neuron projection morphogenesis|
|plasma membrane bounded cell projection morphogenesis|
|cell projection morphogenesis|
|cell division|
|cellular response to growth factor stimulus|
|cell part morphogenesis|
|ubiquitin-dependent protein catabolic process|
|response to growth factor|
|modification-dependent protein catabolic process|
|modification-dependent macromolecule catabolic process|
|cell morphogenesis involved in differentiation|
|proteolysis involved in cellular protein catabolic process|
|cellular protein catabolic process|
|neuron projection development|
|protein catabolic process|
|protein ubiquitination|
|gamete generation|
|enzyme linked receptor protein signaling pathway|
|cell morphogenesis|
|protein localization to organelle|
|protein modification by small protein conjugation|
|neuron development|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|sexual reproduction|
|multicellular organism reproduction|
|negative regulation of transcription by RNA polymerase II|
|cellular macromolecule catabolic process|
|cell migration|
|protein modification by small protein conjugation or removal|
|intracellular protein transport|
|multi-organism reproductive process|
|neuron differentiation|
|macromolecule catabolic process|
|organonitrogen compound catabolic process|
|cell motility|
|localization of cell|
|plasma membrane bounded cell projection organization|
|cell projection organization|
|negative regulation of transcription, DNA-templated|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|proteolysis|
|locomotion|
|negative regulation of RNA metabolic process|
|cell cycle|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|negative regulation of nucleobase-containing compound metabolic process|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|protein transport|
|negative regulation of cellular biosynthetic process|
|intracellular transport|
|generation of neurons|
|peptide transport|
|negative regulation of biosynthetic process|
|movement of cell or subcellular component|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|neurogenesis|
|cell development|
|negative regulation of gene expression|
|organic substance catabolic process|
|cellular catabolic process|
|establishment of localization in cell|
|nitrogen compound transport|
|positive regulation of nucleobase-containing compound metabolic process|
|membrane|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp468|CB-5083 0.4μM R08 exp468]]|-2.15|
|[[:results:exp330|5-Azacytidine 2μM R07 exp330]]|-1.97|
|[[:results:exp116|AICAR 240μM R03 exp116]]|-1.96|
|[[:results:exp443|SNS-032 15μM R08 exp443]]|-1.96|
|[[:results:exp147|Resveratrol 16μM R03 exp147]]|-1.92|
|[[:results:exp539|42°C R08 exp539]]|-1.89|
|[[:results:exp357|Dorsomorphin 5μM R07 exp357]]|-1.82|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|-1.71|
|[[:results:exp198|Etoposide 0.1μM R05 exp198]]|1.98|
|[[:results:exp169|BH1 1μM R04 exp169]]|2.1|
|[[:results:exp90|WYE-354 6μM R02 exp90]]|2.1|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|2.18|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:r:ranbp1|RANBP1]]|0.421|
|[[:human genes:r:rqcd1|RQCD1]]|0.403|
|[[:human genes:b:bcl2l1|BCL2L1]]|0.401|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 339/694
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|12/28|
|blood|9/26|
|bone|13/26|
|breast|17/30|
|central nervous system|24/49|
|cervix|2/4|
|colorectal|7/17|
|esophagus|6/11|
|fibroblast|0/1|
|gastric|4/14|
|kidney|7/18|
|liver|9/19|
|lung|34/72|
|lymphocyte|9/16|
|ovary|15/25|
|pancreas|4/22|
|peripheral nervous system|6/15|
|plasma cell|5/12|
|prostate|0/1|
|skin|14/20|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|10/22|
|urinary tract|12/28|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1250
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 7.64 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USP9X Expression in NALM6 Cells: 7.64'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>