======= USPL1 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: USPL1
  * **<color #00a2e8>Official Name</color>**: ubiquitin specific peptidase like 1
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=10208|10208]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5W0Q7|Q5W0Q7]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=USPL1&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20USPL1|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/617470|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SUMO-specific isopeptidase involved in protein desumoylation. Specifically binds SUMO proteins with a higher affinity for SUMO2 and SUMO3 which it cleaves more efficiently. Also able to process full-length SUMO proteins to their mature forms (PubMed:22878415). Plays a key role in RNA polymerase-II- mediated snRNA transcription in the Cajal bodies (PubMed:24413172). Is a component of complexes that can bind to U snRNA genes (PubMed:24413172). {ECO:0000269|PubMed:22878415, ECO:0000269|PubMed:24413172}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|SUMO-specific isopeptidase activity|
|Cajal body organization|
|protein desumoylation|
|SUMO binding|
|nuclear body organization|
|Cajal body|
|snRNA transcription|
|ubiquitin binding|
|ncRNA transcription|
|nucleus organization|
|protein modification by small protein removal|
|peptidyl-lysine modification|
|cell population proliferation|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|RNA biosynthetic process|
|peptidyl-amino acid modification|
|protein modification by small protein conjugation or removal|
|nucleobase-containing compound biosynthetic process|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|proteolysis|
|organic cyclic compound biosynthetic process|
|extracellular space|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp131|L-74142 5μM R03 exp131]]|1.7|
|[[:results:exp51|Nifuroxazide 1μM R01 exp51]]|1.75|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:h:hgc6.3|HGC6.3]]|0.543|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.451|
|[[:human genes:n:nol12|NOL12]]|0.436|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.432|
|[[:human genes:o:ogfr|OGFR]]|0.413|
|[[:human genes:n:npipb5|NPIPB5]]|0.413|
|[[:human genes:n:narfl|NARFL]]|0.412|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.406|
|[[:human genes:r:rrn3|RRN3]]|0.405|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.404|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 408/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|20/28|
|blood|13/28|
|bone|9/26|
|breast|13/33|
|central nervous system|36/56|
|cervix|4/4|
|colorectal|7/17|
|esophagus|7/13|
|fibroblast|1/1|
|gastric|10/16|
|kidney|10/21|
|liver|13/20|
|lung|45/75|
|lymphocyte|5/16|
|ovary|16/26|
|pancreas|13/24|
|peripheral nervous system|9/16|
|plasma cell|10/15|
|prostate|0/1|
|skin|13/24|
|soft tissue|5/9|
|thyroid|1/2|
|upper aerodigestive|12/22|
|urinary tract|16/29|
|uterus|5/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1964
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.74 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='USPL1 Expression in NALM6 Cells: 5.74'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>