======= UTP18 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTP18
  * **<color #00a2e8>Official Name</color>**: UTP18 small subunit processome component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=51096|51096]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9Y5J1|Q9Y5J1]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UTP18&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UTP18|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612816|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in nucleolar processing of pre-18S ribosomal RNA. {ECO:0000250}.

<button type='default' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
No Pfam Domain information is available for this gene.
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|Pwp2p-containing subcomplex of 90S preribosome|
|small-subunit processome|
|rRNA processing|
|rRNA metabolic process|
|nuclear membrane|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp539|42°C R08 exp539]]|-1.77|
|[[:results:exp294|Nutlin-3A 1.6μM R06 exp294]]|-1.73|
|[[:results:exp133|MKC9989 10μM R03 exp133]]|1.87|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|1.92|
|[[:results:exp273|Cisplatin 0.35μM R06 exp273]]|1.94|
|[[:results:exp238|Parthenolide 2.5μM R05 exp238]]|1.95|
|[[:results:exp190|Vincristine 0.0005μM R04 exp190]]|2|
|[[:results:exp176|Apcin 50 to 100μM on day4 R04 exp176]]|2.26|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:polr2j3|POLR2J3]]|0.462|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.442|
|[[:human genes:d:ddtl|DDTL]]|0.438|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.427|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.42|
|[[:human genes:a:ankle1|ANKLE1]]|0.411|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 145/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|8/28|
|blood|1/28|
|bone|6/26|
|breast|6/33|
|central nervous system|16/56|
|cervix|0/4|
|colorectal|3/17|
|esophagus|4/13|
|fibroblast|0/1|
|gastric|4/16|
|kidney|7/21|
|liver|2/20|
|lung|15/75|
|lymphocyte|2/16|
|ovary|2/26|
|pancreas|2/24|
|peripheral nervous system|2/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|5/24|
|soft tissue|4/9|
|thyroid|1/2|
|upper aerodigestive|3/22|
|urinary tract|5/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 1910
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.29 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UTP18 Expression in NALM6 Cells: 6.29'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>