======= UTP20 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTP20
  * **<color #00a2e8>Official Name</color>**: UTP20 small subunit processome component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=27340|27340]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/O75691|O75691]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UTP20&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UTP20|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612822|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in 18S pre-rRNA processing. Associates with U3 snoRNA. {ECO:0000269|PubMed:17498821}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|DRIM|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|rRNA 5-end processing|
|endonucleolytic cleavage to generate mature 5-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|90S preribosome|
|endonucleolytic cleavage involved in rRNA processing|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|preribosome, small subunit precursor|
|ncRNA 5-end processing|
|RNA 5-end processing|
|cleavage involved in rRNA processing|
|maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|maturation of 5.8S rRNA|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|negative regulation of cell population proliferation|
|nucleolus|
|RNA processing|
|RNA binding|
|regulation of cell population proliferation|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|-1.77|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.7|
|[[:results:exp347|Cyclosporin-A 0.8μM R07 exp347]]|1.71|
|[[:results:exp185|L-BMAA 500 to 750μM on day4 R04 exp185]]|1.71|
|[[:results:exp241|QNZ 0.01μM R05 exp241]]|1.71|
|[[:results:exp326|CCT251545 20μM R07 exp326]]|1.72|
|[[:results:exp150|SGC0649 7μM R03 exp150]]|1.72|
|[[:results:exp342|Calcium Ionophore 0.4μM R07 exp342]]|1.75|
|[[:results:exp351|Dexamethasone 0.006μM R07 exp351]]|1.75|
|[[:results:exp243|S-trityl-L-cysteine 0.5μM R05 exp243]]|1.76|
|[[:results:exp480|ETC-159 50μM R08 exp480]]|1.79|
|[[:results:exp115|A-366 10μM R03 exp115]]|1.94|
|[[:results:exp432|YM155 0.001μM R08 exp432]]|1.94|
|[[:results:exp107|UMK57 0.6μM R03 exp107]]|2|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.01|
|[[:results:exp425|Beta-Estradiol 0.55μM R07 exp425]]|2.11|
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|2.22|
|[[:results:exp318|ABT-702 5μM R07 exp318]]|2.27|
|[[:results:exp464|Calcipotriol 5μM R08 exp464]]|2.28|
|[[:results:exp114|A-196 10μM R03 exp114]]|2.32|
|[[:results:exp483|FTY720 3μM R08 exp483]]|2.32|
|[[:results:exp180|Dynasore 10μM R04 exp180]]|2.97|
|[[:results:exp239|PFI-2 4μM R05 exp239]]|3.3|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:p:psmb2|PSMB2]]|0.534|
|[[:human genes:r:rpl35|RPL35]]|0.522|
|[[:human genes:c:cdc45|CDC45]]|0.514|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.502|
|[[:human genes:p:psma6|PSMA6]]|0.496|
|[[:human genes:e:exosc9|EXOSC9]]|0.478|
|[[:human genes:t:tceb3c|TCEB3C]]|0.476|
|[[:human genes:w:wdr75|WDR75]]|0.473|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.472|
|[[:human genes:r:rps28|RPS28]]|0.465|
|[[:human genes:s:supt5h|SUPT5H]]|0.464|
|[[:human genes:d:dimt1|DIMT1]]|0.463|
|[[:human genes:r:rbbp5|RBBP5]]|0.462|
|[[:human genes:r:rps12|RPS12]]|0.462|
|[[:human genes:r:rps5|RPS5]]|0.461|
|[[:human genes:h:heatr1|HEATR1]]|0.458|
|[[:human genes:t:twistnb|TWISTNB]]|0.458|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.457|
|[[:human genes:p:prim1|PRIM1]]|0.452|
|[[:human genes:c:cbwd5|CBWD5]]|0.452|
|[[:human genes:d:dtl|DTL]]|0.45|
|[[:human genes:p:psmb4|PSMB4]]|0.45|
|[[:human genes:s:sf3a3|SF3A3]]|0.448|
|[[:human genes:l:lrr1|LRR1]]|0.444|
|[[:human genes:v:vasn|VASN]]|0.444|
|[[:human genes:r:rps2|RPS2]]|0.443|
|[[:human genes:f:fam160a1|FAM160A1]]|0.442|
|[[:human genes:a:akirin2|AKIRIN2]]|0.442|
|[[:human genes:r:rrp7a|RRP7A]]|0.442|
|[[:human genes:o:ogfr|OGFR]]|0.441|
|[[:human genes:c:cbwd3|CBWD3]]|0.441|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.439|
|[[:human genes:s:snip1|SNIP1]]|0.437|
|[[:human genes:p:psmd1|PSMD1]]|0.437|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.436|
|[[:human genes:t:tfip11|TFIP11]]|0.436|
|[[:human genes:p:psma7|PSMA7]]|0.435|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.435|
|[[:human genes:n:npipb5|NPIPB5]]|0.431|
|[[:human genes:t:tyms|TYMS]]|0.431|
|[[:human genes:r:rps7|RPS7]]|0.43|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.427|
|[[:human genes:f:fbxw9|FBXW9]]|0.427|
|[[:human genes:p:psmd11|PSMD11]]|0.426|
|[[:human genes:n:nol12|NOL12]]|0.426|
|[[:human genes:c:cbwd6|CBWD6]]|0.426|
|[[:human genes:a:aatf|AATF]]|0.426|
|[[:human genes:c:ccna2|CCNA2]]|0.426|
|[[:human genes:a:arhgef35|ARHGEF35]]|0.425|
|[[:human genes:c:c14orf93|C14orf93]]|0.423|
|[[:human genes:b:bysl|BYSL]]|0.423|
|[[:human genes:p:polr2h|POLR2H]]|0.422|
|[[:human genes:g:golga6l4|GOLGA6L4]]|0.422|
|[[:human genes:u:utp3|UTP3]]|0.422|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.422|
|[[:human genes:i:iscu|ISCU]]|0.421|
|[[:human genes:c:copg1|COPG1]]|0.419|
|[[:human genes:n:nol10|NOL10]]|0.418|
|[[:human genes:t:trappc8|TRAPPC8]]|0.418|
|[[:human genes:g:golga8j|GOLGA8J]]|0.418|
|[[:human genes:p:pole|POLE]]|0.418|
|[[:human genes:v:vps28|VPS28]]|0.417|
|[[:human genes:c:copz1|COPZ1]]|0.415|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.414|
|[[:human genes:m:mcoln1|MCOLN1]]|0.414|
|[[:human genes:p:polr2j3|POLR2J3]]|0.414|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.414|
|[[:human genes:d:dock6|DOCK6]]|0.414|
|[[:human genes:p:polr2d|POLR2D]]|0.413|
|[[:human genes:c:cope|COPE]]|0.411|
|[[:human genes:m:myo1h|MYO1H]]|0.411|
|[[:human genes:l:loc643669|LOC643669]]|0.41|
|[[:human genes:r:rps11|RPS11]]|0.41|
|[[:human genes:o:or10g3|OR10G3]]|0.409|
|[[:human genes:r:rrp9|RRP9]]|0.409|
|[[:human genes:r:riok2|RIOK2]]|0.409|
|[[:human genes:p:psmb1|PSMB1]]|0.406|
|[[:human genes:c:chchd3|CHCHD3]]|0.406|
|[[:human genes:s:supt6h|SUPT6H]]|0.406|
|[[:human genes:t:timeless|TIMELESS]]|0.405|
|[[:human genes:c:cmya5|CMYA5]]|0.403|
|[[:human genes:p:pola2|POLA2]]|0.403|
|[[:human genes:m:med17|MED17]]|0.402|
|[[:human genes:u:ubl5|UBL5]]|0.401|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.4|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.4|
|[[:human genes:r:rpl37a|RPL37A]]|0.4|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 720/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|24/28|
|blood|27/28|
|bone|25/26|
|breast|32/33|
|central nervous system|56/56|
|cervix|4/4|
|colorectal|17/17|
|esophagus|13/13|
|fibroblast|1/1|
|gastric|16/16|
|kidney|20/21|
|liver|20/20|
|lung|74/75|
|lymphocyte|16/16|
|ovary|26/26|
|pancreas|24/24|
|peripheral nervous system|16/16|
|plasma cell|14/15|
|prostate|1/1|
|skin|23/24|
|soft tissue|9/9|
|thyroid|2/2|
|upper aerodigestive|22/22|
|urinary tract|29/29|
|uterus|4/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 341
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.68 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UTP20 Expression in NALM6 Cells: 6.68'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>