======= UTP23 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTP23
  * **<color #00a2e8>Official Name</color>**: UTP23 small subunit processome component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=84294|84294]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9BRU9|Q9BRU9]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UTP23&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UTP23|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**:  N/A

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Involved in rRNA-processing and ribosome biogenesis. {ECO:0000250}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Fcf1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|endonucleolytic cleavage in 5-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small ribosomal subunit rRNA binding|
|endonucleolytic cleavage involved in rRNA processing|
|endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|cleavage involved in rRNA processing|
|mRNA 5-UTR binding|
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|mRNA 3-UTR binding|
|RNA phosphodiester bond hydrolysis, endonucleolytic|
|RNA phosphodiester bond hydrolysis|
|rRNA processing|
|rRNA metabolic process|
|nucleic acid phosphodiester bond hydrolysis|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|nucleolus|
|RNA processing|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp494|Isoniazid 100μM R08 exp494]]|-1.87|
|[[:results:exp223|Cabazitaxel 0.001μM R05 exp223]]|-1.86|
|[[:results:exp319|ABT-702 5μM plus Dimethyloxaloylglycine 11μM R07 exp319]]|-1.72|
|[[:results:exp259|6-Thio-2-deoxyguanosine 2μM R06 exp259]]|1.73|
|[[:results:exp524|Staurosporine 0.02μM R08 exp524]]|1.76|
|[[:results:exp126|GSK461364A 0.1μM R03 exp126]]|1.8|
|[[:results:exp539|42°C R08 exp539]]|1.97|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:thg1l|THG1L]]|0.625|
|[[:human genes:g:gmppb|GMPPB]]|0.604|
|[[:human genes:p:pmm2|PMM2]]|0.604|
|[[:human genes:a:alg1|ALG1]]|0.581|
|[[:human genes:d:dpagt1|DPAGT1]]|0.574|
|[[:human genes:t:triap1|TRIAP1]]|0.573|
|[[:human genes:r:rpp21|RPP21]]|0.573|
|[[:human genes:d:ddx55|DDX55]]|0.557|
|[[:human genes:r:rptor|RPTOR]]|0.555|
|[[:human genes:p:pelo|PELO]]|0.555|
|[[:human genes:r:rnmt|RNMT]]|0.551|
|[[:human genes:a:adsl|ADSL]]|0.542|
|[[:human genes:h:hars|HARS]]|0.535|
|[[:human genes:r:rpe|RPE]]|0.532|
|[[:human genes:e:eny2|ENY2]]|0.523|
|[[:human genes:s:srp14|SRP14]]|0.521|
|[[:human genes:d:ddx20|DDX20]]|0.509|
|[[:human genes:u:uap1|UAP1]]|0.509|
|[[:human genes:d:dohh|DOHH]]|0.507|
|[[:human genes:r:rtcb|RTCB]]|0.502|
|[[:human genes:t:tbca|TBCA]]|0.5|
|[[:human genes:d:dhps|DHPS]]|0.498|
|[[:human genes:u:uhrf1|UHRF1]]|0.498|
|[[:human genes:h:hspd1|HSPD1]]|0.495|
|[[:human genes:a:alg2|ALG2]]|0.493|
|[[:human genes:g:gfpt1|GFPT1]]|0.492|
|[[:human genes:v:vezt|VEZT]]|0.483|
|[[:human genes:o:oraov1|ORAOV1]]|0.482|
|[[:human genes:t:ten1|TEN1]]|0.481|
|[[:human genes:g:gtf3c4|GTF3C4]]|0.481|
|[[:human genes:n:nae1|NAE1]]|0.48|
|[[:human genes:p:ppcs|PPCS]]|0.478|
|[[:human genes:a:atxn10|ATXN10]]|0.478|
|[[:human genes:a:alg5|ALG5]]|0.476|
|[[:human genes:g:gemin5|GEMIN5]]|0.475|
|[[:human genes:g:gtf2a2|GTF2A2]]|0.47|
|[[:human genes:a:alg13|ALG13]]|0.469|
|[[:human genes:t:txnl4b|TXNL4B]]|0.464|
|[[:human genes:t:timm22|TIMM22]]|0.462|
|[[:human genes:e:eif4e|EIF4E]]|0.459|
|[[:human genes:m:med16|MED16]]|0.459|
|[[:human genes:g:gtf3c2|GTF3C2]]|0.457|
|[[:human genes:h:haus8|HAUS8]]|0.457|
|[[:human genes:t:trnt1|TRNT1]]|0.454|
|[[:human genes:r:rad1|RAD1]]|0.453|
|[[:human genes:b:bap1|BAP1]]|0.452|
|[[:human genes:u:uxt|UXT]]|0.449|
|[[:human genes:y:yars|YARS]]|0.448|
|[[:human genes:d:dpf2|DPF2]]|0.448|
|[[:human genes:t:tsen54|TSEN54]]|0.447|
|[[:human genes:r:romo1|ROMO1]]|0.446|
|[[:human genes:e:exoc3|EXOC3]]|0.446|
|[[:human genes:c:cct7|CCT7]]|0.444|
|[[:human genes:f:fen1|FEN1]]|0.442|
|[[:human genes:t:taz|TAZ]]|0.442|
|[[:human genes:p:ppp2r3c|PPP2R3C]]|0.442|
|[[:human genes:g:gemin6|GEMIN6]]|0.44|
|[[:human genes:t:trmt10a|TRMT10A]]|0.44|
|[[:human genes:d:dad1|DAD1]]|0.439|
|[[:human genes:m:mtor|MTOR]]|0.438|
|[[:human genes:e:eprs|EPRS]]|0.438|
|[[:human genes:l:lsm10|LSM10]]|0.436|
|[[:human genes:r:rpia|RPIA]]|0.435|
|[[:human genes:r:rabggtb|RABGGTB]]|0.435|
|[[:human genes:p:ppp4c|PPP4C]]|0.435|
|[[:human genes:s:slc25a26|SLC25A26]]|0.435|
|[[:human genes:z:zrsr2|ZRSR2]]|0.432|
|[[:human genes:v:vrk1|VRK1]]|0.432|
|[[:human genes:u:urm1|URM1]]|0.431|
|[[:human genes:g:gemin8|GEMIN8]]|0.431|
|[[:human genes:d:dusp12|DUSP12]]|0.429|
|[[:human genes:g:gtf3c3|GTF3C3]]|0.429|
|[[:human genes:k:kdm8|KDM8]]|0.429|
|[[:human genes:f:faf2|FAF2]]|0.428|
|[[:human genes:s:sec61g|SEC61G]]|0.428|
|[[:human genes:n:naf1|NAF1]]|0.427|
|[[:human genes:c:ctc1|CTC1]]|0.427|
|[[:human genes:a:aasdhppt|AASDHPPT]]|0.426|
|[[:human genes:c:ccdc101|CCDC101]]|0.425|
|[[:human genes:t:tprkb|TPRKB]]|0.423|
|[[:human genes:t:timm13|TIMM13]]|0.419|
|[[:human genes:t:taf1a|TAF1A]]|0.419|
|[[:human genes:w:wdr82|WDR82]]|0.419|
|[[:human genes:p:pggt1b|PGGT1B]]|0.418|
|[[:human genes:h:hccs|HCCS]]|0.418|
|[[:human genes:u:ube2g2|UBE2G2]]|0.418|
|[[:human genes:g:ggps1|GGPS1]]|0.417|
|[[:human genes:t:ttc4|TTC4]]|0.417|
|[[:human genes:a:alg14|ALG14]]|0.416|
|[[:human genes:e:eno1|ENO1]]|0.416|
|[[:human genes:e:elp3|ELP3]]|0.415|
|[[:human genes:c:cbfb|CBFB]]|0.415|
|[[:human genes:t:tmem41b|TMEM41B]]|0.415|
|[[:human genes:p:plaa|PLAA]]|0.414|
|[[:human genes:f:fnta|FNTA]]|0.414|
|[[:human genes:g:gemin7|GEMIN7]]|0.414|
|[[:human genes:p:pam16|PAM16]]|0.414|
|[[:human genes:e:exoc4|EXOC4]]|0.412|
|[[:human genes:r:rft1|RFT1]]|0.412|
|[[:human genes:p:pdpk1|PDPK1]]|0.411|
|[[:human genes:g:gtf3c6|GTF3C6]]|0.41|
|[[:human genes:c:crls1|CRLS1]]|0.409|
|[[:human genes:n:nars|NARS]]|0.409|
|[[:human genes:c:chchd4|CHCHD4]]|0.409|
|[[:human genes:s:slc25a19|SLC25A19]]|0.409|
|[[:human genes:o:osgep|OSGEP]]|0.408|
|[[:human genes:a:alg6|ALG6]]|0.408|
|[[:human genes:z:znhit1|ZNHIT1]]|0.407|
|[[:human genes:t:telo2|TELO2]]|0.407|
|[[:human genes:r:rpn1|RPN1]]|0.407|
|[[:human genes:c:cdipt|CDIPT]]|0.404|
|[[:human genes:e:ercc2|ERCC2]]|0.403|
|[[:human genes:m:mars|MARS]]|0.403|
|[[:human genes:s:sgol1|SGOL1]]|0.403|
|[[:human genes:d:dolk|DOLK]]|0.401|
|[[:human genes:l:lsm11|LSM11]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 112/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|4/28|
|blood|6/28|
|bone|2/26|
|breast|2/33|
|central nervous system|11/56|
|cervix|1/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|1/16|
|kidney|1/21|
|liver|5/20|
|lung|15/75|
|lymphocyte|4/16|
|ovary|3/26|
|pancreas|1/24|
|peripheral nervous system|8/16|
|plasma cell|5/15|
|prostate|0/1|
|skin|4/24|
|soft tissue|1/9|
|thyroid|0/2|
|upper aerodigestive|2/22|
|urinary tract|6/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 639
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.46 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UTP23 Expression in NALM6 Cells: 5.46'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>