======= UTP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: UTP3
  * **<color #00a2e8>Official Name</color>**: UTP3 small subunit processome component
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57050|57050]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q9NQZ2|Q9NQZ2]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=UTP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20UTP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/611614|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  Essential for gene silencing: has a role in the structure of silenced chromatin. Plays a role in the developing brain (By similarity). {ECO:0000250|UniProtKB:Q12136, ECO:0000250|UniProtKB:Q9JI13}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Sas10 Utp3 C|
|Sas10 Utp3|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)|
|small-subunit processome|
|maturation of SSU-rRNA|
|ribosomal small subunit biogenesis|
|rRNA processing|
|rRNA metabolic process|
|ribosome biogenesis|
|ncRNA processing|
|ribonucleoprotein complex biogenesis|
|ncRNA metabolic process|
|chromatin organization|
|brain development|
|head development|
|nucleolus|
|RNA processing|
|central nervous system development|
|chromosome organization|
|RNA binding|
|RNA metabolic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp4|Actinomycin-D 0.01μM R00 exp4]]|-1.88|
|[[:results:exp215|Colchicine 0.009μM R05 exp215]]|1.73|
|[[:results:exp484|GSK-J5 1.5μM R08 exp484]]|1.77|
|[[:results:exp528|TGF-beta1 44ng/ml R08 exp528]]|1.83|
|[[:results:exp10|CCCP 0.1μM R00 exp10]]|1.88|
|[[:results:exp533|TNF-alpha 44ng/ml R08 exp533]]|1.93|
|[[:results:exp508|NN-Dimethylsphingosine 2.5μM R08 exp508]]|2.14|
|[[:results:exp519|RS-1 10μM R08 exp519]]|2.35|
|[[:results:exp209|Deguelin 0.15μM R05 exp209]]|2.52|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:t:tceb3c|TCEB3C]]|0.551|
|[[:human genes:g:golga6l1|GOLGA6L1]]|0.55|
|[[:human genes:t:tceb3cl|TCEB3CL]]|0.546|
|[[:human genes:c:ccna2|CCNA2]]|0.546|
|[[:human genes:t:tbc1d3f|TBC1D3F]]|0.542|
|[[:human genes:c:copg1|COPG1]]|0.539|
|[[:human genes:c:cox7a2l|COX7A2L]]|0.528|
|[[:human genes:c:col2a1|COL2A1]]|0.524|
|[[:human genes:t:tceb3cl2|TCEB3CL2]]|0.515|
|[[:human genes:t:tbc1d3h|TBC1D3H]]|0.514|
|[[:human genes:s:slc4a1|SLC4A1]]|0.508|
|[[:human genes:v:vps28|VPS28]]|0.506|
|[[:human genes:n:nsf|NSF]]|0.504|
|[[:human genes:p:psmb4|PSMB4]]|0.503|
|[[:human genes:a:aamp|AAMP]]|0.501|
|[[:human genes:t:tbc1d3|TBC1D3]]|0.501|
|[[:human genes:i:ik|IK]]|0.497|
|[[:human genes:k:krt78|KRT78]]|0.497|
|[[:human genes:r:rps2|RPS2]]|0.494|
|[[:human genes:d:disp2|DISP2]]|0.492|
|[[:human genes:p:psmb2|PSMB2]]|0.492|
|[[:human genes:r:rrp7a|RRP7A]]|0.49|
|[[:human genes:n:npipb5|NPIPB5]]|0.49|
|[[:human genes:c:chd4|CHD4]]|0.489|
|[[:human genes:d:dtl|DTL]]|0.488|
|[[:human genes:t:tsg101|TSG101]]|0.488|
|[[:human genes:t:tbc1d3g|TBC1D3G]]|0.486|
|[[:human genes:r:ranbp2|RANBP2]]|0.485|
|[[:human genes:a:aqr|AQR]]|0.481|
|[[:human genes:a:acsf2|ACSF2]]|0.479|
|[[:human genes:p:pno1|PNO1]]|0.476|
|[[:human genes:p:pop7|POP7]]|0.474|
|[[:human genes:f:fam160a1|FAM160A1]]|0.473|
|[[:human genes:p:psma6|PSMA6]]|0.473|
|[[:human genes:a:atp6v1c1|ATP6V1C1]]|0.472|
|[[:human genes:n:napa|NAPA]]|0.47|
|[[:human genes:d:dock6|DOCK6]]|0.47|
|[[:human genes:p:polr1a|POLR1A]]|0.47|
|[[:human genes:a:ankle1|ANKLE1]]|0.469|
|[[:human genes:c:cep192|CEP192]]|0.469|
|[[:human genes:d:ddt|DDT]]|0.469|
|[[:human genes:e:eftud2|EFTUD2]]|0.468|
|[[:human genes:t:tbc1d3e|TBC1D3E]]|0.467|
|[[:human genes:t:tbc1d3l|TBC1D3L]]|0.467|
|[[:human genes:t:tbc1d3k|TBC1D3K]]|0.466|
|[[:human genes:t:tbc1d3i|TBC1D3I]]|0.466|
|[[:human genes:t:twistnb|TWISTNB]]|0.465|
|[[:human genes:c:copz1|COPZ1]]|0.463|
|[[:human genes:a:atp6v0b|ATP6V0B]]|0.46|
|[[:human genes:c:c14orf93|C14orf93]]|0.459|
|[[:human genes:c:cbwd3|CBWD3]]|0.459|
|[[:human genes:k:kctd17|KCTD17]]|0.459|
|[[:human genes:m:mt1e|MT1E]]|0.459|
|[[:human genes:e:ebna1bp2|EBNA1BP2]]|0.456|
|[[:human genes:p:plekha4|PLEKHA4]]|0.455|
|[[:human genes:c:copa|COPA]]|0.455|
|[[:human genes:t:tyms|TYMS]]|0.454|
|[[:human genes:s:slc6a17|SLC6A17]]|0.453|
|[[:human genes:c:cactin|CACTIN]]|0.453|
|[[:human genes:o:or10g3|OR10G3]]|0.453|
|[[:human genes:b:brd2|BRD2]]|0.453|
|[[:human genes:t:tfip11|TFIP11]]|0.453|
|[[:human genes:o:orc6|ORC6]]|0.452|
|[[:human genes:r:rrp9|RRP9]]|0.452|
|[[:human genes:c:cbwd5|CBWD5]]|0.451|
|[[:human genes:e:exosc9|EXOSC9]]|0.451|
|[[:human genes:e:exosc6|EXOSC6]]|0.45|
|[[:human genes:d:ddtl|DDTL]]|0.45|
|[[:human genes:a:atp1a3|ATP1A3]]|0.449|
|[[:human genes:c:cbwd6|CBWD6]]|0.448|
|[[:human genes:a:aatf|AATF]]|0.448|
|[[:human genes:s:supt5h|SUPT5H]]|0.448|
|[[:human genes:p:psmd2|PSMD2]]|0.447|
|[[:human genes:t:tp53tg3b|TP53TG3B]]|0.446|
|[[:human genes:t:tp53tg3|TP53TG3]]|0.445|
|[[:human genes:t:tp53tg3c|TP53TG3C]]|0.445|
|[[:human genes:e:eif3g|EIF3G]]|0.445|
|[[:human genes:s:snrpa1|SNRPA1]]|0.445|
|[[:human genes:v:vasn|VASN]]|0.444|
|[[:human genes:r:rpl35|RPL35]]|0.444|
|[[:human genes:h:hist2h3a|HIST2H3A]]|0.443|
|[[:human genes:x:xylt2|XYLT2]]|0.443|
|[[:human genes:h:hist2h3c|HIST2H3C]]|0.442|
|[[:human genes:n:nfatc4|NFATC4]]|0.441|
|[[:human genes:s:syt9|SYT9]]|0.441|
|[[:human genes:d:dhx38|DHX38]]|0.44|
|[[:human genes:u:usp35|USP35]]|0.438|
|[[:human genes:n:nol10|NOL10]]|0.438|
|[[:human genes:r:rpl6|RPL6]]|0.437|
|[[:human genes:z:znf830|ZNF830]]|0.436|
|[[:human genes:c:ctage4|CTAGE4]]|0.435|
|[[:human genes:p:pla2g4f|PLA2G4F]]|0.435|
|[[:human genes:z:znf655|ZNF655]]|0.434|
|[[:human genes:g:golga6l3|GOLGA6L3]]|0.433|
|[[:human genes:p:pan3|PAN3]]|0.433|
|[[:human genes:s:snip1|SNIP1]]|0.433|
|[[:human genes:u:upf1|UPF1]]|0.433|
|[[:human genes:n:nipbl|NIPBL]]|0.433|
|[[:human genes:i:ints5|INTS5]]|0.432|
|[[:human genes:c:cdt1|CDT1]]|0.432|
|[[:human genes:r:rbbp5|RBBP5]]|0.431|
|[[:human genes:a:akt1s1|AKT1S1]]|0.431|
|[[:human genes:t:tp53tg3d|TP53TG3D]]|0.431|
|[[:human genes:c:chaf1a|CHAF1A]]|0.43|
|[[:human genes:c:c2orf27b|C2orf27B]]|0.43|
|[[:human genes:p:psmd11|PSMD11]]|0.43|
|[[:human genes:n:narfl|NARFL]]|0.43|
|[[:human genes:g:gar1|GAR1]]|0.429|
|[[:human genes:s:sh3bp1|SH3BP1]]|0.428|
|[[:human genes:c:chmp4b|CHMP4B]]|0.428|
|[[:human genes:c:ccdc116|CCDC116]]|0.428|
|[[:human genes:p:polr2f|POLR2F]]|0.428|
|[[:human genes:r:rps19bp1|RPS19BP1]]|0.426|
|[[:human genes:n:nop16|NOP16]]|0.426|
|[[:human genes:p:psmc2|PSMC2]]|0.426|
|[[:human genes:h:hivep3|HIVEP3]]|0.425|
|[[:human genes:r:rpl8|RPL8]]|0.425|
|[[:human genes:t:ticrr|TICRR]]|0.424|
|[[:human genes:c:cdh24|CDH24]]|0.423|
|[[:human genes:r:rrp15|RRP15]]|0.423|
|[[:human genes:p:prpf3|PRPF3]]|0.423|
|[[:human genes:c:cln6|CLN6]]|0.423|
|[[:human genes:c:cdca5|CDCA5]]|0.422|
|[[:human genes:u:utp20|UTP20]]|0.422|
|[[:human genes:e:exosc5|EXOSC5]]|0.421|
|[[:human genes:v:vps52|VPS52]]|0.421|
|[[:human genes:f:fam25b|FAM25B]]|0.421|
|[[:human genes:t:tbc1d3c|TBC1D3C]]|0.42|
|[[:human genes:p:polr2d|POLR2D]]|0.42|
|[[:human genes:t:timeless|TIMELESS]]|0.419|
|[[:human genes:r:rps12|RPS12]]|0.419|
|[[:human genes:r:rpp40|RPP40]]|0.419|
|[[:human genes:g:gnl2|GNL2]]|0.418|
|[[:human genes:p:polr2j3|POLR2J3]]|0.418|
|[[:human genes:a:atp6ap1|ATP6AP1]]|0.418|
|[[:human genes:g:gid4|GID4]]|0.418|
|[[:human genes:n:ncl|NCL]]|0.417|
|[[:human genes:r:rfc1|RFC1]]|0.417|
|[[:human genes:m:med14|MED14]]|0.417|
|[[:human genes:o:orc1|ORC1]]|0.416|
|[[:human genes:a:art5|ART5]]|0.415|
|[[:human genes:d:ddx56|DDX56]]|0.415|
|[[:human genes:o:osbp|OSBP]]|0.415|
|[[:human genes:i:igfn1|IGFN1]]|0.414|
|[[:human genes:p:psmc1|PSMC1]]|0.414|
|[[:human genes:s:smtn|SMTN]]|0.414|
|[[:human genes:c:clcn6|CLCN6]]|0.414|
|[[:human genes:l:lrr1|LRR1]]|0.413|
|[[:human genes:r:rps7|RPS7]]|0.413|
|[[:human genes:e:exosc3|EXOSC3]]|0.413|
|[[:human genes:p:pole|POLE]]|0.413|
|[[:human genes:n:nelfa|NELFA]]|0.412|
|[[:human genes:s:sap30bp|SAP30BP]]|0.412|
|[[:human genes:p:pola1|POLA1]]|0.412|
|[[:human genes:p:psma7|PSMA7]]|0.412|
|[[:human genes:t:tpx2|TPX2]]|0.412|
|[[:human genes:d:dimt1|DIMT1]]|0.411|
|[[:human genes:n:nol7|NOL7]]|0.411|
|[[:human genes:p:pdcd7|PDCD7]]|0.411|
|[[:human genes:m:mfsd12|MFSD12]]|0.41|
|[[:human genes:p:polr2i|POLR2I]]|0.41|
|[[:human genes:a:arcn1|ARCN1]]|0.41|
|[[:human genes:a:atp6v0c|ATP6V0C]]|0.41|
|[[:human genes:v:vps54|VPS54]]|0.409|
|[[:human genes:g:gga3|GGA3]]|0.409|
|[[:human genes:r:rps5|RPS5]]|0.409|
|[[:human genes:e:exd1|EXD1]]|0.409|
|[[:human genes:f:fbxw9|FBXW9]]|0.407|
|[[:human genes:r:rad51|RAD51]]|0.407|
|[[:human genes:m:mms22l|MMS22L]]|0.407|
|[[:human genes:m:mdn1|MDN1]]|0.407|
|[[:human genes:a:akirin2|AKIRIN2]]|0.407|
|[[:human genes:t:tuba8|TUBA8]]|0.407|
|[[:human genes:c:cdc45|CDC45]]|0.406|
|[[:human genes:s:supt6h|SUPT6H]]|0.406|
|[[:human genes:s:smg1|SMG1]]|0.406|
|[[:human genes:r:rpl30|RPL30]]|0.406|
|[[:human genes:t:tinf2|TINF2]]|0.406|
|[[:human genes:c:copb1|COPB1]]|0.406|
|[[:human genes:n:nupl1|NUPL1]]|0.405|
|[[:human genes:m:myb|MYB]]|0.405|
|[[:human genes:g:golga6b|GOLGA6B]]|0.405|
|[[:human genes:p:psmb1|PSMB1]]|0.404|
|[[:human genes:c:c1qtnf9b|C1QTNF9B]]|0.404|
|[[:human genes:e:egr2|EGR2]]|0.404|
|[[:human genes:r:rfpl3|RFPL3]]|0.403|
|[[:human genes:a:atp6v1a|ATP6V1A]]|0.402|
|[[:human genes:z:znf541|ZNF541]]|0.401|
|[[:human genes:r:rps10|RPS10]]|0.401|
|[[:human genes:p:psmd8|PSMD8]]|0.401|
|[[:human genes:r:rpl9|RPL9]]|0.4|
|[[:human genes:g:gosr2|GOSR2]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 458/726
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|1/1|
|909776.0|1/1|
|bile duct|17/28|
|blood|19/28|
|bone|16/25|
|breast|11/33|
|central nervous system|34/56|
|cervix|4/4|
|colorectal|12/17|
|esophagus|9/13|
|fibroblast|0/1|
|gastric|8/15|
|kidney|10/21|
|liver|11/20|
|lung|60/75|
|lymphocyte|10/14|
|ovary|17/26|
|pancreas|20/24|
|peripheral nervous system|11/16|
|plasma cell|8/15|
|prostate|0/1|
|skin|12/24|
|soft tissue|4/7|
|thyroid|2/2|
|upper aerodigestive|12/22|
|urinary tract|25/29|
|uterus|3/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 832
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 6.08 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='UTP3 Expression in NALM6 Cells: 6.08'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>