======= VAMP3 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAMP3
  * **<color #00a2e8>Official Name</color>**: vesicle associated membrane protein 3
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=9341|9341]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q15836|Q15836]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAMP3&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAMP3|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/603657|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**: N/A
  * **<color #00a2e8>UniProt Summary</color>**:  SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network. {ECO:0000269|PubMed:18195106}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Synaptobrevin|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|mucus secretion|
|regulation of histamine secretion by mast cell|
|SNARE complex assembly|
|positive regulation of immunoglobulin secretion|
|positive regulation of receptor recycling|
|regulation of immunoglobulin secretion|
|secretion by tissue|
|regulation of receptor recycling|
|syntaxin-1 binding|
|regulation of mast cell degranulation|
|integral component of synaptic vesicle membrane|
|Golgi to plasma membrane protein transport|
|regulation of mast cell activation involved in immune response|
|vesicle docking involved in exocytosis|
|calcium-ion regulated exocytosis|
|positive regulation of immunoglobulin production|
|regulation of mast cell activation|
|SNARE complex|
|regulation of leukocyte degranulation|
|substrate adhesion-dependent cell spreading|
|establishment of protein localization to plasma membrane|
|clathrin-coated vesicle membrane|
|clathrin-coated vesicle|
|regulation of myeloid leukocyte mediated immunity|
|Golgi to plasma membrane transport|
|vesicle docking|
|regulation of immunoglobulin production|
|exocytic process|
|carbohydrate derivative transport|
|vesicle fusion|
|phagocytic vesicle membrane|
|body fluid secretion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent|
|organelle membrane fusion|
|antigen processing and presentation of exogenous peptide antigen via MHC class I|
|recycling endosome membrane|
|secretory granule|
|transport vesicle|
|vesicle-mediated transport to the plasma membrane|
|trans-Golgi network membrane|
|retrograde transport, endosome to Golgi|
|organelle fusion|
|positive regulation of production of molecular mediator of immune response|
|antigen processing and presentation of peptide antigen via MHC class I|
|post-Golgi vesicle-mediated transport|
|recycling endosome|
|membrane fusion|
|regulation of production of molecular mediator of immune response|
|regulation of neurotransmitter transport|
|cytosolic transport|
|cellular response to interferon-gamma|
|regulation of regulated secretory pathway|
|organelle localization by membrane tethering|
|antigen processing and presentation of exogenous peptide antigen|
|membrane docking|
|response to interferon-gamma|
|protein localization to plasma membrane|
|antigen processing and presentation of exogenous antigen|
|cell-substrate adhesion|
|antigen processing and presentation of peptide antigen|
|negative regulation of secretion by cell|
|regulation of leukocyte mediated immunity|
|antigen processing and presentation|
|positive regulation of immune effector process|
|regulation of exocytosis|
|endosomal transport|
|protein localization to cell periphery|
|negative regulation of secretion|
|establishment of protein localization to membrane|
|regulation of hormone secretion|
|positive regulation of protein secretion|
|positive regulation of peptide secretion|
|vesicle organization|
|apical plasma membrane|
|neuron projection|
|regulation of inflammatory response|
|regulation of intracellular transport|
|Golgi vesicle transport|
|positive regulation of secretion by cell|
|positive regulation of protein transport|
|positive regulation of secretion|
|positive regulation of establishment of protein localization|
|regulation of protein secretion|
|regulation of immune effector process|
|protein localization to membrane|
|negative regulation of transport|
|regulation of peptide secretion|
|regulation of body fluid levels|
|regulation of hormone levels|
|cell junction|
|regulation of vesicle-mediated transport|
|cell morphogenesis involved in differentiation|
|organelle localization|
|regulation of leukocyte activation|
|cell surface|
|regulation of cell activation|
|intracellular membrane-bounded organelle|
|perinuclear region of cytoplasm|
|regulation of ion transport|
|regulated exocytosis|
|regulation of protein transport|
|cell morphogenesis|
|regulation of peptide transport|
|regulation of establishment of protein localization|
|regulation of secretion by cell|
|regulation of defense response|
|innate immune response|
|exocytosis|
|regulation of secretion|
|cellular component morphogenesis|
|cellular protein-containing complex assembly|
|membrane organization|
|regulation of cellular localization|
|cell adhesion|
|biological adhesion|
|defense response to other organism|
|positive regulation of transport|
|secretion by cell|
|cellular response to cytokine stimulus|
|regulation of protein localization|
|export from cell|
|regulation of response to external stimulus|
|response to cytokine|
|secretion|
|positive regulation of immune system process|
|regulation of immune response|
|response to other organism|
|response to external biotic stimulus|
|response to biotic stimulus|
|defense response|
|regulation of response to stress|
|protein transport|
|intracellular transport|
|peptide transport|
|protein-containing complex assembly|
|amide transport|
|cellular protein localization|
|cellular macromolecule localization|
|establishment of protein localization|
|cell development|
|regulation of immune system process|
|positive regulation of signaling|
|establishment of localization in cell|
|nitrogen compound transport|
|protein-containing complex subunit organization|
|regulation of transport|
|immune response|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp334|All-trans-Retinoic-Acid 40μM R07 exp334]]|1.73|
|[[:results:exp141|Nifurtimox 1μM R03 exp141]]|2|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 6367
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 4.62 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAMP3 Expression in NALM6 Cells: 4.62'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>