======= VARS2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VARS2
  * **<color #00a2e8>Official Name</color>**: valyl-tRNA synthetase 2, mitochondrial
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=57176|57176]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/Q5ST30|Q5ST30]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VARS2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VARS2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/612802|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes a mitochondrial aminoacyl-tRNA synthetase, which catalyzes the attachment of valine to tRNA(Val) for mitochondrial translation. Mutations in this gene cause combined oxidative phosphorylation deficiency-20, and are also associated with early-onset mitochondrial encephalopathies. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2014]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|tRNA-synt 1g|
|tRNA-synt 1|
|Anticodon 1|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|valyl-tRNA aminoacylation|
|valine-tRNA ligase activity|
|aminoacyl-tRNA editing activity|
|aminoacyl-tRNA metabolism involved in translational fidelity|
|regulation of translational fidelity|
|tRNA aminoacylation for protein translation|
|tRNA aminoacylation|
|amino acid activation|
|tRNA metabolic process|
|cellular amino acid metabolic process|
|translation|
|peptide biosynthetic process|
|ncRNA metabolic process|
|amide biosynthetic process|
|peptide metabolic process|
|cellular amide metabolic process|
|carboxylic acid metabolic process|
|oxoacid metabolic process|
|organic acid metabolic process|
|mitochondrion|
|organonitrogen compound biosynthetic process|
|ATP binding|
|cellular nitrogen compound biosynthetic process|
|RNA metabolic process|
|cellular macromolecule biosynthetic process|
|small molecule metabolic process|
|macromolecule biosynthetic process|
|gene expression|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='primary' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp159|Docetaxel 0.001 to 0.002μM on day4 R04 exp159]]|-1.88|
|[[:results:exp214|2-Deoxy-D-glucose 800μM R05 exp214]]|-1.77|
|[[:results:exp35|TRAIL 5ng/ml R00 exp35]]|-1.74|
|[[:results:exp503|Mitomycin-C 0.06μM R08 exp503]]|1.75|
|[[:results:exp441|GSK-J4 1.5μM R08 exp441]]|1.76|
|[[:results:exp515|PU-H71 1μM R08 exp515]]|1.76|
|[[:results:exp448|Ammonium tetrathiomolybdate 10μM R08 exp448]]|1.79|
|[[:results:exp217|Mdivi-1 15μM R05 exp217]]|1.79|
|[[:results:exp513|ONC212 0.15μM R08 exp513]]|1.8|
|[[:results:exp487|Hinokiflavone 12μM R08 exp487]]|1.85|
|[[:results:exp66|BI-D1870 3.15μM R02 exp66]]|1.9|
|[[:results:exp434|Vemurafenib 6.6μM R08 exp434]]|1.96|
|[[:results:exp440|Aphidicolin 0.4μM R08 exp440]]|1.99|
|[[:results:exp290|LLY-283 2.6μM R06 exp290]]|2.07|
|[[:results:exp350|Deferoxamine 11μM R07 exp350]]|2.14|
|[[:results:exp539|42°C R08 exp539]]|2.16|
|[[:results:exp447|Amiloride 100μM R08 exp447]]|2.18|
|[[:results:exp329|Hydroxyurea 100μM R07 exp329]]|2.2|
|[[:results:exp84|UM0125461 0.74μM R02 exp84]]|2.26|
|[[:results:exp507|Monensin 0.3μM R08 exp507]]|2.37|
|[[:results:exp346|CoCl2 18μM R07 exp346]]|2.39|
|[[:results:exp212|Phenformin 20μM R05 exp212]]|2.56|
|[[:results:exp529|Thimerosal 0.85μM R08 exp529]]|2.63|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
^Gene^Correlation^
|[[:human genes:y:yars2|YARS2]]|0.73|
|[[:human genes:h:hsd17b10|HSD17B10]]|0.705|
|[[:human genes:t:tars2|TARS2]]|0.705|
|[[:human genes:d:dap3|DAP3]]|0.694|
|[[:human genes:m:mrps14|MRPS14]]|0.69|
|[[:human genes:m:mrps21|MRPS21]]|0.688|
|[[:human genes:g:gfm1|GFM1]]|0.686|
|[[:human genes:m:mrpl53|MRPL53]]|0.684|
|[[:human genes:s:selrc1|SELRC1]]|0.682|
|[[:human genes:n:nars2|NARS2]]|0.677|
|[[:human genes:r:rpusd4|RPUSD4]]|0.675|
|[[:human genes:m:mrpl23|MRPL23]]|0.675|
|[[:human genes:m:mrps16|MRPS16]]|0.672|
|[[:human genes:s:sco2|SCO2]]|0.668|
|[[:human genes:m:mrps34|MRPS34]]|0.664|
|[[:human genes:m:mrp63|MRP63]]|0.663|
|[[:human genes:d:dars2|DARS2]]|0.661|
|[[:human genes:q:qrsl1|QRSL1]]|0.657|
|[[:human genes:m:mrps18a|MRPS18A]]|0.657|
|[[:human genes:p:pars2|PARS2]]|0.654|
|[[:human genes:m:mars2|MARS2]]|0.65|
|[[:human genes:m:mrpl21|MRPL21]]|0.648|
|[[:human genes:m:mrps6|MRPS6]]|0.647|
|[[:human genes:m:mrps26|MRPS26]]|0.647|
|[[:human genes:m:mrps5|MRPS5]]|0.639|
|[[:human genes:e:ears2|EARS2]]|0.639|
|[[:human genes:c:cox16|COX16]]|0.638|
|[[:human genes:f:fastkd5|FASTKD5]]|0.634|
|[[:human genes:l:lars2|LARS2]]|0.632|
|[[:human genes:m:mrpl47|MRPL47]]|0.628|
|[[:human genes:c:c10orf2|C10orf2]]|0.626|
|[[:human genes:s:sars2|SARS2]]|0.625|
|[[:human genes:c:coa3|COA3]]|0.623|
|[[:human genes:b:bcs1l|BCS1L]]|0.621|
|[[:human genes:f:ftsj2|FTSJ2]]|0.621|
|[[:human genes:a:aars2|AARS2]]|0.611|
|[[:human genes:k:kiaa0391|KIAA0391]]|0.61|
|[[:human genes:c:cox15|COX15]]|0.606|
|[[:human genes:m:mrps24|MRPS24]]|0.604|
|[[:human genes:m:mrpl3|MRPL3]]|0.603|
|[[:human genes:r:rars2|RARS2]]|0.603|
|[[:human genes:h:hars2|HARS2]]|0.601|
|[[:human genes:s:supv3l1|SUPV3L1]]|0.599|
|[[:human genes:r:rbfa|RBFA]]|0.597|
|[[:human genes:m:mrps2|MRPS2]]|0.597|
|[[:human genes:m:mrps12|MRPS12]]|0.596|
|[[:human genes:f:fars2|FARS2]]|0.594|
|[[:human genes:c:coa6|COA6]]|0.593|
|[[:human genes:p:pet112|PET112]]|0.592|
|[[:human genes:m:mrps9|MRPS9]]|0.59|
|[[:human genes:m:mrpl20|MRPL20]]|0.586|
|[[:human genes:m:mrps10|MRPS10]]|0.582|
|[[:human genes:m:mrpl12|MRPL12]]|0.581|
|[[:human genes:m:mrps25|MRPS25]]|0.58|
|[[:human genes:c:cox7b|COX7B]]|0.578|
|[[:human genes:t:tefm|TEFM]]|0.576|
|[[:human genes:t:tufm|TUFM]]|0.574|
|[[:human genes:p:pnpt1|PNPT1]]|0.574|
|[[:human genes:n:ndufb11|NDUFB11]]|0.572|
|[[:human genes:p:polg2|POLG2]]|0.572|
|[[:human genes:m:mrpl33|MRPL33]]|0.571|
|[[:human genes:t:tfam|TFAM]]|0.571|
|[[:human genes:n:ndufa3|NDUFA3]]|0.57|
|[[:human genes:m:mrps23|MRPS23]]|0.568|
|[[:human genes:g:gatc|GATC]]|0.567|
|[[:human genes:m:mrpl45|MRPL45]]|0.564|
|[[:human genes:t:tomm20|TOMM20]]|0.562|
|[[:human genes:t:trub2|TRUB2]]|0.56|
|[[:human genes:n:ndufaf7|NDUFAF7]]|0.56|
|[[:human genes:s:slc25a26|SLC25A26]]|0.557|
|[[:human genes:r:rnaseh1|RNASEH1]]|0.557|
|[[:human genes:g:gfm2|GFM2]]|0.557|
|[[:human genes:c:c12orf65|C12orf65]]|0.555|
|[[:human genes:m:mrpl55|MRPL55]]|0.55|
|[[:human genes:c:coq2|COQ2]]|0.549|
|[[:human genes:w:wbscr16|WBSCR16]]|0.548|
|[[:human genes:u:uqcrc2|UQCRC2]]|0.547|
|[[:human genes:m:mtg2|MTG2]]|0.546|
|[[:human genes:m:mrpl18|MRPL18]]|0.541|
|[[:human genes:m:mtrf1l|MTRF1L]]|0.541|
|[[:human genes:g:gtpbp10|GTPBP10]]|0.54|
|[[:human genes:m:mrpl15|MRPL15]]|0.539|
|[[:human genes:c:cox11|COX11]]|0.538|
|[[:human genes:m:mrps7|MRPS7]]|0.527|
|[[:human genes:m:mtpap|MTPAP]]|0.526|
|[[:human genes:a:aifm1|AIFM1]]|0.518|
|[[:human genes:m:mrpl52|MRPL52]]|0.515|
|[[:human genes:m:mrps27|MRPS27]]|0.514|
|[[:human genes:m:mrps11|MRPS11]]|0.512|
|[[:human genes:m:mrps35|MRPS35]]|0.512|
|[[:human genes:m:mrps33|MRPS33]]|0.511|
|[[:human genes:m:mettl17|METTL17]]|0.507|
|[[:human genes:m:mrpl44|MRPL44]]|0.505|
|[[:human genes:m:mrps17|MRPS17]]|0.505|
|[[:human genes:c:cars2|CARS2]]|0.505|
|[[:human genes:p:pet117|PET117]]|0.504|
|[[:human genes:m:mrpl39|MRPL39]]|0.504|
|[[:human genes:c:cox6c|COX6C]]|0.503|
|[[:human genes:t:tmem242|TMEM242]]|0.503|
|[[:human genes:m:mrpl4|MRPL4]]|0.502|
|[[:human genes:p:pgm3|PGM3]]|0.501|
|[[:human genes:p:pdss1|PDSS1]]|0.501|
|[[:human genes:r:rpusd3|RPUSD3]]|0.501|
|[[:human genes:u:uqcr10|UQCR10]]|0.499|
|[[:human genes:m:mrpl43|MRPL43]]|0.496|
|[[:human genes:r:rnmtl1|RNMTL1]]|0.496|
|[[:human genes:m:mrpl34|MRPL34]]|0.496|
|[[:human genes:n:ndufv1|NDUFV1]]|0.496|
|[[:human genes:m:mrpl13|MRPL13]]|0.495|
|[[:human genes:c:c17orf89|C17orf89]]|0.492|
|[[:human genes:c:coa5|COA5]]|0.491|
|[[:human genes:m:malsu1|MALSU1]]|0.491|
|[[:human genes:m:mrpl42|MRPL42]]|0.49|
|[[:human genes:p:polrmt|POLRMT]]|0.489|
|[[:human genes:m:mterfd2|MTERFD2]]|0.489|
|[[:human genes:m:mrpl36|MRPL36]]|0.489|
|[[:human genes:a:atp5d|ATP5D]]|0.488|
|[[:human genes:r:rtn4ip1|RTN4IP1]]|0.488|
|[[:human genes:w:wars2|WARS2]]|0.487|
|[[:human genes:n:ndufa1|NDUFA1]]|0.485|
|[[:human genes:a:atp5a1|ATP5A1]]|0.484|
|[[:human genes:o:opa1|OPA1]]|0.484|
|[[:human genes:m:mtif3|MTIF3]]|0.484|
|[[:human genes:c:cox17|COX17]]|0.482|
|[[:human genes:c:coq3|COQ3]]|0.481|
|[[:human genes:l:lrpprc|LRPPRC]]|0.48|
|[[:human genes:m:mrps22|MRPS22]]|0.479|
|[[:human genes:a:atp5c1|ATP5C1]]|0.478|
|[[:human genes:t:timm8b|TIMM8B]]|0.476|
|[[:human genes:d:dnlz|DNLZ]]|0.476|
|[[:human genes:e:elac2|ELAC2]]|0.474|
|[[:human genes:n:ndufaf4|NDUFAF4]]|0.473|
|[[:human genes:n:ndufs7|NDUFS7]]|0.467|
|[[:human genes:e:eral1|ERAL1]]|0.467|
|[[:human genes:n:ndufc2|NDUFC2]]|0.467|
|[[:human genes:d:dhrsx|DHRSX]]|0.466|
|[[:human genes:d:dhx30|DHX30]]|0.464|
|[[:human genes:n:ndufa2|NDUFA2]]|0.464|
|[[:human genes:t:tfb1m|TFB1M]]|0.463|
|[[:human genes:m:mrpl28|MRPL28]]|0.463|
|[[:human genes:p:polg|POLG]]|0.463|
|[[:human genes:m:mtg1|MTG1]]|0.461|
|[[:human genes:e:ecsit|ECSIT]]|0.46|
|[[:human genes:u:uqcc2|UQCC2]]|0.46|
|[[:human genes:n:ndufaf3|NDUFAF3]]|0.459|
|[[:human genes:t:tfb2m|TFB2M]]|0.459|
|[[:human genes:m:mrpl35|MRPL35]]|0.458|
|[[:human genes:m:mipep|MIPEP]]|0.457|
|[[:human genes:t:triap1|TRIAP1]]|0.456|
|[[:human genes:h:hccs|HCCS]]|0.455|
|[[:human genes:m:mrpl46|MRPL46]]|0.455|
|[[:human genes:n:ndufb5|NDUFB5]]|0.454|
|[[:human genes:g:gtpbp6|GTPBP6]]|0.452|
|[[:human genes:d:ddx28|DDX28]]|0.451|
|[[:human genes:n:ndufs2|NDUFS2]]|0.45|
|[[:human genes:n:ndufb3|NDUFB3]]|0.45|
|[[:human genes:p:ptcd3|PTCD3]]|0.45|
|[[:human genes:m:mrpl17|MRPL17]]|0.449|
|[[:human genes:n:ndufb6|NDUFB6]]|0.449|
|[[:human genes:h:higd2a|HIGD2A]]|0.448|
|[[:human genes:m:mrpl22|MRPL22]]|0.448|
|[[:human genes:t:trmt10c|TRMT10C]]|0.445|
|[[:human genes:c:cox6b1|COX6B1]]|0.443|
|[[:human genes:a:atp5b|ATP5B]]|0.443|
|[[:human genes:a:aldh18a1|ALDH18A1]]|0.443|
|[[:human genes:c:coq4|COQ4]]|0.441|
|[[:human genes:u:uqcrq|UQCRQ]]|0.441|
|[[:human genes:t:tmem126b|TMEM126B]]|0.441|
|[[:human genes:u:uqcrc1|UQCRC1]]|0.437|
|[[:human genes:t:tomm7|TOMM7]]|0.434|
|[[:human genes:m:mrpl11|MRPL11]]|0.434|
|[[:human genes:c:crls1|CRLS1]]|0.434|
|[[:human genes:c:chchd1|CHCHD1]]|0.433|
|[[:human genes:c:chchd4|CHCHD4]]|0.432|
|[[:human genes:c:cox5a|COX5A]]|0.432|
|[[:human genes:i:iba57|IBA57]]|0.431|
|[[:human genes:m:mterfd1|MTERFD1]]|0.429|
|[[:human genes:m:mrpl1|MRPL1]]|0.427|
|[[:human genes:m:mrpl38|MRPL38]]|0.427|
|[[:human genes:m:mrps28|MRPS28]]|0.425|
|[[:human genes:a:acad9|ACAD9]]|0.425|
|[[:human genes:n:ndufb1|NDUFB1]]|0.424|
|[[:human genes:t:trmt61a|TRMT61A]]|0.424|
|[[:human genes:c:cox10|COX10]]|0.423|
|[[:human genes:m:mrpl32|MRPL32]]|0.423|
|[[:human genes:m:mcat|MCAT]]|0.422|
|[[:human genes:c:coq7|COQ7]]|0.421|
|[[:human genes:l:lsm10|LSM10]]|0.421|
|[[:human genes:f:fh|FH]]|0.419|
|[[:human genes:c:coq6|COQ6]]|0.419|
|[[:human genes:s:slc25a3|SLC25A3]]|0.418|
|[[:human genes:m:mrpl54|MRPL54]]|0.417|
|[[:human genes:p:ppcs|PPCS]]|0.417|
|[[:human genes:n:ndufs5|NDUFS5]]|0.415|
|[[:human genes:p:prkrir|PRKRIR]]|0.414|
|[[:human genes:t:tamm41|TAMM41]]|0.413|
|[[:human genes:t:timmdc1|TIMMDC1]]|0.413|
|[[:human genes:m:mrpl2|MRPL2]]|0.413|
|[[:human genes:m:mrpl10|MRPL10]]|0.412|
|[[:human genes:t:tpk1|TPK1]]|0.412|
|[[:human genes:t:tomm6|TOMM6]]|0.412|
|[[:human genes:s:slc31a1|SLC31A1]]|0.409|
|[[:human genes:g:gtpbp8|GTPBP8]]|0.409|
|[[:human genes:m:mrpl49|MRPL49]]|0.409|
|[[:human genes:a:atp5sl|ATP5SL]]|0.409|
|[[:human genes:a:atp5j|ATP5J]]|0.409|
|[[:human genes:m:mrpl37|MRPL37]]|0.408|
|[[:human genes:t:taz|TAZ]]|0.406|
|[[:human genes:c:cox20|COX20]]|0.406|
|[[:human genes:c:cox7c|COX7C]]|0.406|
|[[:human genes:m:mtif2|MTIF2]]|0.406|
|[[:human genes:m:mrpl27|MRPL27]]|0.405|
|[[:human genes:a:atp5o|ATP5O]]|0.405|
|[[:human genes:t:tomm40|TOMM40]]|0.405|
|[[:human genes:p:pggt1b|PGGT1B]]|0.404|
|[[:human genes:n:ndufaf5|NDUFAF5]]|0.403|
|[[:human genes:g:grsf1|GRSF1]]|0.403|
|[[:human genes:n:ndufa8|NDUFA8]]|0.403|
|[[:human genes:h:hmgxb3|HMGXB3]]|0.402|
|[[:human genes:t:trmt10a|TRMT10A]]|0.402|
|[[:human genes:t:tomm22|TOMM22]]|0.401|
|[[:human genes:a:alg8|ALG8]]|0.4|
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 60/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|2/28|
|blood|1/28|
|bone|2/26|
|breast|4/33|
|central nervous system|4/56|
|cervix|1/4|
|colorectal|3/17|
|esophagus|1/13|
|fibroblast|0/1|
|gastric|3/16|
|kidney|3/21|
|liver|4/20|
|lung|7/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|1/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|5/22|
|urinary tract|2/29|
|uterus|1/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 479
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 5.71 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VARS2 Expression in NALM6 Cells: 5.71'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>