======= VAV2 =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VAV2
  * **<color #00a2e8>Official Name</color>**: vav guanine nucleotide exchange factor 2
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7410|7410]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P52735|P52735]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VAV2&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VAV2|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/600428|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  VAV2 is the second member of the VAV guanine nucleotide exchange factor family of oncogenes. Unlike VAV1, which is expressed exclusively in hematopoietic cells, VAV2 transcripts were found in most tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]. 
  * **<color #00a2e8>UniProt Summary</color>**: N/A

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|PH|
|SH3 1|
|CAMSAP CH|
|CH|
|SH3 2|
|SH2|
|C1 1|
|RhoGEF|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|positive regulation of phosphatidylinositol 3-kinase activity|
|epidermal growth factor receptor binding|
|lamellipodium assembly|
|positive regulation of lipid kinase activity|
|phosphotyrosine residue binding|
|lamellipodium organization|
|positive regulation of phospholipid metabolic process|
|regulation of phosphatidylinositol 3-kinase activity|
|regulation of lipid kinase activity|
|vascular endothelial growth factor receptor signaling pathway|
|Rho guanyl-nucleotide exchange factor activity|
|regulation of phospholipid metabolic process|
|ephrin receptor signaling pathway|
|guanyl-nucleotide exchange factor activity|
|immune response-regulating cell surface receptor signaling pathway involved in phagocytosis|
|Fc-gamma receptor signaling pathway involved in phagocytosis|
|Fc receptor mediated stimulatory signaling pathway|
|platelet activation|
|Fc-gamma receptor signaling pathway|
|positive regulation of lipid metabolic process|
|regulation of Rho protein signal transduction|
|Fc-epsilon receptor signaling pathway|
|regulation of cell size|
|Fc receptor signaling pathway|
|regulation of Ras protein signal transduction|
|blood coagulation|
|coagulation|
|hemostasis|
|angiogenesis|
|small GTPase mediated signal transduction|
|phagocytosis|
|regulation of small GTPase mediated signal transduction|
|regulation of cellular component size|
|regulation of lipid metabolic process|
|blood vessel morphogenesis|
|plasma membrane bounded cell projection assembly|
|immune response-activating cell surface receptor signaling pathway|
|cell projection assembly|
|wound healing|
|immune response-regulating cell surface receptor signaling pathway|
|regulation of GTPase activity|
|blood vessel development|
|regulation of body fluid levels|
|transmembrane receptor protein tyrosine kinase signaling pathway|
|vasculature development|
|regulation of anatomical structure size|
|cardiovascular system development|
|immune response-activating signal transduction|
|response to wounding|
|positive regulation of kinase activity|
|immune response-regulating signaling pathway|
|activation of immune response|
|positive regulation of apoptotic process|
|positive regulation of programmed cell death|
|tube morphogenesis|
|positive regulation of transferase activity|
|positive regulation of cell death|
|enzyme linked receptor protein signaling pathway|
|tube development|
|positive regulation of immune response|
|circulatory system development|
|regulation of kinase activity|
|anatomical structure formation involved in morphogenesis|
|cell migration|
|regulation of transferase activity|
|positive regulation of phosphorylation|
|cell activation|
|cell motility|
|localization of cell|
|immune effector process|
|plasma membrane bounded cell projection organization|
|positive regulation of phosphorus metabolic process|
|positive regulation of phosphate metabolic process|
|positive regulation of immune system process|
|regulation of immune response|
|cell projection organization|
|regulation of hydrolase activity|
|locomotion|
|G protein-coupled receptor signaling pathway|
|positive regulation of catalytic activity|
|regulation of apoptotic process|
|movement of cell or subcellular component|
|regulation of programmed cell death|
|regulation of phosphorylation|
|regulation of immune system process|
|regulation of cell death|
|intracellular signal transduction|
|positive regulation of molecular function|
|regulation of phosphate metabolic process|
|regulation of phosphorus metabolic process|
|regulation of intracellular signal transduction|
|vesicle-mediated transport|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp233|EPZ-5676 30μM R05 exp233]]|1.84|
|[[:results:exp500|LY2090314 0.003μM R08 exp500 no dilution day6]]|1.93|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 1/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|1/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 7660
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: -1.0 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VAV2 Expression in NALM6 Cells: -1.0'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>