======= VDR =======


== Gene Information ==
  * **<color #00a2e8>Official Symbol</color>**: VDR
  * **<color #00a2e8>Official Name</color>**: vitamin D receptor
  * **<color #00a2e8>Aliases and Previous Symbols</color>**: N/A
  * **<color #00a2e8>Entrez ID</color>**: [[https://www.ncbi.nlm.nih.gov/gene/?term=7421|7421]]
  * **<color #00a2e8>UniProt</color>**: [[https://www.uniprot.org/uniprot/P11473|P11473]]
  * **<color #00a2e8>Interactions</color>**: [[https://thebiogrid.org/search.php?search=VDR&organism=9606|BioGRID]]
  * **<color #00a2e8>PubMed articles</color>**: [[https://www.ncbi.nlm.nih.gov/pubmed/?term=gene%20VDR|Open PubMed]]
  * **<color #00a2e8>OMIM</color>**: [[https://omim.org/entry/601769|Open OMIM]]

== Function Summary ==
  * **<color #00a2e8>Entrez Summary</color>**:  This gene encodes the nuclear hormone receptor for vitamin D3. This receptor also functions as a receptor for the secondary bile acid lithocholic acid. The receptor belongs to the family of trans-acting transcriptional regulatory factors and shows sequence similarity to the steroid and thyroid hormone receptors. Downstream targets of this nuclear hormone receptor are principally involved in mineral metabolism though the receptor regulates a variety of other metabolic pathways, such as those involved in the immune response and cancer. Mutations in this gene are associated with type II vitamin D-resistant rickets. A single nucleotide polymorphism in the initiation codon results in an alternate translation start site three codons downstream. Alternative splicing results in multiple transcript variants encoding different proteins. [provided by RefSeq, Feb 2011]. 
  * **<color #00a2e8>UniProt Summary</color>**:  Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis. {ECO:0000269|PubMed:10678179, ECO:0000269|PubMed:15728261, ECO:0000269|PubMed:16252006, ECO:0000269|PubMed:16913708, ECO:0000269|PubMed:28698609}.

<button type='primary' size='sm' modal='Pfam_Domains'>Pfam Domains</button>
<button type='primary' size='sm' modal='GO_terms'>GO Terms</button>


<modal id='Pfam_Domains' size='lg' title='Pfam Domains'>
|Hormone recep|
|zf-C4|
</modal>

<modal id='GO_terms' size='lg' title='GO Terms'>
|calcitriol binding|
|lithocholic acid binding|
|lithocholic acid receptor activity|
|positive regulation of mammary gland involution|
|regulation of mammary gland involution|
|positive regulation of apoptotic process involved in mammary gland involution|
|vitamin D receptor signaling pathway|
|vitamin D response element binding|
|positive regulation of vitamin D 24-hydroxylase activity|
|bile acid signaling pathway|
|regulation of vitamin D 24-hydroxylase activity|
|positive regulation of apoptotic process involved in morphogenesis|
|positive regulation of apoptotic process involved in development|
|mammary gland branching involved in pregnancy|
|vitamin D binding|
|regulation of calcidiol 1-monooxygenase activity|
|regulation of vitamin D biosynthetic process|
|regulation of apoptotic process involved in morphogenesis|
|regulation of apoptotic process involved in development|
|regulation of vitamin metabolic process|
|negative regulation of keratinocyte proliferation|
|vitamin D metabolic process|
|cellular response to vitamin D|
|positive regulation of keratinocyte differentiation|
|retinoid X receptor binding|
|branching involved in mammary gland duct morphogenesis|
|decidualization|
|cellular response to vitamin|
|positive regulation of epidermal cell differentiation|
|regulation of hormone biosynthetic process|
|response to vitamin D|
|positive regulation of tissue remodeling|
|mammary gland duct morphogenesis|
|intestinal absorption|
|regulation of keratinocyte proliferation|
|maternal placenta development|
|fat-soluble vitamin metabolic process|
|regulation of hormone metabolic process|
|positive regulation of epidermis development|
|regulation of keratinocyte differentiation|
|mammary gland morphogenesis|
|lactation|
|nuclear receptor activity|
|steroid hormone receptor activity|
|positive regulation of oxidoreductase activity|
|regulation of monooxygenase activity|
|mammary gland epithelium development|
|positive regulation of epithelial cell differentiation|
|regulation of epidermal cell differentiation|
|maternal process involved in female pregnancy|
|nuclear receptor transcription coactivator activity|
|cellular response to nutrient|
|RNA polymerase II transcription factor complex|
|digestive system process|
|regulation of tissue remodeling|
|body fluid secretion|
|regulation of alcohol biosynthetic process|
|transcription regulatory region sequence-specific DNA binding|
|positive regulation of animal organ morphogenesis|
|regulation of epidermis development|
|response to vitamin|
|regulation of steroid biosynthetic process|
|regulation of oxidoreductase activity|
|gland morphogenesis|
|digestion|
|regulation of steroid metabolic process|
|steroid hormone mediated signaling pathway|
|negative regulation of epithelial cell proliferation|
|vitamin metabolic process|
|mammary gland development|
|branching morphogenesis of an epithelial tube|
|regulation of epithelial cell differentiation|
|placenta development|
|morphogenesis of a branching epithelium|
|intracellular receptor signaling pathway|
|morphogenesis of a branching structure|
|hormone-mediated signaling pathway|
|transcription initiation from RNA polymerase II promoter|
|female pregnancy|
|regulation of lipid biosynthetic process|
|cellular response to steroid hormone stimulus|
|signaling receptor activity|
|receptor complex|
|multi-multicellular organism process|
|response to nutrient|
|DNA-templated transcription, initiation|
|cellular response to nutrient levels|
|calcium ion transport|
|regulation of animal organ morphogenesis|
|steroid metabolic process|
|cellular response to extracellular stimulus|
|divalent metal ion transport|
|divalent inorganic cation transport|
|epithelial tube morphogenesis|
|RNA polymerase II regulatory region sequence-specific DNA binding|
|response to steroid hormone|
|transcription factor binding|
|regulation of epithelial cell proliferation|
|cellular response to external stimulus|
|regulation of lipid metabolic process|
|gland development|
|reproductive structure development|
|regulation of small molecule metabolic process|
|reproductive system development|
|morphogenesis of an epithelium|
|cellular calcium ion homeostasis|
|calcium ion homeostasis|
|organic hydroxy compound metabolic process|
|cellular divalent inorganic cation homeostasis|
|transcription by RNA polymerase II|
|divalent inorganic cation homeostasis|
|skeletal system development|
|regulation of body fluid levels|
|response to nutrient levels|
|cellular response to lipid|
|response to extracellular stimulus|
|regulation of hormone levels|
|cellular response to organic cyclic compound|
|cellular metal ion homeostasis|
|tissue morphogenesis|
|cellular response to hormone stimulus|
|metal ion homeostasis|
|cellular cation homeostasis|
|metal ion transport|
|transcription, DNA-templated|
|nucleic acid-templated transcription|
|positive regulation of apoptotic process|
|cellular ion homeostasis|
|positive regulation of programmed cell death|
|RNA biosynthetic process|
|tube morphogenesis|
|developmental process involved in reproduction|
|negative regulation of cell population proliferation|
|DNA-binding transcription factor activity|
|positive regulation of cell death|
|cation homeostasis|
|inorganic ion homeostasis|
|cell morphogenesis|
|cellular chemical homeostasis|
|ion homeostasis|
|cellular component morphogenesis|
|multicellular organismal reproductive process|
|cation transport|
|zinc ion binding|
|multicellular organism reproduction|
|tube development|
|response to lipid|
|negative regulation of transcription by RNA polymerase II|
|cellular homeostasis|
|response to hormone|
|response to organic cyclic compound|
|animal organ morphogenesis|
|positive regulation of cell differentiation|
|multi-organism reproductive process|
|cellular response to oxygen-containing compound|
|regulation of anatomical structure morphogenesis|
|nucleobase-containing compound biosynthetic process|
|chemical homeostasis|
|epithelium development|
|secretion|
|heterocycle biosynthetic process|
|aromatic compound biosynthetic process|
|negative regulation of transcription, DNA-templated|
|lipid metabolic process|
|positive regulation of transcription by RNA polymerase II|
|cellular response to endogenous stimulus|
|negative regulation of nucleic acid-templated transcription|
|negative regulation of RNA biosynthetic process|
|organic cyclic compound biosynthetic process|
|negative regulation of RNA metabolic process|
|positive regulation of developmental process|
|ion transport|
|negative regulation of cellular macromolecule biosynthetic process|
|reproductive process|
|reproduction|
|positive regulation of catalytic activity|
|negative regulation of nucleobase-containing compound metabolic process|
|DNA binding|
|negative regulation of macromolecule biosynthetic process|
|response to endogenous stimulus|
|negative regulation of cellular biosynthetic process|
|positive regulation of transcription, DNA-templated|
|regulation of apoptotic process|
|negative regulation of biosynthetic process|
|response to oxygen-containing compound|
|DNA-binding transcription factor activity, RNA polymerase II-specific|
|regulation of programmed cell death|
|regulation of cell population proliferation|
|cellular nitrogen compound biosynthetic process|
|positive regulation of nucleic acid-templated transcription|
|positive regulation of RNA biosynthetic process|
|homeostatic process|
|RNA metabolic process|
|regulation of cell death|
|cellular macromolecule biosynthetic process|
|negative regulation of gene expression|
|positive regulation of RNA metabolic process|
|positive regulation of multicellular organismal process|
|small molecule metabolic process|
|tissue development|
|macromolecule biosynthetic process|
|positive regulation of molecular function|
|regulation of cell differentiation|
|positive regulation of nucleobase-containing compound metabolic process|
|positive regulation of macromolecule biosynthetic process|
|system process|
|positive regulation of cellular biosynthetic process|
|positive regulation of gene expression|
|gene expression|
|positive regulation of biosynthetic process|
</modal>
\\

 === CRISPR Data ===
<button type='primary' size='small' modal='Compound_Hit'>Compound Hit</button>
<button type='default' size='small' modal='Most_Correlated_Genes'>Most Correlated Genes in Chemogenomics</button>
<button type='primary' size='small' modal='Essential_Avana'>Tissues where Essential in the Avana Dataset (DepMap 20Q1)</button>

<modal id='Compound_Hit' size='lg' title='Compound Hit'>
^Screen^Score^
|[[:results:exp6|Bortezomib 0.005μM R00 exp6]]|-1.96|
|[[:results:exp179|Combretastatin A4 0.002 to 0.003μM day4 R04 exp179]]|1.85|
|[[:results:exp99|NFN1 0.4μM R03 exp99]]|1.91|
</modal>

<modal id='Most_Correlated_Genes' size='lg' title='Most Correlated Genes in Chemogenomics'>
No correlation found to any other genes in chemogenomics.
</modal>

<modal id='Essential_Avana' size='lg' title='Tissues where Essential in the Avana Dataset (DepMap 20Q1)'>
Global Fraction of Cell Lines Where Essential: 0/739
^Tissue^Fraction Of Cell Lines Where Essential^
|1290807.0|0/1|
|909776.0|0/1|
|bile duct|0/28|
|blood|0/28|
|bone|0/26|
|breast|0/33|
|central nervous system|0/56|
|cervix|0/4|
|colorectal|0/17|
|esophagus|0/13|
|fibroblast|0/1|
|gastric|0/16|
|kidney|0/21|
|liver|0/20|
|lung|0/75|
|lymphocyte|0/16|
|ovary|0/26|
|pancreas|0/24|
|peripheral nervous system|0/16|
|plasma cell|0/15|
|prostate|0/1|
|skin|0/24|
|soft tissue|0/9|
|thyroid|0/2|
|upper aerodigestive|0/22|
|urinary tract|0/29|
|uterus|0/5|
</modal>

== Essentiality in NALM6  ==
    * **<color #00a2e8>Essentiality Rank</color>**: 11274
    * **<color #00a2e8>Expression level (log2 read counts)</color>**: 3.28 
<button type='primary' size='small' modal='Dist_expr'>Expression Distribution</button>
<modal id='Dist_expr' size='lg' title='VDR Expression in NALM6 Cells: 3.28'>
{{:chemogenomics:nalm6 dist.png?nolink |}}
</modal>